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기사명/저자명
Antidiabetic activity of angelan isolated from Angelica gigas NaKai / Hwan Mook Kim ; Jong Soon Kang ; Song-kyu Park ; Kiho Lee ; Jee Youn Kim ; Yeon Jin Kim ; Jin Tae Hong ; Youngsoo Kim ; Sang-bae Han 인기도
발행사항
Seoul : The Pharmaceutical Society of Korea, 2008.11.30
수록지명
Archives of pharmacal research. vol. 31 no. 11 (Nov. 2008), pp.1489-1496
자료실
[서울관] 정기간행물실(524호)  도서위치안내(서울관)
외부기관 원문
외부기관 원문
제어번호
KINX2009014570
원문

초록보기 더보기

Angelan isolated from Angelica gigas Nakai inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, and B cells. Here, we report that angelan can inhibit autoimmunity in non-obese diabetic (NOD) mice. Although 80% of the NOD mice had developed diabetes by 24 weeks of age, none of the angelan-treated NOD mice developed diabetes. The mean glucose levels were 118 mg/dl in angelan-treated mice and 506 mg/dl in control NOD mice. Histological examination

of the pancreatic islets revealed that most of the islets isolated from angelan-treated mice were less infiltrated with lymphocytes compared with those of control mice. Spleen cells from diabetic NOD mice could adaptively transfer diabetes into NOD.scid mice, but those from angelan-treated NOD mice

did not, suggesting that angelan caused the spleen cells to lose the ability to destroy β cells. However, angelan did not affect cytokine production of spleen cells. These results suggest that angelan has dual immunomodulatory functions, i.e., immunostimulation in tumor-bearing mice and immunosuppression

in autoimmune diabetic mice.

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참고문헌 (29건) : 자료제공( 네이버학술정보 )더보기

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Understanding autoimmune diabetes: insights from mouse models 네이버 미소장
2 Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages. Vol. 1. pp. 237 미소장
3 Experimental evidences and signal transduction pathways involved in the activation of NF-κB/Rel by angelan in murine macrophages 네이버 미소장
4 Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice. 네이버 미소장
5 The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice. 네이버 미소장
6 Controversies on the prevention of insulin-dependent diabetes mellitus by immunomodulation: lessons from NOD mice treated with beta-1,6;1,3-D-glucan and rhIGF-I. 네이버 미소장
7 Controversies on the prevention of insulin-dependent diabetes mellitus by immunomodulation: lessons from NOD mice treated with beta-1,6;1,3-D-glucan and rhIGF-I. 네이버 미소장
8 Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4 네이버 미소장
9 Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoter. 네이버 미소장
10 Advances in Experimental Medicine and Biology 네이버 미소장
11 BB rat lyp mutation and Type 1 diabetes 네이버 미소장
12 Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. 네이버 미소장
13 T-cell education in autoimmune diabetes: teachers and students 네이버 미소장
14 Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice. 네이버 미소장
15 Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. 네이버 미소장
16 B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4 +CD25 + Immunoregulatory T Cells that Control Autoimmune Diabetes 네이버 미소장
17 Treatment with streptococcal preparation (OK-432) suppresses anti-islet autoimmunity and prevents diabetes in BB rats. 네이버 미소장
18 The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. 네이버 미소장
19 Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. 네이버 미소장
20 Streptococcal preparation (OK-432) inhibits development of type I diabetes in NOD mice. 네이버 미소장
21 Cellular and Molecular Pathogenic Mechanisms of Insulin‐Dependent Diabetes Mellitus 네이버 미소장
22 Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells. 네이버 미소장
23 Tumor-infiltrating CD4+ T lymphocytes express APO2 ligand (APO2L)/TRAIL upon specific stimulation with autologous lung carcinoma cells: role of IFN-alpha on APO2L/TRAIL expression and -mediated cytotoxicity. 네이버 미소장
24 Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug. 네이버 미소장
25 Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. 네이버 미소장
26 Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions 네이버 미소장
27 Prodigiosin blocks T cell activation by inhibiting interleukin-2Ralpha expression and delays progression of autoimmune diabetes and collagen-induced arthritis. 네이버 미소장
28 Activation of NF-κB/Rel in angelan-stimulated macrophages 네이버 미소장
29 Differential activation of murine macrophages by angelan and LPS. 네이버 미소장

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