본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

목차보기

표제지

목차

Abstract 8

I. 서론 10

1. 연구의 필요성 10

2. 연구목적 15

3. 연구 가설 15

4. 연구 제한점 17

5. 용어 17

II. 이론적 배경 19

1. FTO 유전자 19

1) FTO 유전자 다형 19

2) FTO 유전자 다형에 따른 비만과 인슐린 21

2. 운동과 대사 22

1) 신체조성 22

2) 운동과 혈중지질 24

3. 비만과 사이토카인(cytokine) 27

1) IL-6(Interleukin-6) 28

2) TNF-α(Tumour necrosis factor-α) 30

4. 대사성 호르몬 32

1) Insulin 32

2) IGF-1(Insulin like growth factor-1) 34

III. 연구 방법 36

1. 연구 대상 36

2. 실험 설계 36

3. 실험 방법 및 절차 37

4. 채혈 및 측정방법 41

1) 채혈 41

2) FTO rs9939609 genotype 41

3) Primer 제작 및 PCR 증폭 42

4) 염기서열 분석을 통한 유전자형 분석 44

5) FTO 유전자다형 결과 45

6) 신체성분 측정방법 46

7) 혈중지질 46

8) IL-6, TNF-α 46

9) Insulin 47

10) IGF-1 47

5. 실험도구 47

6. 자료처리 48

IV. 연구결과 49

1. FTO 유전자 다형에 따른 신체조성의 변화 49

2. FTO 유전자 다형에 따른 혈중지질의 변화 51

3. FTO유전자 다형에 따른 Cytokine의 변화 53

4. FTO유전자 다형에 따른 대사성 호르몬의 변화 56

V. 논의 58

1. 신체조성(Body composition) 58

2. 혈중지질(Blood Lipids) 63

3. 사이토카인(cytokine) 68

1) IL-6(Interluekin-6) 68

2) TNF-α (Tumour necrosis factor-α) 70

4. 대사성 호르몬(Metabolic hormone) 73

1) Insulin 73

2) IGF-1 (Insulin-like growth factor-1) 76

VI. 결론 80

참고문헌 82

List of Tables

Table 1. Physical characteristics of subject 36

Table 2-1. Dance Sport Program process (I) 39

Table 2-2. Dance Sport Program process (II) 40

Table 3. Primer sequence information and fragment size for genotyping analysis of FTO gene mutation 43

Table 4. The FTOgenotype and allele frequency in the subjects 45

Table 5. Experimental equipments 47

Table 6. Change of body composition according to treatment duration exercise 51

Table 7. Change of Blood lipids according to treatment duration exercise 53

Table 8. Change of Cytokine according to treatment duration exercise 55

Table 9. Change of metabolism hormone according to treatment duration exercise 56

List of Figures

Fig. 1. FTO rs9939609 polymorphisme in homo sapiens. 19

Fig. 2. Experimental design. 38

Fig. 3. FTO rs9939609 polymorphism(TT type) 43

Fig. 4. FTO rs9939609 polymorphism(AT type) 43

Fig. 5. Agarose gel electrophoresis of PCR products for FTO gene Lane 1 represents 100 bp ladder molecular size marker. 44

Fig. 6. Change of BW in subject group 60

Fig. 7. Change of FBM in subject group. 61

Fig. 8. Change of %fat in subjet group. 61

Fig. 9. Change of BMI in subject group. 62

Fig. 10. Change of HDL-C in subject group. 64

Fig. 11. Change of LDL-C in subject group. 65

Fig. 12. Change of TG in subject group. 67

Fig. 13. Change of IL-6 in subject group. 69

Fig. 14. Change of TNF-α in subject group. 72

Fig. 15. Change of Insulin hormone in subject group. 75

Fig. 16. Change of IGF-1 in subject group. 78

초록보기

Selecting male students who have obesity over BMI 27 at W University located in Jeollabuk-do was done first to complete this experiment. According to the obesity genotype of this study, independence sampling was done, which were 10 students of AA+AT gene group and 16 students of TT gene group.

Dance sports program as an exercise treatment was done 4 times a week for 12 weeks.

For the first 6 weeks it was performed by 44~55% HRmax, and for the last 6 weeks it was done by 55~66%HRmax.

After every treatment was done, when the students rested, the following result was gained by analyzing change of their body composition (weight, the quantity of body fat, the rate of body fat, BMI), blood lipid (TG, HLD-C, LDL-C), Cytokine (IL-6, TNF-α), and metabolic hormone (insulin, IGF-1).

1. At the change of body composition, the rate of body fat and BMI decreased in TT gene group and AA+AT gene group as the period of exercise treatment became longer. (p<.05)

2. At the change of blood lipid, HDL-C of TT gene group increased more than that of AA+AT gene group as the period of exercise treatment became longer and longer. On the other hand, LDL-C showed a tendency of a decrease in the statistics. (p<.01)

3. At the change of cytokine, IL-6 to inereased But TNF-α of TT gene group decreased more than that of AA+AT gene group statistically as the period of exercise treatment became longer. (p<.01)

4. At the change of metabolic hormone, IGF-1 factor of TT gene group increased more than that of AA+AT gene group as the period of exercise treatment became longer. (p<.01)

To sum up the above result, factors, such as body composition, blood lipid, cytokine, and metabolic hormone of AA+AT group, the obesity gene group, are genetically affected more easily than those of TT group, the normal group.

Therefore, when the exercise treatment is done for obesity, the modification based on FTO genotype should be considered and more extensive study will be needed to get more exact result.

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차