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I. 서론 10

1. 연구의 필요성 10

2. 연구의 목적 13

3. 연구의 가설 14

II. 이론적 배경 15

1. 고환 (testes) 15

2. 테스토스테론 (Testosterone) 21

III. 연구방법 26

1. 실험동물 26

2. 실험방법 28

1) 하지현수 28

2) 고환의 위치 변경을 위한 처치 29

3) 시료의 채취 29

4) 자료 분석 31

IV. 연구결과 32

1. 체중 및 고환의 무게 32

2. 고환의 형태학적 분석 35

3. 고환의 조직학적 특성에 대한 정량적 분석 36

4. 골격근의 조직학적 특성 39

1) 집단별 가자미근섬유의 조직학적 특징 39

2) 집단별 근무게의 비교 40

3) 집단별 근섬유면적의 비교 41

4) 집단별 근섬유둘레의 비교 45

V. 논의 49

1. 체중의 변화 49

2. 고환의 무게 및 형태학적 변화 49

3. 골격근의 형태학적 변화 51

VI. 결론 55

참고문헌 57

Abstract 64

표목차

Table 1. Characterstics of subjects 26

Table 2. Expression of fiber types after ATPase staining at different pH 31

Table 3. Testis weight in different groups 33

Table 4. Histological characteristics of seminiferous tubules and Sertoli cells 36

Table 5. Weight of soleus muscle in different groups 40

Table 6. Cross-sectional area of fiber types in different groups 41

Table 7. Circumference of fiber types in different groups (㎛) 45

그림목차

Fig. 1. Sectional view of testis & epididymis, Principle of Human Physiology. Stanfield CL & Germann WJ. 2008 (3rd edition) 16

Fig. 2. Cross section of seminiferous tubule. Principle of Human Physiology. Stanfield CL & Germann WJ. 2008 (3rd edition) 17

Fig. 3. Cross section of Sertoli cell. Principle of Human Physiology. Stanfield CL & German WJ. 2008 (3rd edition) 18

Fig. 4. Histological section of normal Man's Sertoli cell. Principle of Human Physiology. Stanfield CL & Germann WJ. 2008 (3rd... 19

Fig. 5. Flow chart of Hormonal regulation. Principle of Human Physiology. Stanfield CL & Germann WJ. 2008 (3rd edition) 20

