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In order to prepare new antiepileptic drugs with a broader clinical application and lower toxic side effects, we have employed esterification and condensation reactions (we call it Niche Chemistry) to reduce the use of valproic acid as the target molecule. In combination with the study of a broad-spectrum of novel anticonvulsants, we have synthesized two valeric acid derivative compounds [(4-acetamidophenyl 2-propylvalerate (1), and (E)-5-(4-((2-propylpentanoyl)oxy)styryl)-1,3-phenylene bis(2-propylvalerate) (2) by an esterification reaction. The maximum shock seizure test for products 1 and 2 has been successfully carried out, and their cytotoxic activity and survival effects have also been carefully investigated.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Efficient synthesis of long-wavelength absorbing cyanochlorophyll a derivatives via stereoselective Horner–Wadsworth–Emmons reaction Huiqiang Wu, Xiangmin Wang, Yang Liu, Yu Zhao, Xinyue Wang, Woo Kyoung Lee, Young Key Shim, Il Yoon, Xinming Xu, Jiazhu Li p. 504-512

Effect of an alkoxyliertes beta naphthol on Cu electrodeposition for application to low-resistivity Cu interconnects Hoyoung Suh, Mina Heo, Ji-Hyun Lee, Jin-Gyu Kim, Kimin Hong p. 530-536

An amide analog of (-)-epigallocatechin gallate shows preferential cytotoxicity toward triple-negative breast cancer cells Tae Gum Lee, Yulim Kim, Woong Jung, Mi Kyoung Kim, Youhoon Chong p. 496-497

Computational study of pyrimidin-2-aminopyrazol-hydroxamate-based JAK2 inhibitors for the treatment of myeloproliferative neoplasms Seketoulie Keretsu, Swapnil Pandurang Bhujbal, Seung Joo Cho p. 542-551

Synthesis, dispersion, and tribological performance of alkyl-functionalized graphene oxide as an oil lubricant additive and synergistic interaction with IF-WS2 Jong-Seok Han, Jin-Yeong Choi, Min Yoo, Chang-Seop Lee p. 518-529

Highly porous polycaprolactone membrane : a biocompatible promotor for oxidative hydroxylation of arylboronic acids Gyu-Tae Kwon, In-Kyun Lim, Ueon Sang Shin, Seung-Hoi Kim p. 574-577

Analysis of blood ethanol pharmacokinetics in hypoxia-exposed rabbit Choong-sik Oh, Dongsup Song, Woonjung Kim, Seungho Lee p. 498-503

Cage effect on oxidation of dimethyl sulfoxide via Pd2L4 prolate spheroids Seo Young Hwang, Dongwon Kim, Haeri Lee, Ok-Sang Jung p. 513-517

Identification of TRD-35 as potent and selective DRAK2 inhibitor Imran Ali, Sangjun Park, Myoung Eun Jung, Nari Lee, Maimoona Bibi, Chong Hak Chae, Kyung-Min Yang, Seong-Jin Kim, Gildon Choi, Kwangho Lee p. 567-569

Stereoselective determination of thyroxine enantiomers on chiral crown ether column by UPLC-ESI-Tandem mass spectrometry Maheshwor Thapa, Suraj Adhikari, Seonghoon Na, Hye-Ran Yoon, Wonjae Lee p. 563-566

Enantioselective organocatalytic Michael addition and ring closure cascade reaction of o-quinone methides with nitriles Jin Wha Park, Subin Jang, Mi Hyeon Choo, Dae Young Kim p. 570-573

Water-soluble polymeric probes for the pH-tunable fluorometric detection of hydrogen peroxide Tiara Nur Annisa, Hyung-il Lee p. 537-541

Graphene quantum dots enhanced photocatalytic activity of Sb2WO6 under ultraviolet- and visible-light irradiation Shan Li, Zhongping Chen, Datong Wu, Yong Qin, Yong Kong p. 552-557

Synthesis and antiepileptic activity evaluation of valproic acid derivatives by Niche chemistry Ju Hyun Song, Song Mi Bae, Whae Ran Bae, Jin Sun Huh, Yu Chen, Il Soo Jeong, Dai Il Jung p. 558-562

