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Title Page
Contents
I. Abstract 9
II. Introduction 11
III. Materials and Method 21
3.1. Cells, viruses and infection 21
3.2. Viral titration 22
3.3. Cell proliferation assays 22
3.4. Wound-healing assays 23
3.5. Cell cycle analysis 23
3.6. Western blotting 24
3.7. PKA asssay 25
3.8. Flow cytometry analysis 27
3.9. Statistical analysis 27
IV. Results 28
4.1. Forskolin treatment increased the titers of three influenza viruses used as vaccine strains, in MDCK cells 28
4.2. Forskolin treatment inhibited the proliferation of MDCK cells 35
4.3. Forskolin treatment delayed the cell cycle leading to accumulation at the G0/G₁phases in MDCK cells(이미지참조) 40
4.4. ERK1/2 plays a role in late events of influenza virus replication in the presence of forskolin 45
4.5. Forskolin treatment increased the expression of influenza virus HA protein, which increased of ERK1/2 activation 47
V. Discussion 51
VI. References 56
Abstract in Korean 69
Figure 1. The structure of influenza virus 12
Figure 2. The characteristic of cell-based influenza vaccines comparing... 13
Figure 3. The life cycle of influenza virus 15
Figure 4. The signaling process induced by influenza virus in host cells 16
Figure 5. The regulation of cell proliferation mediated by cAMP 19
Figure 6. The differential expression of sialic acid on plasma membrane... 20
Figure 7. Effect of adenylyl cyclase activator on influenza virus... 30
Figure 8. The growth curve of influenza virus under the condition of adenylyl... 31
Figure 9. There is no difference between forskolin treatment times on... 32
Figure 10. The difference output of influenza virus depending on cell... 34
Figure 11. The rate of proliferation of MDCK cells in the presence of... 37
Figure 12. The ability of wound healing decreased under condition of... 38
Figure 13. The signal pathway on inhibition of MDCK cell proliferation by... 39
Figure 14. Analysis of cell cycle dynamics in the presence or absence of... 43
Figure 15. The expression of cell cycle regulatory molecules related G1... 44
Figure 16. Activation of ERK1/2 was activated in a late phase of influenza... 46
Figure 17. The expression of hemagglutinin of the influenza virus on cell... 49
Figure 18. Raf-1/ERK1/2 was activated in forskolin-treated cells with... 50
Figure 19. Postulated mechanism of action of forskolin in MDCK cells... 55
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