Categorizing Sylvia Nasar’s A Beautiful Mind and Elyn R. Saks’ The Center Cannot Hold: My Journey Through Madness respectively as a neuro-biography and a neuro-memoir, this study explores how these two works deal with the issue of schizophrenia in different narratives and literary genres. A Beautiful Mind delves into the social hysteria of the 1950s America and Dr. John Nash’s unique personality including his genius as the backdrop for the pathogenesis of his schizophrenia. When dealing with Nash’s genius, the author uses nonverbal images instead of realistic narrative style. Like his innate genius, Nash’s schizophrenia remains unrepresentative in the verbal realm and thus exposing the limit of representationism. Saks’ memoir, The Center Cannot Hold: My Journey Through Madness triggers immediacy and “feeling of body” through its subjective and sensational description of the symptoms of schizophrenia. Nonetheless, this memoir does not fully satisfy the reader’s expectation to know everything. Paradoxically, however, it is these limits of representation that allow the readers room to imagine and thus make these books into beautiful literary pieces.