1 Introduction2 A Tale of Two Animats: What Does It Take to Have Goals?3 Meaning and Intentionality = Information + Evolution4 Von Neumann Minds: A Toy Model of Meaning in a Natural World5 Origin Gaps and the Eternal Sunshine of the Second-Order Pendulum6 Agent Above, Atom Below: How Agents Causally Emerge from Their Underlying Microphysics7 Bio from Bit8 I Think, Therefore I Think You Think I Am9 World Without World: Observer-Dependent Physics10 The Role of the Observer in Goal-Directed Behavior11 Wandering Towards Physics: Participatory Realism and the Co-Emergence of Lawfulness12 God’s Dice and Einstein’s Solids13 Finding Structure in Science and Mathematics14 From Athena to AI: The Past and Future of Intention in Nature15 No Ghost in the Machine16 The Man in a Tailcoat17 The Tablet of the Metalaw 18 Wandering Towards a Goal: The Key Role of BiomoleculesAppendix: List of WinnersTitles in This Series