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Objective Altered serum S100B protein levels have been shown in several psychiatric disorders. Our aim was to investigate whether plasma S100B is different in patients with panic disorder (PD) when compared with controls. Our second aim was to investigate whether treatment with SSRIs have an effect on S100B levels in patients with PD.

Methods The sample included 32 patients diagnosed with PD (21 women, 11 men) per DSM-IV criteria and 21 healthy controls (11 women, 10 men). S100B levels were measured with BioVendor Human S100B ELISA (Enzyme Linked Immunosorbent Assay) kit.

Results 14 patients were not on drug treatment (43.8%) while 18 patients were taking various SSRIs. Median S100B value was 151.7 pg/mL (minimum-maximum: 120.4–164.7 pg/mL) in the control group, 147.4 pg/mL (minimum-maximum: 138.8–154.1 pg/mL) in the drug free group and 153.0 pg/mL (minimum-maximum: 137.9–164.7 pg/mL) in the treatment group. Kruskal-Wallis analysis showed a significant diffrerence among the three groups (z=9.9, df=2, p=0.007). Follow up Mann-Whitney-U tests indicated that while the control and the patients with treatment were not significantly different (z=-0.05, p=0.96), there were significant differences between the control group and untreated patients (z=-2.6, p=0.009) and treated and untreated patients (z=-3.0, p=0.003).

Conclusion Our results suggested that, serum S100B protein level might be decreased in untreated PD patients and that patients who were treated with SSRIs had similar S100B level to healthy controls.

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기사명 저자명 페이지 원문 목차
Vilazodone for the Treatment of Major Depressive Disorder : Focusing on Its Clinical Studies and Mechanism of Action Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A. Patkar, Prakash S. Masand, Chi-Un Pae pp.155-163

Prevalence and Correlates of DSM-IV Mental Disorders in South Korean Adults : The Korean Epidemiologic Catchment Area Study 2011 Maeng Je Cho, Su Jeong Seong, Jee Eun Park, In-Won Chung, Young Moon Lee, Ahn Bae, Joon Ho Ahn, Dong-Woo Lee, Jae Nam Bae, Seong-Jin Cho, Jong-Ik Park, Jungwoo Son, Sung Man Chang, Bong-Jin Hahm, Jun-Young Lee, Jee Hoon Sohn, Jin Sun Kim, Jin Pyo Hong pp.164-170

Childhood Exposure to Psychological Trauma and the Risk of Suicide Attempts : The Modulating Effect of Psychiatric Disorders Subin Park, Jin Pyo Hong, Hong Jin Jeon, Sujeong Seong, Maeng Je Cho pp.171-176

Wake Up Time, Light, and Mood in a Population Sample Age 40–64 Years Takuro Endo, Daniel F. Kripke, Sonia Ancoli-Israel pp.177-182

A Comparison of Personality Characteristics and Psychiatric Symptomatology between Upper Airway Resistance Syndrome and Obstructive Sleep Apnea Syndrome Soo-Jung So, Heon-Jeong Lee, Seung-Gul Kang, Chul-Hyun Cho, Ho-Kyoung Yoon, Leen Kim pp.183-189

The Psychometric Properties of the Korean Version of the Verbal Abuse Questionnaire in University Students Bumseok Jeong, Sang Won Lee, Jong-Sun Lee, Jae Hyun Yoo, Ko Woon Kim, Sooyun Cho, Jee-Young Ahn, Jeewook Choi pp.190-196

The Relationship between Type D Personality and Heart Rate Variability in Community Mental Health Center Users Noeul Kang, Jeung-Suk Lim, Taik-Gun Hwang, Sook-Haeng Joe, Moon-Soo Lee pp.197-203

Celebrity Suicides and Their Differential Influence on Suicides in the General Population : A National Population-Based Study in Korea Woojae Myung, Hong-Hee Won, Maurizio Fava, David Mischoulon, Albert Yeung, Dongsoo Lee, Doh Kwan Kim, Hong Jin Jeon pp.204-211

A 2-Year Psychological Autopsy Study of Completed Suicides in the Athens Greater Area, Greece Antonios Paraschakis, Ioannis Michopoulos, Christos Christodoulou, Filippos Koutsaftis, Lefteris Lykouras, Athanassios Douzenis pp.212-217

