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Insulin detemir is a long-acting basal insulin analogue recently introduced in veterinary medicine for treatment of canine diabetes mellitus. As there are only limited studies in dogs, long-term evaluation of insulin detemir in veterinary medicine is required. In this study, we investigated trends in12-hour blood glucose concentration during hospitalization and evaluated initial and following doses of insulin detemir for several months in six diabetic dogs. The mean levels of blood glucose over 12-hour periods were between 113.5 to 327.2 mg/dL, and the average glucose nadir was 103 mg/dL in the six dogs. The dogs were treated with a mean dosage of 0.24 U/kg of insulin detemir, but hypoglycemia was observed in four of the dogs at the first monthly follow-up. Thus, insulin doses were adjusted according to the nadir levels of glucose observed during the follow-up periods (range, 1 to 16 months). The total range of insulin doses throughout the study period was between 0.1 and 0.4 U/kg. Changes in insulin doses in each dog during the follow-up period were not variable. We suggest that insulin detemir might be not only an alternative choice against traditional insulin for patients with insulin resistance or concurrent disease but also an effective home therapy medication in canine patients with DM. This study could help inform veterinary practitioners regarding the use of insulin detemir for canine insulin-dependent DM.

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참고문헌 (22건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Studies of the metabolic effects of acute insulin deficiency. I. Mechanism of impairment of hepatic fatty acid and protein synthesis. 네이버 미소장
2 Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis 네이버 미소장
3 Nelson RW. Canine diabetes mellitus. In: Feldman EC, Nelson RW, Reusch CE, Catharine J, Scott-Moncrieff R (eds.). Canine & Feline endocrinology. 4th ed. St. Louis (MO): Elsevier Saunders ; 2015. p. 213-257. 미소장
4 The mechanism of glycosuric diuresis in diabetic man. 네이버 미소장
5 Factors contributing to the degree of polyuria in a patient with poorly controlled diabetes mellitus 네이버 미소장
6 Canine diabetes mellitus: can old dogs teach us new tricks? 네이버 미소장
7 Nelson RW. Disorders of the endocrine pancreas. In: Nelson RW, Couto CG (eds.). Small animal internal medicine. 5th ed. St. Louis (MO): Elsevier Saunders ; 2014. p. 777-823. 미소장
8 Nelson RW. Canine diabetes mellitus. In: Ettinger SJ, Feldman EC (eds.). Textbook of veterinary internal medicine. 7th ed. St. Louis (MO): Elsevier Saunders ; 2010. p. 1782-1796. 미소장
9 Rand JS, Fleeman LM, Farrow HA, Appleton DJ, Lederer R. Canine and feline diabetes mellitus: nature or nurture? J Nutr 2004 ; 134:2072S-2080S. 미소장
10 The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin 네이버 미소장
11 Synthetic insulin analogs and their use in dogs and cats. 네이버 미소장
12 Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albumin. 네이버 미소장
13 Behrend EN, Civco TD, Booth DM. Drug therapy for endocrinopathies. In: Booth DM (ed.). Small animal clinical pharmacology & therapeutics. 2nd ed. St. Louis (MO): Elsevier Saunders ; 2012. p. 783-847. 미소장
14 Insulin detemir under steady‐state conditions: no accumulation and constant metabolic effect over time with twice daily administration in subjects with Type 1 diabetes 네이버 미소장
15 Heise T, Pieber TR. Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies. Diabetes Obes Metab 2007 ; 9:648-659. 미소장
16 Time-action profiles of insulin detemir in normal and diabetic dogs. 네이버 미소장
17 Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trial. 네이버 미소장
18 Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in Type 1 diabetes 네이버 미소장
19 Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart. 네이버 미소장
20 Hermansen K, Madsbad S, Perrild H, Kristensen A, Axelsen M. Comparison of the soluble basal insulin analog insulin detemir with NPH insulin: a randomized open crossover trial in type 1 diabetic subjects on basal-bolus therapy. Diabetes Care 2001 ; 24:296-301. 미소장
21 Pieber TR, Draeger E, Kristensen A, Grill V. Comparison of three multiple injection regimens for Type 1 diabetes: morning plus dinner or bedtime administration of insulin detemir vs. morning plus bedtime NPH insulin. Diabet Med 2005 ; 22:850-857. 미소장
22 Inpatient Management of Hyperglycemia and Diabetes 네이버 미소장

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