This study was performed to evaluate the efficacy of 0.8% sodium hyaluronic acid solution and crosslinked
hyaluronic acid mixture for the prevention of postoperative intraperitoneal adhesion in rats. Forty-five animals were
divided into three groups ; 0.9% saline treated control group, 1% sodium carboxymethyl cellulose treated group (SCMC),
and 0.8% sodium hyaluronic acid solution and crosslinked hyaluronic acid mixture treated group (SHCH). Adhesions
were induced by suturing both the ileal serosa and peritoneum abrased until petechial bleeding occurred. Fourteen
days later, adhesions were evaluated clinically and histopathologically. The mean tensile strength was significantly
lowest tensile strength. The distance of adhesion site was highest in the control group and significantly decreased in
it was concluded that the SHCH may be useful to prevent postoperative intraperitoneal adhesion in rats.