Fig. 6. Synthesis of androgen and testosterone in testis. 22

Fig. 7. Mechanism of testosterone through stem cell. 23

Fig. 8. Treatment of animals 26

Fig. 9. Hindlimb unloading model. 28

Fig. 10. Histomorphometrical analysis of testis. 30

Fig. 11. Change of body weight in different groups 33

Fig. 12. Testis weight (right) per 100g in different groups. 34

Fig. 13. Histological change of testis in different groups. 35

Fig. 14. Diameter of seminiferous tubules in different groups (㎛). 37

Fig. 15. Circumference of seminiferous tubules(㎛). 38

Fig. 16. Histochemical characteristics of soleus muscle in different groups 39

Fig. 17. Fiber area of soleus muscle in different groups. 42

Fig. 18. Fiber area of fast twitch fibers in different groups. 43

Fig. 19. Total fiber area of Soleus muscle in different groups. 44

Fig. 20. Circumference of slow twitch fiber of soleus in different groups. 46

Fig. 21. Circumference of fast twitch fiber of soleus in different groups. 47

Fig. 22. Total circumference of fibers in different groups. 48

참고문헌 (49건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 (1991). ATPase 염색법에 의한 근섬유 형태 구분. 한국체육대학 부설 체육과학연구소 논문집, 10(1), 93-103 미소장
2 Effects of microgravity or simulated launch on testicular function in rats. 네이버 미소장
3 Testosterone Treatment Enhances Regional Brain Perfusion in Hypogonadal Men 네이버 미소장
4 Testosterone and the aging male: To treat or not to treat? 네이버 미소장
5 (2008). Chap. 340. D/Ds of the testes and male reproductive system. In: Harrison's Internal Medicine. McGraw-Hill Professional; 17 edition . 미소장
6 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION. 네이버 미소장
7 Chap. 13. Testes. In: Greenspan's Basis & Clinical Endocrinology, (2007). Gardner DG & Shoback D. McGraw-Hill Medical; 8 edition. 미소장
8 Effects of hindlimb suspension and androgen treatment on testosterone receptors in rat skeletal muscles 네이버 미소장
9 Three "myosin adenosine triphosphatase" systems: the nature of their pH lability and sulfhydryl dependence. 네이버 미소장
10 Are the adverse effects of glitazones linked to induced testosterone deficiency? 네이버 미소장
11 Leydig cells: From stem cells to aging 네이버 미소장
12 Androgen and Erythropoiesis: Evidence for an Androgen Receptor in Erythroblasts from Human Bone Marrow Cultures 네이버 미소장
13 Effects of Caudal Elevation on Testicular Function in Rats Separation of Effects on Spermatogenesis and Steroidogenesis 네이버 미소장
14 A new experimental model for cryptorchidism: inguinoscrotal approach 네이버 미소장
15 Low testosterone levels and the risk of anemia in older men and women. 네이버 미소장
16 Human Cortical Areas Underlying the Perception of Optic Flow: Brain Imaging Studies 네이버 미소장
17 Effects of a simulated microgravity model on cell structure and function in rat testis and epididymis 네이버 미소장
18 http://en.wikipedia.org/wiki/Testosterone 미소장
19 Experimental Cryptorchidism Inhibited Growth of the Rat Ventral Prostate 네이버 미소장
20 Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle 네이버 미소장
21 Nandrolone decanoate pre-treatment attenuates unweighting-induced functional changes in rat soleus muscle. 네이버 미소장
22 Bone-Protecting Effect of Safflower Seeds in Ovariectomized Rats 네이버 미소장
23 Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. 네이버 미소장
24 (1998). Human Anatomy & Physiology, Benjamin cummings science, p.1032~1035 미소장
25 A new experimental model for cryptorchidism: inguinoscrotal approach 네이버 미소장
26 Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. 네이버 미소장
27 Spaceflight and Bone Turnover: Correlation with a New Rat Model of Weightlessness 네이버 미소장
28 Hindlimb unloading rodent model: technical aspects. 네이버 미소장
29 The Hindlimb Unloading Rat Model: Literature Overview, Technique Update and Comparison with Space Flight Data 네이버 미소장
30 (2007). Diagnostic Tests. McGraw-Hill Medical; 5 edition 미소장
31 Rat soleus muscle fiber responses to 14 days of spaceflight and hindlimb suspension. 네이버 미소장
32 Spaceflight effects on beta-adrenoceptor and metabolic properties in rat plantaris. 네이버 미소장
33 The mechanical strength of bone in different rat models of experimental osteoporosis 네이버 미소장
34 Diurnal testosterone levels in peripheral plasma of human male subjects. 네이버 미소장
35 Muscle sarcomere lesions and thrombosis after spaceflight and suspension unloading. 네이버 미소장
36 Is skeletal muscle ready for long-term spaceflight and return to gravity? 네이버 미소장
37 Testes size and testosterone levels in a model for weightlessness 네이버 미소장
38 Effects of spaceflight on the spermatogonial population of rat seminiferous epithelium. 네이버 미소장
39 (1987). Anatomy, vasculature, innervation and fluids of the male reproductive tract. In: The physiology of Reproduction, edited by E. Knobil and J. Neil. New York : Raven, Vol. 1, p.753~836 미소장
40 The Parkes Lecture Heat and the testis 네이버 미소장
41 The effect of microgravity on the reproductive function of male-rats. 네이버 미소장
42 A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids 네이버 미소장
43 Experimentally induced cryptorchidism increases apoptosis in rat testis. 네이버 미소장
44 Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. 네이버 미소장
45 The Effect of Microgravity on Testicular Androgen Secretion 네이버 미소장
46 (2008). Principle of Human Physiology. (3rd edition) Benjamin-Cummings p.675-677 미소장
47 Long-term (6-wk) hindlimb suspension inhibits spermatogenesis in adult male rats. 네이버 미소장
48 Ca(2+)-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases. 네이버 미소장
49 Reversal of weightlessness-induced musculoskeletal losses with androgens: quantification by MRI. 네이버 미소장

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