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Purpose: To study the concentration of vascular endothelial growth factor (VEGF) in the aqueous humor before and after intracameral injection of bevacizumab in eyes with neovascular glaucoma, and to detect the duration of an anti-VEGF effect of bevacizumab in the anterior chamber.

Methods: In this prospective interventional case series, 1.25 ㎎ of bevacizumab was injected into the anterior chamber of five eyes in five neovascular glaucoma patients. Aqueous humor samples were obtained just before intracameral injection of bevacizumab and two weeks after injection. The concentrations of VEGF in the aqueous humor were measured using ELISA. To investigate corneal endothelial damage after intrecameral bevacizumab injection, specular microscopy was performed before injection and two weeks after injection. Slit lamp photo and iris fluorescent angiography was performed to determine the regression of iris neovascularization.

Results: After injection, substantial regression of neovascularization or fluorescein leakage was seen in all treated eyes. The VEGF concentrations in the aqueous humor in eyes with NVG were 1181.8±1248.3 pg/㎖ before intracameral injection of bevacizumab. Two weeks after injection, the VEGF concentrations decreased to 33.2±12.2 pg/ ㎖ (p=0.04, Wilcoxon signed rank test). There were no significant changes in IOP or corneal endothelial cells.

Conclusions: Intracameral bevacizumab injection can remarkably reduce iris neovascularization in neovascular glaucoma patients. VEGF levels were significantly decreased two weeks after injection and corneal toxicity was not observed during short term follow-up.

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기사명 저자명 페이지 원문 목차
Results of Extensive Surgical Treatment of Seven Consecutive Cases of Postoperative Fungal Endophthalmitis 양연식 pp.159-163

Acute Comitant Esotropia in a Child With a Cerebellar Tumor 이종민, 김신후, 이정일, 김숙영 pp.228-231

Intravitreal Bevacizumab for the Treatment of Neovascular Glaucoma Associated With Central Retinal Artery Occlusion 사공민, 김진선, 장우혁 pp.215-218

Double-Blind, Randomized, Comparative Study of Meditoxin® Versus Botox® in the Treatment of Essential Blepharospasm 윤진숙, 김재찬, 이상열 pp.137-141

Concentration of Vascular Endothelial Growth Factor After Intracameral Bevacizumab Injection in Eyes With Neovascular Glaucoma 임태훈, 배숭환, 조영재, 이준행, 김황기, 손용호 pp.188-192

C-reactive Protein and Lipid Profiles in Korean Patients With Normal Tension Glaucoma 최재완, 성민철, 최진영, 성경림, Michael S. Kook, 조수근 pp.193-197

Reunion of the Rabbit Superior Oblique Tendon After Weakening Procedures 강대욱, 오지혜, 전보영, 권정윤 pp.198-203

Clinico-Radiologic Findings of Entrapped Inferior Oblique Muscle in a Fracture of the Orbital Floor 김수, 김택근, 김승현 pp.224-227

Kimura's Disease Involving the Ipsilateral Face and Extraocular Muscles 이상준, 송주환, 김신동 pp.219-223

Comparison of Photocoagulation With Combined Intravitreal Triamcinolone for Diabetic Macular Edema 이호영, 이승용, 박종석 pp.153-158

A Case of Accidental Macular Injury by Nd:YAG Laserand Subsequent 6 Year Follow-Up 박동호, 김인택 pp.207-209

Unilateral Scleral Fixation of Posterior Chamber Intraocular Lenses in Pediatric Complicated Traumatic Cataracts 현동원, 이태곤, 조성원 pp.148-152

Management of Dermoid Tumor in the Medial Canthal Area 김남주, 정호경, 곽상인 pp.204-206

A Case of Primary Intraocular Lymphoma Treated by Intravitreal Methotrexate 김은아, 김창현, 이지웅, 조영욱 pp.210-214

Scanning Laser Polarimetry and Optical Coherence Tomography for Detection of Retinal Nerve Fiber Layer Defects 오종현, 김용연 pp.169-175

Structural and Functional Relationships in Glaucoma Using Standard Automated Perimetry and the Humphrey Matrix 박승배, 성경림, Michael S. Kook, 남윤표 pp.176-182

Assessment of Functional Vision Score and Vision-Specific Quality of Life in Individuals With Retinitis Pigmentosa 서제현, 이병주, 유형곤 pp.164-168

A Cadaveric Anatomical Study of the Levator Aponeurosis and Whitnall's Ligament 임한웅, 백두진, 이윤정 pp.183-187

Cataract and Refractive Surgery in : a Survey of KSCRS Members From 1995~2006 윤상철, 선경환, 손희진, 정지웅 pp.142-147

Multiple Myeloma Manifesting as a Fluctuating Sixth Nerve Palsy 나정화, 박신혜, 신선영 pp.232-233

참고문헌 (18건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma 네이버 미소장
2 Intracameral Avastin dramatically resolves iris neovascularization and reverses neovascular glaucoma 네이버 미소장
3 Extracellular Modulating Factors and the Control of Intraocular Neovascularization 네이버 미소장
4 Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. 네이버 미소장
5 Growth factors in the aqueous humor and their clinical significance. 네이버 미소장
6 Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. 네이버 미소장
7 Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma 네이버 미소장
8 Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. 네이버 미소장
9 Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. 네이버 미소장
10 Intravitreal Bevacizumab (Avastin) Injection for Neovascular Glaucoma 네이버 미소장
11 Evidence-based recommendations for the diagnosis and treatment of neovascular glaucoma. 네이버 미소장
12 Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration 네이버 미소장
13 Vascular Endothelial Growth Factor Is Sufficient to Produce Iris Neovascularization and Neovascular Glaucoma in a Nonhuman Primate 네이버 미소장
14 Intravitreal Bevacizumab (Avastin ®) in the Treatment of Neovascular Glaucoma 네이버 미소장
15 Intraviteal Bevacizumab (Avastin(R)) Injection for the Treatment of Early-Stage Neovascular Glaucoma 소장
16 Vascular endothelial growth factor. 네이버 미소장
17 Effect of Bevacizumab on Human Corneal Endothelial Cells: A Six-month Follow-up Study 네이버 미소장
18 Safety Profile of Bevacizumab on Cultured Human Corneal Cells 네이버 미소장

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