This study investigated obese women's general environment, mental depression changes by thermo foot-reflexology (50 minutes/one time and three times/week during 6 weeks) through a questionnaire survey of 33 obese women possessing over 23 body mass index (BMI) in Iksan, they divided into two groups and checked their triglyceride (TG), immunoglobulin G (IgG) and stress changes of blood by thermo foot-reflexology (TFR). As the results, depression changes of experimental group presented meaningful decline of about 7 value after TFR. Cortisol concentration of blood and stress index showed a decline in experimental group. TG and IgG concentration of experimental group showed meaning decrease by TFR. Therefore, we suggest that TFR did decline obese women's mental depression, stress and TG concentration without fall of immune system.