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Title Page

ABSTRACT

Contents

Chapter 1. Introduction 8

Chapter 2. Assembly-type Wireless Communication Systems 10

2.1. Selective Wireless Communication Systems 10

2.1.1. Bluetooth-low-energy (BLE) and Wi-Fi communication 10

2.1.2. Near-field Communication (NFC) 12

2.2. Experimental Section 13

2.3. Results 19

2.4. Conclusion 24

Chapter 3. Miniaturized Wireless In-ear Pulse Oximeter 25

3.1. Pulse Oximetry 26

3.2. Experimental Section 28

3.3. Results 30

3.4. Conclusion 37

Chapter 4. Implantable Device Design for Medical Application 39

4.1. Iontophoresis and Electrophoresis 40

4.2. Experimental Section 42

4.3. Results 46

4.4. Conclusion 58

Chapter 5. Conclusion 60

Reference 61

List of Figures

Figure 1. Block diagram of the entire assembly-type wireless communication systems and sensor systems. 13

Figure 2. Configuration of assembly-type wireless communication systems and sensor systems. (a) Image of a single device integrated with Wi-Fi... 19

Figure 3. Measured temperature and light intensity data from each wireless communication system cross connected to each sensor system. (a and b)... 23

Figure 4. Block diagram of wireless miniaturized in-ear device integrated with pulse oximeter. 28

Figure 5. Wireless miniaturized in-ear device integrated with pulse oximeter. (a) Photographs of the fabricated wireless pulse oximeter in a flat state. (b)... 32

Figure 6. Experimental measurement results of wireless in-ear pulse oximeter. (a) Power consumption ratio and variation of each component according to... 36

Figure 7. Basic principle behind iontophoretic drug delivery. Adapted from "Trials and tribulations of skin iontophoresis in therapeutics," by Roustit,... 40

Figure 8. Block diagram of wireless implantable electronic device for drug delivery system. 42

Figure 9. Miniaturized wireless implantable electronic device with open switching circuits. (a) Photographs of the entire circuit including NFC... 48

Figure 10. Experimental electrical characteristics and structure of drug delivery system. (a) Exploded 3D view and fabricated images of drug delivery... 53

Figure 11. 3D structure and functional schematic diagram of iontophoretic and electrophoretic drug delivery system. 55

Figure 12. Experiment results and therapeutic effects of fully implanted entire systems. (a) Measurement results of dose change by reverse state and... 57

초록보기

In this work, we present three flexible, miniaturized wireless device designs for wearable and implant applications, including assembly, body attachment, and implant shapes. Between Bluetooth, Wi Fi, and NFC, the wireless communication system provides the most options for each design and device, or is matched with the most effective wireless communication system. Integration with wireless communication technology enables remote control and monitoring of each design, and certain systems offer real time wireless monitoring.

The assembly type device supports all three wireless communication systems, giving the greatest range of applications and selectivity, and the sensor component can be tailored to the user's specifications. In this study, we demonstrate the applicability of two simple form sensors and three wireless communication systems in varied situations by combining them.

The small wearable device incorporates a pulse oximeter and a Bluetooth communication system, and is intended to be bent, folded, and put into the ear canal. By measuring oxygen saturation, heart rate, and temperature information in real time via the BLE communication system, we are able to continuously monitor an individual's health in daily life and, based on this data, identify abnormal signals and indicate the potential of early intervention.

By combining with iontophoretic and electrophoretic drug delivery systems, the small wireless implanted device is intended for cancer treatment. By providing voltage across three electrodes of the drug delivery system and relying on radio power transfer and radio communication control via NFC, the gadget selectively controls drug release. In addition, pharmaceuticals are released through electrophoresis within the drug carrier, and the released drugs produce an electric field through a counter electrode linked to the tumor for iontophoresis to successfully deliver the medication into the tumor. This gadget presents a revolutionary method of drug delivery and a completely controllable wireless system integration and treatment technique.

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