This research aims to examine how research on oyster mushroom cultivation has evolved in South Korea. Since the 1950s, national interest in mushrooms rose sharply, but oyster mushrooms did not attract enough attention. Some researchers jumped into scientific research one after another to achieve artificial cultivation of oyster mushrooms. Although they presented knowledge of the cultivation based on the advanced technology introduced from Japan, it did not resonate in the country. On the other hand, only KIM Sam Soon, who joined late in the late 1960s, produced research on oyster mushrooms that had a social ripple effect enough to arouse the government's interest. The Rural Development Administration was motivated by her scientific achievement and began practical research to distribute the mushrooms in earnest. By the mid-1970s, they rapidly emerged as one of the top three edible mushrooms in South Korea. Then why did her belated scientific research serve as an opportunity to spread the cultivation of oyster mushrooms despite the cases of visible results in their cultivation ahead of KIM? This study will focus on KIM Sam Soon’s scientific research and its ripple, which have become a breakthrough in oyster mushroom cultivation in South Korea.