Transdifferentiation is a process of conversion of one type of completely differentiated cell to another type. Transdifferentiation of myogenic cells to adipocytes is among the best examples, and is of a special interest among animal biotechnologists. Myoblast to adipocyte conversion finds its direct application in increasing the intramuscular fat, thus engineering the meat marbling. So in this study we have tested the potentials of different transcription factors (PPAR gamma, C/EBP alpha, SREBP1c) natural (serum lipids, LCFA, SCFA) and synthetic compounds (TZDs), hormones (Progesterone, testosterone and estradiol) to induce transdifferentiation under in vitro conditions.