The shift in the medical paradigm from treatment to prevention and diagnosis has underscored the growing significance ofbiosensors. Notably, the recent COVID-19 pandemic has spurred the widespread adoption of biosensors for the detection ofviral genes and antigens. Consequently, there has been a substantial increase in both the demand for biosensors and the industriesassociated with their production. Furthermore, biosensors find applications not only in healthcare but also in diverse fieldssuch as environmental monitoring, food quality control, military defense, and industrial processes. In this brief review, we delveinto the essential attributes of biosensors, namely sensitivity, selectivity, and stability. We provide an overview of the latestresearch trends aimed at improving these attributes. Additionally, we introduce recent research cases in which these attributesare being applied both in vivo and in vitro.