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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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결과 내 검색 동의어 포함

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초록보기

Because of repeated failures of clinical trials, the concept of Alzheimer's disease (AD) has been changing rapidly in recent years. As suggested by the National Institute on Aging and the Alzheimer's Association Research Framework, the diagnosis and classification of AD is now based on biomarkers rather than on symptoms, allowing more accurate identification of proper candidates for clinical trials by pathogenesis and disease stage. Recent development in neuroimaging has provided a way to reveal the complex dynamics of amyloid and tau in the brain in vivo, and studies of blood biomarkers are taking another leap forward in diagnosis and treatment of AD. In the field of basic and translational research, the development of animal models and a deeper understanding of the role of neuroinflammation are taking a step closer to clarifying the pathogenesis of AD. Development of big data and the Internet of Things is also incorporating dementia care and research into other aspects. Large-scale genetic research has identified genetic abnormalities that can provide a foundation for precision medicine along with the aforementioned digital technologies. Through the first international conference of the Korean Dementia Association, experts from all over the world gathered to exchange opinions with association members on these topics. The Academic Committee of the Korean Dementia Association briefly summarizes the contents of the lectures to convey the depth of the conference and discussions. This will be an important milestone in understanding the latest trends in AD's pathogenesis, diagnostic and therapeutic research and in establishing a future direction.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Executive summary of the 2019 international conference of Korean dementia association : exploring the novel concept of Alzheimer's disease and other dementia : a report from the Academic Committee of the Korean Dementia Association Kee Hyung Park, Jae-Sung Lim, Sang Won Seo, Yong Jeong, Young Noh, Seong-Ho Koh, Jae-sung Bae, Sun Ah Park, Soh-Jeong Yang, Hee Jin Kim, Juhee Chin, Jee-hoon Roh, Seong Soo A. An p. 39-53

(Letter to the Editor) Amyloid depositions and small vessel disease in patients with cerebral amyloid angiopathy : a case series Yun Jeong Hong, Si Baek Lee, Seong Hoon Kim, Dong Woo Ryu, Yongbang Kim, Jeong Wook Park p. 74-76

Clinical aspects of neurobehavioral symptoms of dementia YoungSoon Yang, Nagaendran Kandiah, SangYun Kim, Yong Tae Kwak p. 54-64

Home-visiting cognitive intervention for the community-dwelling elderly living alone Juyoun Lee, Ae Young Lee, Daejeon Metropolitan Dementia Center p. 65-73

참고문헌 (39건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. 네이버 미소장
2 Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: toward a biological definition of Alzheimer's disease. Alzheimers Dement 2018;14:535-562. 미소장
3 A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers 네이버 미소장
4 Jack CR Jr, Holtzman DM. Biomarker modeling of Alzheimer's disease. Neuron 2013;80:1347-1358. 미소장
5 Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013;12:207-216. 미소장
6 Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010;9:119-128. 미소장
7 Jagust W. Imaging the evolution and pathophysiology of Alzheimer disease. Nat Rev Neurosci 2018;19:687-700. 미소장
8 Donohue MC, Sperling RA, Petersen R, Sun CK, Weiner MW, Aisen PS, et al. Association between elevated brain amyloid and subsequent cognitive decline among cognitively normal persons. JAMA 2017;317:2305-2316. 미소장
9 Dubois B, Epelbaum S, Nyasse F, Bakardjian H, Gagliardi G, Uspenskaya O, et al. Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study. Lancet Neurol 2018;17:335-346. 미소장
10 Adams JN, Lockhart SN, Li L, Jagust WJ. Relationships between tau and glucose metabolism reflect Alzheimer's disease pathology in cognitively normal older adults. Cereb Cortex 2019;29:1997-2009. 미소장
11 Tosun D, Landau S, Aisen PS, Petersen RC, Mintun M, Jagust W, et al. Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals. Brain 2017;140:1499-1512. 미소장
12 Harrison TM, La Joie R, Maass A, Baker SL, Swinnerton K, Fenton L, et al. Longitudinal tau accumulation and atrophy in aging and Alzheimer disease. Ann Neurol 2019;85:229-240. 미소장
13 Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, et al. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain 2017;140:3286-3300. 미소장
14 Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, et al. Entorhinal tau pathology, episodic memory decline, and neurodegeneration in aging. J Neurosci 2018;38:530-543. 미소장
15 Complement activation by human lymphocytes from different lymphoid organs: role of sialic acid and lack of relationship to electrical surface charge. 네이버 미소장
16 Kim SH, Noh MY, Kim HJ, Oh KW, Park J, Lee S, et al. A therapeutic strategy for Alzheimer's disease focused on immune-inflammatory modulation. Dement Neurocogn Disord 2019;18:33-46. 미소장
17 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, et al. TREM2 variants in Alzheimer's disease. N Engl J Med 2013;368:117-127. 미소장
18 Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 2013;368:107-116. 미소장
19 Neumann H, Daly MJ. Variant TREM2 as risk factor for Alzheimer's disease. N Engl J Med 2013;368:182-184. 미소장
20 Wang MJ, Yi S, Han JY, Park SY, Jang JW, Chun IK, et al. Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease. Alzheimers Res Ther 2017;9:98. 미소장
21 Yoo YK, Kim J, Kim G, Kim YS, Kim HY, Lee S, et al. A highly sensitive plasma-based amyloid-β detection system through medium-changing and noise cancellation system for early diagnosis of the Alzheimer's disease. Sci Rep 2017;7:8882. 미소장
22 Park JC, Han SH, Yi D, Byun MS, Lee JH, Jang S, et al. Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease. Brain 2019;142:771-786. 미소장
23 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet 2019;51:414-430. 미소장
24 Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. 네이버 미소장
25 Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, et al. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease. Alzheimers Dement 2019;15:441-452. 미소장
26 Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, et al. Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry. JAMA Netw Open 2019;2:e191350. 미소장
27 Rovelet-Lecrux A, Hannequin D, Guillin O, Legallic S, Jurici S, Wallon D, et al. Frontotemporal dementia phenotype associated with MAPT gene duplication. J Alzheimers Dis 2010;21:897-902. 미소장
28 Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerrière A, Vital A, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006;38:24-26. 미소장
29 α-Synuclein Locus Triplication Causes Parkinson's Disease 네이버 미소장
30 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One 2010;5:e13950. 미소장
31 Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013;45:1452-1458. 미소장
32 Matarin M, Salih DA, Yasvoina M, Cummings DM, Guelfi S, Liu W, et al. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell Reports 2015;10:633-644. 미소장
33 Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, et al. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011;146:37-52. 미소장
34 Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J, et al. Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease. Brain 2017;140:3191-3203. 미소장
35 Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med 2009;361:1651-1661. 미소장
36 Jabbari E, Woodside J, Tan MM, Shoai M, Pittman A, Ferrari R, et al. Variation at the TRIM11 locus modifies progressive supranuclear palsy phenotype. Ann Neurol 2018;84:485-496. 미소장
37 Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, et al. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med 2016;22:46-53. 미소장
38 Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, et al. Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: harmonization for international trials. Alzheimers Dement 2018;14:1077-1087. 미소장
39 CSF1R-related leukoencephalopathy: A major player in primary microgliopathies. 네이버 미소장

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