목적: 국내의 나이관련황반변성에 대한 발병률과 임상양상을 알아보고자 하였다.
대상과 방법: 2005년 8월 20일부터 2006년 8월 20일까지 1년간 전국 망막학회 회원을 대상으로 web-base 환자등록을 시행하였다.
나이관련황반변성으로 진단된 50세 이상의 남녀를 대상으로 안저사진, 형광안저혈관조영사진, 과거력, 생활습관, 병력, 안과검사 소견
을 등록하도록 하였다.
결과: 1,141명의 새로 진단된 나이관련황반변성 환자가 등록되었다. 남자가 690명(60.5%), 여자가 451명(39.5%)이었다. 평균연령은
69.7±8.0세였다. 초기 황반변성이 190명, 후기는 951명에서 관찰되었다. 맥락막혈관신생은 전형적이 18.6%, 잠복형이 63.4%였다. 중
심오목 밑 신생혈관이 전체의 80.4%를 차지하였다. 인도시아닌그린혈관조영술을 시행한 580안을 분석한 결과 결절맥락막혈관병증은
184안(31.7%), 망막혈관종성증식은 36안(6.2%)에서 관찰되었다. 나이, 남성, 흡연, 당뇨, 고혈압이 나이관련황반변성의 위험을 증가시
키는 인자로 발견되었다.
결론: 일관적인 등록이 힘들어 정확한 전국의 발병률은 산출하기는 힘들었으나 부산지역 1년 발병률은 최소 0.4%로 추정된다. 서양과
는 달리 삼출성 나이관련황반변성의 31.7%가 결절맥락막혈관병증, 6.2%가 망막혈관종성증식으로 관찰되어 삼출성 나이관련황반변성
의 진단과 치료방침 결정에 유의해야 할 것으로 생각된다.Purpose: To evaluate the incidence and clinical features of age-related macular degeneration (AMD) in Korea
Methods: Web-based (www.armd-nova.or.kr) registration was conducted for AMD patients aged 50 or more who were newly
diagnosed by retinal specialists in Korea from August 20, 2005 to August 20, 2006. Patient data including ophthalmologic examination,
fundus photography, fluorescein angiogram and/or indocyanin green angiogram (ICG), past medical history, behavioral habit,
combined systemic diseases were up-loaded.
Results: Among finally enrolled 1,141 newly diagnosed AMD patients, 690 patients (60.5%) were male and 451 patients (39.5%)
were female. The average age of AMD patients was 69.7?.0. Early AMD was observed in 190 patients and 951 patients had
late AMD. Classic choroidal neovascular membrane (CNVM) was observed in 18.6% of exudative AMD patients and 63.4 % had
occult CNVM. Subfoveal CNVM was observed in 80.4% of the patients with CNVM. Among the 580 exudative AMD eyes that
performed indocyanin green angiography (ICG), 184 eyes (31.7%) had polypoidal choroidal vasculopathy (PCV) and 36 eyes (6.2%)
showed retinal angiomatous proliferation (RAP). Age, male gender, smoking, diabetes and hypertension significantly increased
the risk of the AMD among Koreans.
Conclusions: Because of the low rate of participation by retinal specialists, definite incidence of AMD was not obtainable.
However, the estimated 1-year AMD incidence in the Pusan area of Korea is at least 0.4%. In contrast to Western people, 31.7%
of exudative AMD cases were revealed to be PCV and 6.2% were revealed to be RAP. This discrepancy between ethnic groups
should be considered in the diagnosis and treatment modality selection of Korean AMD patients.