표제지
목 차
약어 8
Ⅰ. 서론 9
Ⅱ. 실험 11
1. 시약 및 기구 11
2. Macrocyclic legand(DTD, TTD)의 합성 13
3. 메리필드 펩타이드 이온교환수지(DTDM, TTTM)의 합성 15
4. 수지의 이온교환용량과 분포계수의 측정 18
Ⅲ. 결과 및 고찰 20
1. DTD와 TTD의 특징 20
2. 메리필드 수지를 이용한 DTDM과 TTTM의 특징 20
3. 이온교환용량과 분포계수의 결정 25
4. 컬럼크로마토그래피에 의해 리튬동위원소의 분리 30
1) 이론단수 30
2) 크로마토그래피 계에서 일반적인 양상 33
3) DTDM 과 TTTM 이온 교환수지의 분리 인자 37
Ⅳ. 결론 42
참고문헌 44
ABSTRACT 47
감사의 글 49
Fig. 1 Structure of DTD and TTD 14
Fig. 2 IR spectra of 3,14-dimethyl-2,6,13,17-tetraazatricyclo[4,10,4,01.18,07.12] docosane bonded Merrifield peptide resin(DTDM) 21
Fig. 3 TGA thermogram of 3,14-dimethyl-2,6,13,17-tetraazatricyclo [4,10,4,01.18,07.12]docosane bonded Merrifield peptide resin(DTDM) 22
Fig. 4 IR spectra of 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclotetradecane bonded Merrifield peptide resin(TTTM) 23
Fig. 5 TGA thermogram of 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclotetra decane bonded Merrifield peptide resin(TTTM) 24
Fig. 6 Plot of log distribution coefficient in various conc. of NH4Cl for lithium with 3,14-dimethyl-2,6,13,17-tetraazatricyclo[4,10,4,01.18,07.12]docosane bonded Merrifield peptide resin(DTDM) 27
Fig. 7 Plot of log distribution coefficient in various conc. of NH4Cl for lithium with 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclotetradecane bonded Merrifield peptide resin(TTTM) 28
Fig. 8 Distribution coefficient in various conc. of NH4Cl for lithium with 3,14-dimethyl-2,6,13,17-tetraazatricyclo[4,10,4,01.18,07.12]docosane bonded Me -rrifield peptide resin(DTDM) and 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclo -tetradecane bonded Me 29
Fig. 9 Elution curve for lithium isotope separation with 3,14-dimethyl-2,6, 13,17-tetraazatricyclo[4,10,4,01.18,07.12]docosane bonded Merrifield peptide resin(DTDM) in 2.0 M NH4Cl 31
Fig. 10 Elution curve for lithium isotope separation with 1,4,8,11-tetrameth yl-2,5,9,12-tetraazacyclotetradecane bonded Merrifield peptide resin(TTTM) in 2.0 M NH4Cl 32
Fig. 11 Schematic figure of the elution curve of an element with two isotope 34
Fig. 12 The graphic determination of ε with the results of a chromatographic elution. (a) the isotope ratio of different fractions of the 36
Fig. 13 The graphic determination of ε with the results of a chromatogra -phic elution for lithium ion with 3,14-dimethyl-2,6,13,17-tetraazatricyclo [4,10,4,01.18,07.12]docosane bonded Merrifield peptide resin(DTDM) 40
Fig. 14 The graphic determination of ε with the results of a chromatogra -phic elution for lithium ion with 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclo tetradecane bonded Merrifield peptide resin(TTTM) 41
Table 1. Capacity of 3,14-dimethyl-2,6,13,17-tetraazatricyclo[4,10,4,01.18,07.12] docosane bonded Merrifield peptide resin(DTDM)and 1,4,8,11-tetramethyl -2,5,9,12-tetraazacyclotetradecane bonded Merrifield peptide resin(TTTM) 25
Table 2. Distribution coefficient in various conc. of NH4Cl for lithium with 3,14-dimethyl-2,6,13,17-tetraazatricyclo[4,10,4,01.18,07.12]docosane bonded Me -rrifield peptide resin(DTDM) 25
Table 3. Distribution coefficient in various conc. of NH4Cl for lithium with 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclotetradecane bonded Merrifield peptide resin(TTTM) 26
Table 4. The local enrichment factor for lithium isotopes in each fraction of 3,14-dimethyl-2,6,13,17-tetraazatricyclo[4,10,4,01.18,07.12]docosane bonded Merrifield peptide resin(DTDM) 38
Table 5. The local enrichment factor for lithium isotopes in each fraction of 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclotetradecane bonded Merrifield peptide resin(TTTM) 38
Table 6. Lithium isotope separation factor for ion exchangers 39
Table 7. Distribution coefficient(Kd) versus separation factor(α) of lithium for ion exchangers in 2.0M NH4Cl 39
Scheme 1. Synthetic routes of 3,14-dimethyl-2,6,13,17-tetraazatricyclo [4,10,4,01.18,07.12]docosane(DTD) 13
Scheme 2. Synthetic routes of 3,14-dimethyl-2,6,13,17-tetraazatricyclo [4,10,4,01.18,07.12]docosane bonded Merrifield peptide resin(DTDM) 16
Scheme 3. Synthetic routes of 1,4,8,11-tetramethyl-2,5,9,12-tetraazacyclo tetradecane bonded Merrifield peptide resin(TTTM) 17