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Central neurocytoma (CN) has been known as a benign neuronal tumor. In rare cases, CN undergoes malignant transformation to glioblastomas (GBM). Here we examined its cellular origin by characterizing differentiation potential and gene expression of CN-spheroids. First, we demonstrate that both CN tissue and cultured primary cells recapitulate the hierarchal cellular composition of subventricular zone (SVZ), which is comprised of neural stem cells (NSCs), transit amplifying progenitors (TAPs), and neuroblasts. We then derived spheroids from CN which displayed EGFR+/ MASH+ TAP and BLBP+ radial glial cell (RGC) characteristic, and mitotic neurogenesis and gliogenesis by single spheroids were observed with cycling multipotential cells. CN-spheroids expressed increased levels of pluripotency and tumor stem cell genes such as KLF4 and TPD5L1, when compared to their differentiated cells and human NSCs. Importantly, Gene Set Enrichment Analysis showed that gene sets of GBM-Spheroids, EGFR Signaling, and Packaging of Telomere Ends are enriched in CN-spheroids in comparison with their differentiated cells. We speculate that CN tumor stem cells have TAP and RGC characteristics, and upregulation of EGFR signaling as well as downregulation of eph-ephrin signaling have critical roles in tumorigenesis of CN. And their ephemeral nature of TAPs destined to neuroblasts, might reflect benign nature of CN.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Immunosuppression and neuroinflammation in stroke pathobiology Qian Jiang, Christopher R. Stone, Kenneth Elkin, Xiaokun Geng, Yuchuan Ding p. 101-112
(The) pathological role of astrocytic MAOB in Parkinsonism revealed by genetic ablation and over-expression of MAOB Heeyoung An, Jun Young Heo, C. Justin Lee, Min-Ho Nam p. 113-119

Tumor spheroids of an aggressive form of central neurocytoma have transit-amplifying progenitor characteristics with enhanced EGFR and tumor stem cell signaling Hye Young Shin, Kyung-Seok Han, Hyung Woo Park, Yun Hwa Hong, Yona Kim, Hyo Eun Moon, Kwang Woo Park, Hye Ran Park, C. Justin Lee, Kiyoung Lee, Sang Jeong Kim, Man Seung Heo, Sung-Hye Park, Dong Gyu Kim, Sun Ha Paek p. 120-143

β-adrenergic receptor activity in the hippocampal dentate gyrus participates in spatial learning and memory impairment in sleep-deprived rats Huan-Jun Lu, Jing lv p. 144-154
Dynamics of T lymphocyte between the periphery and the brain from the acute to the chronic phase following ischemic stroke in mice Minha Kim, So-Dam Kim, Kyoung In Kim, Eun Hae Jeon, Min Gee Kim, Yu-Ree Lim, Enkhmaa Lkhagva-Yondon, Yena Oh, Kwangmin Na, Young Cheul Chung, Byung Kwan Jin, Yun Seon Song, Myung Shin Jeon p. 155-169

Upregulation of miR-20b protects against cerebral ischemic stroke by targeting thioredoxin interacting protein (TXNIP) Dejiang Yang, Yu Tan, Huanhuan Li, Xiaowei Zhang, Xinming Li, Feng Zhou p. 170-182
Preliminary comparison of subcortical structures in elderly subclinical depression : structural analysis with 3T MRI SangJin Im, Jeonghwan Lee, Siekyeong Kim p. 183-202

참고문헌 (103건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
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