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초록보기

Although the functional ingredient has been evaluated by the Korea Food and Drug Administration (KFDA) based on scientific evidence, the levels of scientific evidence and consistency of the results might vary according to emerging data. Therefore, periodic re-evaluation may be needed for some functional ingredients. In this study, we re-evaluated scientific evidence for the antioxidant activity of coenzyme Q10 as a functional ingredient in health functional food. Literature searches were conducted using the Medline and Cochrane, KISS, and IBIDS databases for the years 1955-2010 with the search term of coenzyme Q10 in combination with antioxidant. The search was limited to human studies published in Korean, English, and Japanese. Using the KFDA’s evidence based evaluation system for scientific evaluation of health claims, 33 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting a relation between coenzyme Q10 and antioxidant activity. Among 33 studies, significant effects for antioxidant activities were reported in 22 studies and their daily intake amount was 60 to 300 mg. Based on this systematic review, we concluded that there was possible evidence to support a relation between coenzyme Q10 intake and antioxidant activities. However, because inconsistent results have recently been reported, future studies should be monitored.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
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건강기능식품의 기능성을 중심으로 한 오메가-3 지방산 함유유지의 혈행개선 효과에 대한 체계적 고찰 정세원, 김지연, 백주은, 김주희, 곽진숙, 권오란 pp.226-238

전라도 일부농촌지역 여성 노인의 혈중 비타민 B_12_ 수준에 따른 신체계측치 및 임상건강지표들의 비교 곽충실, 조지현, 연미영 pp.239-249

일반인과 유방암 환자간의 식행동 및 영양정보에 관한 인식조사 김경옥, 박현진, 전미선, 이은현, 김현숙 pp.250-260

만 40세 생애전환기 건강진단 수검자의 우울기분과 영양 생활습관 및 건강특성과의 관련성 추지은, 이지민, 조한익, 박윤정 pp.261-275

성인 남성근로자의 체중감소행동 변화단계에 따른 식생활 지침 실천 양상 및 건강신념 비교 송수정, 안홍석, 길진모 pp.276-284

한국 노인의 저작능력에 따른 식품 및 음식섭취 특성 : 2007~2010년 국민건강영양조사 자료에 근거하여 박지은, 안희정, 정성욱, 이윤나, 김초일, 장영애 pp.285-295

참고문헌 (49건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Korea Food and Drug Administration. Regulation for evaluation on efficacy of health functional food. Cheongwon: Korea Food and Drug Administration; 2012 [cited 2012 Dec 27]. Available from: http://www.foodnara.go.kr/hfoodi/industry/ 미소장
2 The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. 네이버 미소장
3 Korea Food and Drug Administration. Specific functional food coenzyme Q10. Cheongwon: Korea Food and Drug Administration; 2012 [cited 2012 Dec 27]. Available from: http://www.foodnara.go.kr/hfoodi/industry/ 미소장
4 U.S. Food and Drug Administration. Guidance, compliance, & regulatory information. Silver Spring (MD): U.S. Food and Drug Administration; 2012 [cited 2012 Dec 27]. Available from: http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/default.htm 미소장
5 U.S. Food and Drug Administration. Qualified Health Claim Petition - selenium and a reduced risk of site-specific cancers (FDA-2008-Q-0323). Silver Spring (MD): U.S. Food and Drug Administration; 2009 미소장
6 Joint FAO/WHO Codex Alimentarius Commission; Food and Agriculture Organization of the United Nations; World Health Organization. Guidelines for use of nutrition and health claims (CAC/GL 23-1997, Rev. 1-2004). Rome: Codex Alimentarius Commission; 2004 미소장
7 Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. 네이버 미소장
8 Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial 네이버 미소장
9 Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans 네이버 미소장
10 Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. 네이버 미소장
11 Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role 네이버 미소장
12 Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. 네이버 미소장
13 Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men 네이버 미소장
14 Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study 네이버 미소장
15 Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women. 네이버 미소장
16 Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease 네이버 미소장
17 Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo. 네이버 미소장
18 Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults 네이버 미소장
19 Randomized, Double-blind, Placebo-controlled Trial of Coenzyme Q10 in Patients with End-stage Renal Failure 네이버 미소장
20 Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study. 네이버 미소장
21 Protection by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping. 네이버 미소장
22 Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting 네이버 미소장
23 Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. 네이버 미소장
24 Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. 네이버 미소장
25 The Role of Oral Coenzyme Q10 in Patients Undergoing Coronary Artery Bypass Graft Surgery 네이버 미소장
26 Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur AS. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003; 246(1-2): 75-82 미소장
27 Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial 네이버 미소장
28 The Effect of Coenzyme Q10 Supplementation on Oxidative Stress Index and Antioxidant Capacity in the Elderly 네이버 미소장
29 Prevention of coronary atherosclerosis by the use of combination therapy with antioxidant coenzyme Q10 and statins. 네이버 미소장
30 Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy 네이버 미소장
31 Weber C, Jakobsen TS, Mortensen SA, Paulsen G, Hølmer G. Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol Aspects Med 1994; 15 Suppl: S97-S102 미소장
32 A randomized trial of coenzyme Q10 in mitochondrial disorders 네이버 미소장
33 Effects of coenzyme Q_10_ on arterial stiffness, metabolic parameters, and fatigue in obese subjects : a double-blind randomized controlled study 소장
34 No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. 네이버 미소장
35 Effects of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists. 네이버 미소장
36 Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. 네이버 미소장
37 Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. 네이버 미소장
38 Effect of Oral Coenzyme Q10 Supplementation on the Oxidation Resistance of Human VLDL+LDL Fraction: Absorption and Antioxidative Properties of Oil and Granule-Based Preparations 네이버 미소장
39 Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes 네이버 미소장
40 The Roles of Coenzyme Q10and Vitamin E on the Peroxidation of Human Low Density Lipoprotein Subfractions 네이버 미소장
41 The chemoprotective effect of coenzyme Q on lipids in the paint and lacquer industry workers. 네이버 미소장
42 Oxidative stress and coenzyme Q 10 supplementation in renal transplant recipients 네이버 미소장
43 Effect of coenzyme Q10 as an antioxidant in beta-thalassemia/Hb E patients. 네이버 미소장
44 Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. 네이버 미소장
45 Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. 네이버 미소장
46 Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. 네이버 미소장
47 In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. 네이버 미소장
48 beta2-Integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10. 네이버 미소장
49 Antioxidative effect of dietary coenzyme Q10 in human blood plasma. 네이버 미소장