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The intestinal epithelial cell (IEC) layer of the intestinal
tract makes direct contact with a number of microbiota
communities, including bacteria known to have deleterious
health effects. IECs possess innate protective strategies
against pathogenic challenge, which primarily involve the
formation of a physicochemical barrier. Intestinal tract
mucins are principal components of the mucus layer on
epithelial surfaces, and perform a protective function against
microbial damage. However, little is currently known
regarding the interactions between probiotics/pathogens
and epithelial cell mucins. The principal objective of this
study was to determine the effects of Lactobacillus on the
upregulation of MUC2 mucin and the subsequent inhibition
of E. coli O157:H7 attachment to epithelial cells. In the
current study, the attachment of E. coli O157:H7 to HT-29
intestinal epithelial cells was inhibited significantly by
L. acidophilus A4 and its cell extracts. It is also important
to note that the expression of MUC2 mucin was increased
as the result of the addition of L. acidophilus A4 cell
extracts (10.0 mg/ml), which also induced a significant
reduction in the degree to which E. coli O157:H7 attached
to epithelial cells. In addition, the mRNA levels of IL-8,
IL-1β, and TNF-α in HT-29 cells were significantly
induced by treatment with L. acidophilus A4 extracts.
These results indicate that MUC2 mucin and cytokines
are important regulatory factors in the immune systems
of the gut, and that selected lactobacilli may be able to
induce the upregulation of MUC2 mucin and specific
cytokines, thereby inhibiting the attachment of E. coli
O157:H7.
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도서위치안내: 정기간행물실(524호) / 서가번호: 국내17
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