참고문헌 (35건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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4 S. J. Nevitt, A. G. Marson, J. Weston, C. Tudur Smith, Cochrane Database Syst. Rev. 2017, 2. 미소장
5 R. S. Fisher, C. Acevedo, A. Arzimanoglou, A. Bogacz, J. H. Cross, C. E. Elger, J. Engel Jr.. , L. Forsgren, J. A. French, M. Glynn, D. C. Hesdorffer, B. I. Lee, G. W. Mathern, S. L. Moshé, E. Perucca, I. E. Scheffer, T. Tomson, M. Watanabe, S. Wiebe, Epilepsia 2014, 55, 475. 미소장
6 B. G. Gunn, T. Z. Baram, Trends Neurosci. 2017, 40, 667. 미소장
7 N. Marchi, M. Banjara, D. Janigro, J. Neurosci. Methods 2017, 260, 118. 미소장
8 Neurotherapeutics: Concept, Translation, Transition 네이버 미소장
9 D. Jazayeri, J. Graham, A. Hitchcock, T. J. O’Brien, F. J. E. Vajda, Seizure 2018, 56, 111. 미소장
10 I. C. George, Neurology 2017, 7, 363. 미소장
11 J. Weston, R. Bromley, C. F. Jackson, N. Adab, J. Clayton-Smith, J. Greenhalgh, J. Hounsome, A. J. McKay, T. S. Catrin, Cochrane Database Syst. Rev. 2016, 11. 미소장
12 Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes. 네이버 미소장
13 H. Y. Kay, D. L. Greene, S. Kang, A. Kosenko, N. Hoshi, J. Clin. Invest. 2015, 125, 3904. 미소장
14 J. P. Routy, C. L. Tremblay, J. B. Angel, B. Trottier, D. Rouleau, J. G. Baril, M. Harris, S. Trottier, J. Singer, N. Chomont, R. P. Sékaly, M. R. Boulassel, HIVMed 2012, 13, 291. 미소장
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16 K. Bibbins-Domingo, Ann. Intern. Med. 2016, 164, 836. 미소장
17 J. S. Berger, A. Lala, M. J. Krantz, G. S. Baker, W. R. Hiatt, Am. Heart J. 2011, 162, 115. 미소장
18 CELL PROLIFERATION 네이버 미소장
19 N.A.Nordin, T. W. Chai, B. L. Tan, C. L. Choi,A.N. A. Halim, H. Hussain, Z. Ngaini, J. Chem. 2017, 10, 1155. 미소장
20 I. Alkabodi, S. Almekhlafi, D.’a. A. Ibrahim, J. Chem. Pharm. Res. 2016, 8, 307. 미소장
21 M. De Martino, A. Chiarugi, Pain Therapy 2015, 4, 149. 미소장
22 A. Janin, J. Monnet, J. Int. Med. Res. 2014, 42, 347. 미소장
23 H. Madden, J. Harris, C. Blickem, R. Harrison, H. Timpson, BMC Health Serv. Res. 2017, 17, 604. 미소장
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25 T. Ahmed, S. Javed, S. Javed, A. Tariq, D. Šamec, S. Tejada, S. F. Nabavi, N. Braidy, S. M. Nabavi, Mol. Neurobiol. 2017, 54, 2622. 미소장
26 M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Geny, M. Laakso, P. Puigserver, J. Auwerx, A. Gerhart-Hines, M. Lerin, D. Messadeq, M. Lambert, E. Geny, L. P. Auwerx, Cell 2006, 127, 1109. 미소장
27 M. Lopez, R. J. Dempsey, R. Vemuganti, Neurochem. Int. 2015, 89, 75. 미소장
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29 S. Sharan, S. Nagar, Drug Metab. Dispos. 2013, 41, 1163. 미소장
30 M. M. Castel-Branco, G. L. Alves, I. V. Figueiredo, A. C. Falc~ao, M. M. Caramona, Methods Find Exp. Clin. Pharmacol. 2013, 31, 101. 미소장
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34 P. Graidist, M. Martla, Y. Sukpondma, Nutrients 2017, 7, 2707. 미소장
35 C. Bosio, G. Tomasoni, R. Martínez, A. F. Olea, H. Carrasco, J. Villena, Chem. Biol. Interact. 2015, 242, 415. 미소장

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