The purpose of this study was to investigate whether or not the PC-1 K121Q gene variants modulated the degree to which participation in a 12 weeks of a dance sports program improved obesity and its related metabolic syndrome in abdominally obese, middle-aged women. A total of 57 subjects (K121K genotype, n = 37; K121Q + Q121Q genotype,
n = 20) voluntarily participated in 12 weeks of supervised dance sports program (60~70% HRmax), Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR-RFLP) assay was used in this study. Two-way RMANOVA analyses showed that regardless of the PC-1 genotype, participation in the 12-wk dance sports program
significantly improved most of body fatness indices along with TC and blood glucose. In addition, there were significant time ?genotype interactions in changed scores in body weight and HDL-C level such that those with K allele carriers had greater improvements in body weight and HDL-C than those with Q allele carriers. In conclusion,
the current findings suggest that the PC-1 K121Q gene variants can modulate responses of obesity and its related metabolic markers to an aerobic exercise training