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기사명/저자명
Supercritical fluid extract from maca alleviates colitis induced by dextran sulfate sodium in mice / Jae Young Cho, Eun Hye Choi, Jung Il Kang, Changsun Choi, Hyang Sook Chun 인기도
발행사항
Seoul : Korean Society of Food Science and Technology, 2013.06.30
수록지명
Food science and biotechnology. vol.22 no.3 (Jun 2013), pp.859-864
자료실
[서울관] 정기간행물실(524호)  도서위치안내(서울관)
외부기관 원문
외부기관 원문
제어번호
KINX2013132064
원문

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The objective of this study was to investigate the possible protective effects of maca (Lepidium meyenii) extract (MLE) by supercritical fluid extraction on dextran sodium sulfate (DSS)-induced colitis. Experimental colitis was induced by giving male BALB/c mice 3% DSS in drinking water, and MLE (30 mg/kg BW), sulfasalazine (100 mg/kg BW) or vehicle were administered orally. DSS challenge caused significant body weight loss, rectal bleeding, diarrhea, shortened colon length, histological changes, and increased myeloperoxidase (MPO) activity in DSS-treated mice. Oral administration of MLE significantly relieved the symptoms of diarrhea and rectal bleeding, and reduced colonic MPO activity (p<0.05). MLE treatment inhibited expression of several colonic proteins related to inflammatory responses, such as interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and S100 calcium-binding protein A8, whose expressions were increased significantly by DSS treatment. These results suggest that MLE can alleviate DSS-induced colitis in mice by modulating colonic inflammatory mediators.

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참고문헌 (25건) : 자료제공( 네이버학술정보 )더보기

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Management consensus of inflammatory bowel disease for the Asia–Pacific region 네이버 미소장
2 Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. 네이버 미소장
3 Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats 네이버 미소장
4 Korean J. Biotech. Bioeng.. Vol. 23. pp. 153 미소장
5 Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. 네이버 미소장
6 Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD 네이버 미소장
7 Lab. Invest.. Vol. 69. pp. 238 미소장
8 Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. 네이버 미소장
9 Role of interleukin-10 in a murine model of dextran sulfate sodium-induced colitis. 네이버 미소장
10 Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. 네이버 미소장
11 Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. 네이버 미소장
12 Review article: biological drugs in Crohn's disease 네이버 미소장
13 Signal transducers and activators of transcription 3 signaling pathway. An Essential Mediator of Inflammatory Bowel Disease and Other Forms of Intestinal Inflammation 네이버 미소장
14 RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis 네이버 미소장
15 The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis 네이버 미소장
16 Insulin-like growth factor-I and the gastrointestinal system: therapeutic indications and safety implications. 네이버 미소장
17 Oxidants and free radicals in inflammatory bowel disease 네이버 미소장
18 Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause? 네이버 미소장
19 Biologic therapy of inflammatory bowel disease 네이버 미소장
20 Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of β-caryophyllene, a sesquiterpene 네이버 미소장
21 Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. 네이버 미소장
22 Maca: An Andean crop with multi-pharmacological functions. Vol. 40. pp. 783 미소장
23 Antioxidant activity of the cruciferous vegetable Maca ( Lepidium meyenii) 네이버 미소장
24 Supplementation of standardized lipid-soluble extract from maca (Lepidium meyenii) increases swimming endurance capacity in rats 네이버 미소장
25 The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β 네이버 미소장
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