Title Page
Foreword
Contents
1. Risk Analysis on Chemical Hazards in Agricultural and Animal-originated Foods 4
1-1. Risk Analysis Process 5
1-2. Interaction between Risk Assessment and Risk Management 6
1-3. Problem Formulation 6
1-4. Risk Profile 6
1-5. Procedures of Risk Assessment on Agricultural, Livestock and Fisheries Products 8
2. Risk Assessment for Chemical Hazards in Agricultural and Animal-originated Foods 10
2-1. Hazard Identification 11
1) Considerations for Assessment Data 11
2) Assessment on Substance Characteristics 13
3) (Chemical) Structure - Activity Relationship (SAR) Assessment 13
4) Toxicokinetic and Pharmacokinetic Assessment 14
5) Toxicological Endpoint Assessment 15
6) Bio-dynamics Data Assessment 18
2-2. Hazard Characterization 19
1) Toxicological Threshold Approach 20
2) Non-threshold Effect Evaluation 27
3) Threshold of Toxicological Concern (TTC) Assessment 28
2-3. Exposure Assessment 31
1) Setting Exposure Scenario 31
2) Data for Exposure Assessment 32
3) Basic Data for Exposure Assessment 33
2-4. Risk Characterization 46
1) MOE Assessment 46
2) MOS Assessment 46
3) Cancer Risk (CR) Assessment 47
4) Setting Maximum Residue Limit (MRL) 48
5) Recommendation of Management Options Other than MRL and Reviewing Information Limit 49
3. Risk Assessment for Pesticides in Agricultural and Animal-originated Foods 50
3-1. Definition of Pesticide 50
3-2. Overview of Pesticide Risk Assessment 51
1) Risk Assessment of Long-term Hazard 52
2) Risk Assessment for Pesticides of Short-term Hazard 60
3) (제목없음) 60
4) Risk Assessment Using Tiers Approach 68
4. Risk Assessment for Veterinary Drugs in Agricultural and Animal-originated Foods 73
4-1. Definition of Veterinary Drugs 73
4-2. Overview of Risk Assessment for Veterinary Drugs 75
4-3. Veterinary Drug Risk Assessment Stages 77
1) Hazard Identification 78
2) Hazard Characterization 81
3) Exposure Assessment 82
4-4. Risk Characterization 84
5. Risk Assessment for Environmental Contaminants in Agricultural and Animal-originated Foods 90
5-1. Overview of Risk Assessment for Environmental Contaminants 90
5-2. Risk Assessment of Environmental Contaminants in Agricultural and Animal-originated Foods 90
1) Hazard Identification 90
2) Hazard Characterization 91
3) Exposure Assessment 93
4) Maximum Level (ML) Setting for Environmental Contaminants Using Dietary Exposure Assessment 94
5) Method to Select Appropriate Data for Dietary Exposure Assessment 99
6) Risk Characterization 107
6. Attachments 111
Attachment 1. Terms and Definitions 111
Attachment 2. Agricultural Products Risk Assessment Enforcement Guidelines 115
Attachment 3. Livestock Products Risk Assessment Method, Criteria and Procedures 120
Attachment 4. Guidelines on Risk Assessment Target Substance Selection Criteria, Procedures and Method 124
Attachment 5. Regulations on Risk Assessment Method and Procedures 131
7. Bibliography 138