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The bark of Prunus yedoensis is used in antitussive medicines and in oral herbal formulations for inflammatory skin disorders. In the present study, we explored whether P. yedoensis bark extract (PYE) and its solvent partitioned fractions could modulate lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-a and interleukin (IL)-6 in vivo and in vitro. In addition, we examined the effect of PYE extract and its fractions on LPS-induced NF-jB and mitogen-activated protein kinase (MAPK) signaling in mouse peritoneal macrophages. Oral treatment of PYE decreased serum levels of TNF-a and IL-6 in LPS injected mice. PYE inhibited LPS-induced TNF-a and IL-6 in macrophages at the transcriptional level and also suppressed LPS-induced IjBa degradation and MAPK activation in vitro. Among the fractions, the chloroform fraction, which contains genistein, naringenin, sakuranetin, prunetin, and amygdalin, showed inhibitory effects at much lower concentrations than the water and ethyl acetate fractions. Taken together, our results indicate that PYE was able to inhibit LPS-induced expression of TNF-a and IL-6, the latter of which was more prominent. The effects of PYE on inflammatory cytokine synthesis may involve modulation of NF-jB and MAPK activation.

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기사명 저자명 페이지 원문 목차
Anti-Inflammatory Effects of Vitis thunbergii var. taiwaniana on Knee Damage Associated with Arthritis Ching-Fent Tsai, Kun-Teng Wang, Lih-Geeng Chen, Chia-Jung Lee, Sung-Hui Tseng, Ching-Chiung Wang pp.479-486

Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions 박보경, 박양춘, 정인철, 김승형, 최정은, 박선영, 최정준, 진미림 pp.496-504

Evaluation of Antiradical Activity of Different Cocoa and Chocolate Products : Relation with Lipid and Protein Composition Silvia Vertuani, Emanuela Scalambra, Trotta Vittorio, Alessia Bino, Gemma Malisardi, Anna Baldisserotto, Stefano Manfredini pp.512-516

Prunus yedoensis Bark Inhibits Lipopolysaccharide-Induced Inflammatory Cytokine Synthesis by IκBα Degradation and MAPK Activation in Macrophages 윤정문, 임성빈, 노만광, 박성현, Han-Al Kwon, 이주영, 최호영, 함인혜, 김윤범, 이정민, 김대옥, 박계원, 강희 pp.407-413

Inhibition of Human Low-Density Lipoprotein Oxidation In Vitro by Ginger Extracts K.D. Prasanna, P. Gunathilake, H.P. Vasantha Rupasinghe pp.424-431

Crepidiastrum denticulatum Extract Protects the Liver Against Chronic Alcohol-Induced Damage and Fat Accumulation in Rats 유지혜, 강경수, 윤지호, 김미애, 노주원 pp.432-438

Inhibition of Nonenzymatic Protein Glycation by Pomegranate and Other Fruit Juices Pamela Garner Dorsey, Phillip Greenspan pp.447-454

Glyceollin Transport, Metabolism, and Effects on P-Glycoprotein Function in Caco-2 Cells Chukwuemezie Chimezie, Adina C. Ewing, Syeda S. Quadri, Richard B. Cole, Stephen M. Boué, Christopher F. Omari, Melyssa Bratton, Elena Glotser, Elena Skripnikova, Ian Townley, Robert E. Stratford, Jr pp.462-471

Association Between Chilli Food Habits with Iron Status and Insulin Resistance in a Chinese Population Jiang Li, Rui Wang, Cheng Xiao pp.472-478

Probiotic Screening and Safety Evaluation of Lactobacillus Strains from Plants, Artisanal Goat Cheese, Human Stools, and Breast Milk Martin Gotteland, Maria Jose Cires, Claudia Carvallo, Natalia Vega, Maria Antonieta Ramirez, Pamela Morales, Patricia Rivas, Fernanda Astudillo, Paola Navarrete, Céline Dubos, Alvaro Figueroa, Miriam Troncoso, Carolina Ulloa, Maria Luisa Mizgier, Catalina Carrasco-Pozo, Hernan Speisky, Oscar Brunser, Guillermo Figueroa pp.487-495

Antitumor Activity of the Protein and Small Molecule Component Fractions from Agrocybe aegerita Through Enhancement of Cytokine Production Yi Liang, Hong-Hong Liu, Yi-Jie Chen, Hui Sun pp.439-446

