In this study, we evaluated anti-oxidation and whitening effects of Ligularia stenocephala extract for use as the cosmeceuticals. L. stenocephala was extracted by three different solvents which was n-Hexane, ethyl acetate, H₂O. The free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity of extract of L. stenocephala was in the order: ethyl acetate fraction of leaf (IC50 value of 10.512㎍/mL) > ethyl acetate fraction of stem (IC50 value of 0.230mg/mL) > ethyl acetate fraction of order: ethyl acetate fraction of leaf (IC50 value of 0.230mg/mL) > ethyl acetate fraction of stem (IC50 value of 0.528mg/mL) > H₂O fracton of leaf (IC50 value of 0.799mg/mL). Tyrosinase ingibition activity of L. stenocephala extracts was reduced 29.477% on ethyl acetate fraction of leaf, 13.583% on ethyl acetate fraction of stems. Therefore, L. stenocephala extracts may be sueful as a enw antioxidant and whitening agent to inhibit melanogenesis.