In order to survive in the Fourth Industrial Revolution era and further to lead the future society, the emphasis is placed on the education to develop students' key competencies, as an alternative to traditional lecture style classes. In the study, 176 students in a Foreign Language High school took part in chemisty flipped classroom and were asked to examine and review their study activities and reflect on their attitudes for one year. The analysis focused on the practical significance in their responses revealed that the chemistry class with the reverse method had a positive effect on the students' cognitive and affective domain. This style of lessons enables students to learn effectively and efficiently, such as by being able to easily understand difficult subjects and having long lasting memories, and has effectively enhanced academic performance through individual and peer learning. Most of all, it improved students' self-directed learning abilities and enabled students' meta learning. Students have developed a positive attitude toward chemistry as they actively participated and interested in the classes. They also found that it had a positive influence on friendship formation and personality. These courses are consistent with the direction of education that the new era seeks, and they can be effective professorial-learning approaches to subjects students feel difficult and less interesting.