Effect of Tomato Industrial Processing(Different Hybrids, Paste, and Pomace) on Inhibition of Platelet Function In Vitro, Ex Vivo, and In Vivo Rosio Rodríguez-Azúa, Adriana Treuer, Rodrigo Moore-Carrasco, Daniel Cortacáns, Margarita Gutiérrez, Luis Astudillo, Eduardo Fuentes, Iván Palomo pp.505-511

Feijoa sellowiana Berg Fruit Juice : Anti-Inflammatory Effect and Activity on Superoxide Anion Generation Maria T. Monforte, Vincenzo Fimiani, Francesco Lanuzza, Clara Naccari, Salvatore Restuccia, Enza M. Galati pp.455-461

Actein Isolated from Black Cohosh Promotes the Function of Osteoblastic MC3T3-E1 Cells 이영순, 최은미 pp.414-423

참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Study of the chemical constituents of Pruni Cortex and its related parts 네이버 미소장
2 Jung HA, Kim AR, Chung HY, Choi JS, In vitro antioxidant activity of some selected Prunus species in Korea. Arch Pharm Res 2002; 25:865–872. 미소장
3 Jo K, Lee SE, Lee SW, Hwang JK, Prunus yedoensis Matsum. stimulates glucose uptake in L6 rat skeletal muscle cells by activating AMP-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways. Nat Prod Res 2012; 26:1610–1615. 미소장
4 Kang GJ, Lee HJ, Yoon WJ, Yang EJ, Park SS, Kang HK, Park MH, Yoo ES, Prunus yedoensis inhibits the inflammatory chemokines, MDC and TARC, by regulating the STAT1-signaling pathway in IFN-g-stimulated HaCaT human keratinocytes. Biomol Ther 2008; 16:394–402. 미소장
5 Semenzato G, Tumour necrosis factor, a cytokine with multiple biological activities. Br J Cancer 1990; 61:354–361. 미소장
6 Gaestel M, Kotlyarov A, Kracht M, Targeting innate immunity protein kinase signalling in inflammation. Nat Rev 2009; 8:480–499. 미소장
7 Shared principles in NF-kappaB signaling. 네이버 미소장
8 Aoki K, Ishida Y, Kikuta N, Kawai H, Kuroiwa M, Sato H, Role of CXC chemokines in the enhancement of LPS-induced neutrophil accumulation in the lung of mice by dexamethasone. Biochem Biophys Res Commun 2002; 294:1101–1108. 미소장
9 Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model 네이버 미소장
10 Bhattacharyya S, Ratajczak CK, Vogt SK, Kelley C, Colonna M, Schreiber RD, Muglia L, TAK1 targeting by glucocorticoids determines JNK and IjB regulation in Toll-like receptor-stimulated macrophages. Blood 2010; 115:1921–1931. 미소장
11 Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis 네이버 미소장
12 Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase. 네이버 미소장
13 MEKK3 is essential for lipopolysaccharide‐induced interleukin‐6 and granulocyte–macrophage colony‐stimulating factor production in macrophages 네이버 미소장
14 Ghezzi P, Sacco S, Agnello D, Marullo A, Caselli G, Bertini R, LPS induces IL-6 in the brain and in serum largely through TNF production. Cytokine 2000; 12:1205–1210. 미소장
15 Verdrengh M, Jonsson IM, Holmdahl R, Tarkowski A, Genistein as an anti-inflammatory agent. Inflamm Res 2003; 52:341–346. 미소장
16 Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages. 네이버 미소장
17 Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor alpha in LPS/IFN-gamma-activated RAW 264.7 macrophages. 네이버 미소장
18 Yang G, Ham I, Choi HY, Anti-inflammatory effect of prunetin via the suppression of NF-kappaB pathway. Food Chem Toxicol 2013; 58C:124–132. 미소장
19 Production of Cytokine and NO by RAW 264.7 Macrophages and PBMC In Vitro Incubation with Flavonoids 소장
20 Toledo AC, Sakoda CP, Perini A, Pinheiro NM, Magalhaes RM, Grecco S, Tiberio IF, Camara NO, Martins MA, Lago JH, Prado CM, Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model. Br J Pharmacol 2013; 168:1736–1749. 미소장
21 In vitro Antiinflammatory Activity of Amygdalin in Murine Marcrophage Raw 264.7 Cells 소장

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