표제지
목차
1. 서론 7
2. 재료 및 방법 9
2.1. 실험재료 9
2.2. DNA 추출 9
2.3. 핵과 사립체 현미부수체 불안정성 분석 9
2.4. 실시간 PCR을 이용한 사립체 복제수 분석 10
2.5. 통계학적 분석 11
3. 성적 14
3.1. 임상병리학적 특성 14
3.2. 핵 현미부수체 불안정성(nuclear microsatellite instability, nMSI) 14
3.3. 사립체 현미부수체 불안정성(mitochondrial microsatellite instability, mtMSI) 14
3.4. 사립체 DNA 복제수(mitochondrial DNA copy number, mtCN) 15
3.5. nMSI, mtMSI 및 mtCN의 상관관계 15
4. 고찰 22
5. 요약 25
참고문헌 26
Abstract 33
초록 35
저자 약력 37
논문 및 저서 37
Table 1. Clinicopathological Characteristics 12
Table 2. List of Primers 13
Table 3. Nuclear MSI Status in Lung Tumors 16
Table 4. Mitochondrial MSI Status in Lung Tumors 17
Table 5. Mitochondrial DNA Copy Number Status in Lung Tumors 18
Table 6. Relationship between mtMSI and nMSI, and between mtMSI and mtCN in Lung Tumors 19
Figure 1. Representative examples of nuclear microsatellite instability at BAT26. Denatured PCR products with formamide loading buffer were electrophoresed through 7.5% polyacrylamide gel... 20
Figure 2. Representative examples of mitochondrial microsatellite instability at the (C)n of the D-loop. Denatured PCR products with formamide loading buffer were electrophoresed through 7.5%... 21