표제지
목차
Abstract 7
I. 서론 8
II. 연구 내용 및 방법 9
1. 연구 목표 9
2. 연구 내용 및 방법 9
가. 연구 내용 9
나. 연구 방법 9
III. 연구 결과 및 고찰 16
1. 평가대상물질 선정 및 자료 조사 16
가. 위해성평가 대상물질 선정 16
나. 국내·외 평가물질의 관리 현황 16
2. DEHP와 BPA의 유해성 확인 17
3. 노출량-반응 평가 23
4. 노출평가 24
가. 생리학적 약동학 모델을 활용한 노출평가 24
나. 환경오염도 자료를 활용한 노출평가 35
5. 위해도 결정 50
IV. 결론 52
참고문헌 53
[부록] 실내먼지중 비스페놀류 및 프탈레이트류의 상세조사 방법 60
〈Table 1〉 Analysis of 24 target compounds in house dust 12
〈Table 2〉 LC-MS/MS conditions for 8 Bisphenols 13
〈Table 3〉 GC-MS/MS conditions for 16 phthalates 13
〈Table 4〉 The estimated DEHP exposures (㎍/㎏/day) by age based on MEHHP... 29
〈Table 5〉 The estimated BPA exposures (ng/㎏/day) by age based on urinary BPA... 34
〈Table 6〉 Frequency of detection and average concentrations of 16 phthalates... 36
〈Table 7〉 Concentrations of several phthalates in house dust survey from... 37
〈Table 8〉 Environmental concentrations of DEHP by exposure routes 38
〈Table 9〉 Probabilistic assessment of DEHP exposures using environmental... 39
〈Table 10〉 Estimation of oral exposures for infant/toddlers and preschoolers... 42
〈Table 11〉 Detection rates and content levels of DEHP in air fresheners 43
〈Table 12〉 Estimation of inhalation and dermal exposures of air fresheners 43
〈Table 13〉 Frequency of detection and average concentrations of 8... 44
〈Table 14〉 Concentrations of several bisphenols in house dust survey from... 45
〈Table 15〉 Environmental levels of BPA by exposure routes 46
〈Table 16〉 Probabilistic assessment of BPA exposures using environmental... 47
〈Table 17〉 Content levels in BPA-containing products and age-specific... 49
〈Table 18〉 Estimation of HQ by exposure assessment methods based on DEHP... 50
〈Table 19〉 Estimation of HQ by exposure assessment methods based on BPA... 51
〈Figure 1〉 Phthalates and Bisphenols extraction of house dust with solvent. 12
〈Figure 2〉 Structures of PBPK models for DEHP and its metabolites. 24
〈Figure 3〉 Comparison of PBPK modeling-based estimates (solid line) and... 25
〈Figure 4〉 MEHHP and MEOHP levels in urine by age 26
〈Figure 5〉 Correlations between external exposures of DEHP (㎍/day) and urinary... 27
〈Figure 6〉 Correlations between external exposures of DEHP (㎍/day) and urinary... 28
〈Figure 7〉 The estimated DEHP exposures (㎍/㎏/day) by age based on MEHHP... 30
〈Figure 8〉 Structure of PBPK model for BPA 31
〈Figure 9〉 Comparison of PBPK modeling-based estimates (solid line) and... 31
〈Figure 10〉 Urinary levels of MEHHP and MEOHP by age 32
〈Figure 11〉 Correlations between external exposures of BPA (㎍/day) and urinary... 33
〈Figure 12〉 The estimated bisphenol A exposures (ng/㎏/day) by age based on... 34
〈Figure 13〉 Concentrations and relative contribution of 16 phathalates in... 35
〈Figure 14〉 Exposure sources of DEHP by age group 40
〈Figure 15〉 Sensitivity analysis of DEHP exposures for children under 6 years old. 40
〈Figure 16〉 Estimated probability distribution of DEHP exposures by age group. 41
〈Figure 17〉 Concentrations of 8 bisphenols in house dust 45
〈Figure 18〉 Exposure sources of DEHP by age group 47
〈Figure 19〉 Estimated probability distribution of BPA exposures by age group 48