Validation of the Mood and Anxiety Symptom Questionnaire in Korean Adolescents Seul-Ah Lee, Keun-Hyang Kim, Sun-Mi Cho pp.218-226

Increased Cognition Connectivity Network in Major Depression Disorder : A fMRI Study Ting Shen, Cao Li, Biao Wang, Wei-min Yang, Chen Zhang, Zhiguo Wu, Mei-hui Qiu, Jun Liu, Yi-feng Xu, Dai-hui Peng pp.227-234

Korean Facial Emotion Recognition Tasks for Schizophrenia Research Yong-Chun Bahk, Seon-Keong Jang, Jee Ye Lee, Kee-Hong Choi pp.235-241

Metabolic Disturbances Independent of Body Mass in Patients with Schizophrenia Taking Atypical Antipsychotics Shi Hyun Kang, Jong Il Lee pp.242-248

Proteomic Analysis of Serum from Patients with Major Depressive Disorder to Compare Their Depressive and Remission Statuses Jiyeong Lee, Eun-Jeong Joo, Hee-Joung Lim, Jong-Moon Park, Kyu Young Lee, Arum Park, AeEun Seok, HooKeun Lee, Hee-Gyoo Kang pp.249-259

Serum S100B Protein Levels in Patients with Panic Disorder : Effect of Treatment with Selective Serotonine Reuptake Inhibitors Berna Cagatay Kaya, Hasan Karadag, Ozgur Oner, Aysegul Kart, Mehmet Hakan Turkcapar pp.260-262

MEIS1, a Promising Candidate Gene, Is Not Associated with the Core Symptoms of Antipsychotic-Induced Restless Legs Syndrome in Korean Schizophrenia Patients Seung-Gul Kang, Heon-Jeong Lee, Seung-Hwan Lee, Leen Kim pp.263-267

The Relationship between Depression, Anxiety, Somatization, Personality and Symptoms of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Jun Sung Koh, Hyo Jung Ko, Sheng-Min Wang, Kang Joon Cho, Joon Chul Kim, Soo-Jung Lee, Chi-Un Pae pp.268-273

Psychiatric Symptoms in Temporal Lobe Epilepsy with Left Mesial Hippocampal Sclerosis Hyun Jang, Sang Hoon Kim, Sang Hag Park, Il Han Choo, Seung Gon Kim pp.274-277

Evidence-Based Treatment for Depressive Disorder Chi-Un Pae pp.278-279

참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Sadock BJ, Sadock VA. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. 미소장
2 Gulec C, Koroglu E. Basic Psychiatry Textbook. Ankara: Physicians Broadcasting Union; 1997. 미소장
3 Michael H. Ebert M, Loosen T, Nurcombe B. Current Diagnosis and Treatment in Psychiatry. New York: McGraw Hill; 2003. 미소장
4 S100B in brain damage and neurodegeneration. 네이버 미소장
5 S100b expression in and effects on microglia 네이버 미소장
6 Stimulation of astroglial 5-HT 1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology 네이버 미소장
7 Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin 네이버 미소장
8 Chronic fluoxetine treatment changes S100B expression during postnatal rat brain development. 네이버 미소장
9 Neurotrophic factor S100 beta in major depression. 네이버 미소장
10 Rothermundt M, Misler U, Arolt V, Peters M, Leadbeater J, Wiesmann M, et al. Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology. Mol Psychiatry 2001;6:445-449. 미소장
11 Serum markers support disease-specific glial pathology in major depression. 네이버 미소장
12 Schroeter ML, Steiner J. Elevated serum levels of the glial marker protein S100B are not specific for schizophrenia or mood disorders. Mol Psychiatry 2009;14:235-237. 미소장
13 S100B protein in neurodegenerative disorders. 네이버 미소장
14 Schroeter ML, Sacher J, Steiner J, Schoenknecht P, Mueller K. Serum S100B represents a new biomarker for mood disorders. Curr Drug Targets 2013;14:1237-1248. 미소장
15 S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: a postmortem study. 네이버 미소장
16 Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus 네이버 미소장
17 Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor. 네이버 미소장
18 The astroglial protein S100B and visually evoked event-related potentials before and after antidepressant treatment 네이버 미소장
19 Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression. 네이버 미소장
20 The Dual Role of Serotonin in Defense and the Mode of Action of Antidepressants on Generalized Anxiety and Panic Disorders 네이버 미소장
21 5-HT and mechanisms of defence. 네이버 미소장

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