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One of the main goals of bone tissue engineering is to develop suitable bio-acceptable materials for bone

graft substitutes, especially for filling large defects. In the present study, porous poly(lactic-co-glycolic acid)

(PLGA)-silica scaffolds were successfully fabricated using indirect microstereolithography technology. The scaffolds

were evaluated in vitro by analyzing their microscopic structure, porosity, and stiffness. Following in vitro

osteogenic induction, human adipose-derived stromal cells (ADSCs) were seeded in the scaffolds, and the expression

levels of osteocalcin mRNA and collagen type I protein were detected by RT-PCR and Western blotting, respectively.

We further evaluated the osteoinductive efficacy of the scaffolds in vivo by implanting human ADSC-seeded

scaffolds into athymic mice. The silica particles improved the mechanical strength of PLGA scaffolds, and the

PLGA-silica scaffolds exhibited better osteogenic potential in vitro than conventional PLGA scaffolds. The in vivo

osteogenic events after scaffold implantation were consistent with those observed in vitro. This study demonstrates

the potential of PLGA-silica scaffolds seeded with human ADSCs as a useful tool for bone tissue engineering

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Changes in the Expression Pattern of Stem Cell Markers in Rat Bone Marrow Mononuclear Cells During Primary Culture 김나경, 최병현, 김길환, 박현선, 박소라, 민병현 pp.344-349

Comparative Study between PLGA and Dermal Tissue for Tracheal Regeneration 김진훈, 김호중, 김진국, 공원호, 서수원 pp.309-315

만능세포 유도기술 강계원 pp.263-268

Comparative Characterization of Skeletal Stem Cells from Various Tissues 조휘문, 남승우, 이은아, 손영숙 pp.367-371

Toxicity Evaluation of Rat Muscle-Derived Stem Cells by Galantamine 김이슬, 김경해, 강미란, 강꽃님, 이재혁, 민병현, 김재호, 김문석, 강윤미 pp.362-366

지방유래중간엽줄기세포의 동결 안정성에 관한 연구 김선희, 김종환, 최민정, 정승태, 홍성화, 홍충만, 오일웅, 박기대, 권오석 pp.350-354

Effect of Surface Modification on Biomechanical Properties of Titanium Alloy Ti6Al4V 한석구, 장윤종, 김용식, 이재영, 임영욱 pp.338-343

Initial Response of Osteoblast-Like Cells on Magnesium Ion Implanted Titanium Surface 신형주, 김대곤, 박찬진, 이희수, 정용수, 조리라, 변응선 pp.330-337

Treatment of Spinal Cord Injury with Bone Marrow-Derived, Cultured Autologous Mesenchymal Stem Cells 전상룡, 이정환, 박진훈, 임대열, 김현수, 성인영, 최경효, 전민호, 김광국 pp.316-322

The Effect of Amniotic Membrane Transplantation on Tendon-Healing in a Rabbit Achilles Tendon Model 양재준, 송광섭, 김미경, 장의찬, 이재성, 장승환 pp.323-329

Novel Measurement of Pressure Inside a Compliant Vascular Scaffold of PLCL 이훈, 김수현, 김상훈, 정종훈, 김상헌 pp.298-308

Comparative Evaluation of Differentiation Potentials of Various Stem Cells from Mesenchymal Tissue Origin 조휘문, 손영숙, 이은아, 남승우, 장정호, 이은경 pp.355-361

PDMS 표면형상과 간헐적 정수압이 중간엽 줄기세포의 분화 및 증식에 미치는 영향 신정욱, 정재영, 김동화, 박소희, 신지원, 한정윤, 강윤경 pp.283-290

NF-κB 신호전달과정의 음성적 조절 : 배아줄기세포에서의 조절을 포함하여 이영희, 이충일, 김영은, 황유원, 한재민, 김경아, 황보은, 심상형, 하향화 pp.269-275

Placenta Derived Mesenchymal Stem Cells in Combination with Polycaprolactone-20% Tricalcium Phosphate Scaffolds for the Treatment of Critical-Sized Defects of the Mandible 이의석, 임재석, 장현석, 권종진, 서병무 pp.276-282

Preparation and Evaluation of PLGA-Silica Scaffold with Human Adipose-Derived Stromal Cells for Bone Tissue Engineering 김기주, 오정완, 진광진, 이정호, 강현욱, 김환묵, 이수홍, 이종원, 오덕영, 조동우, 안상태 pp.291-297

참고문헌 (29건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Biomaterial developments for bone tissue engineering 네이버 미소장
2 Porosity of 3D biomaterial scaffolds and osteogenesis 네이버 미소장
3 Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility 네이버 미소장
4 Bioinspired tissue engineering: The great promise of protein delivery technologies 네이버 미소장
5 Cell adhesion and proliferation evaluation of SFF-based biodegradable scaffolds fabricated using a multi-head deposition system. 네이버 미소장
6 Fabrication of a SFF-based three-dimensional scaffold using a precision deposition system in tissue engineering 네이버 미소장
7 Silicosis and fibrogenesis: Fact and artifact 네이버 미소장
8 Lung cancer induction by crystalline silica. 네이버 미소장
9 Amorphous silica: A review of health effects from inhalation exposure with particular reference to cancer 네이버 미소장
10 PLGA/mesoporous silica hybrid structure for controlled drug release 네이버 미소장
11 Novel mesoporous silica-based antibiotic releasing scaffold for bone repair 네이버 미소장
12 The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro. 네이버 미소장
13 In vitro osteogenesis on a highly bioactive glass-ceramic (Biosilicate). 네이버 미소장
14 Bioceramics: From Concept to Clinic 네이버 미소장
15 Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). 네이버 미소장
16 Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3. 네이버 미소장
17 Subcutaneous Adipocytes Can Differentiate into Bone-Forming Cells in Vitro and in Vivo 네이버 미소장
18 Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. 네이버 미소장
19 In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model. 네이버 미소장
20 Effect of Murine Adipose Derived Stem Cell (ADSC) on Bone Induction of Demineralized Bone Matrix(DBM) in a Rat Calvarian Defect Model 소장
21 J. Fricke, T. Tillotson, Aerogels: production, characterization, and applications, Thin Solid Films, 297, 212 (1997). 미소장
22 A Champa Jayasuriya, NA Ebraheim, Evaluation of bone matrix and demineralized bone matrix incorporated PLGA matrices for bone repair, J Mater Sci: Mater Med, 20(8), 1637 (2009). 미소장
23 The evaluation of the possibilities of using PLGA co-polymer and its composites with carbon fibers or hydroxyapatite in the bone tissue regeneration process - in vitro and in vivo examinations. 네이버 미소장
24 Osteogenic differentiation of human adipose tissue-derived stromal cells (hASCs) in a porous three-dimensional scaffold 네이버 미소장
25 Merck Research Laboratories, The Merck Index fourteenth edition. In: O'Neil MJ, Heckelman PE, Koch CB, Roman KJ, Kenny CM, D'Arecca MR, eds. New Jersey: Merck & Co., Inc. 1466 (2006). 미소장
26 The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly( dl-lactide-co-glycolide) films 네이버 미소장
27 S Areva, V Aaritalo, S Tuusa, et al., Sol-Gel-derived $TiO_2$-$SiO_2$ implant coatings for direct tissue attachment. Part II: Evaluation of cell response, J Mater Sci Mater Med, 18(8), 1633 (2007). 미소장
28 Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition 네이버 미소장
29 Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. 네이버 미소장

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