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DA-1241, a novel GPR119 agonist, improves hyperglycaemia by inhibiting hepatic gluconeogenesis and enhancing insulin secretion in diabetic mice / Youjin Kim ; Si Woo Lee ; Hyejin Wang ; Ryeong-Hyeon Kim ; Hyun Ki Park ; Hangkyu Lee ; Eun Seok Kang 1

[요약] 1

INTRODUCTION 1

METHODS 2

RESULTS 4

DISCUSSION 6

SUPPLEMENTARY MATERIALS 9

AUTHOR CONTRIBUTIONS 10

REFERENCES 10

초록보기

Background: We investigated the antidiabetic effects of DA-1241, a novel G protein-coupled receptor (GPR) 119 agonist, in vitro and in vivo.Methods: DA-1241 was administrated to high-fat diet (HFD)-fed C57BL/6J mice for 12 weeks after hyperglycaemia developed. Oral/intraperitoneal glucose tolerance test and insulin tolerance test were performed. Serum insulin and glucagon-like peptide-1 (GLP-1) levels were measured during oral glucose tolerance test. Insulinoma cell line (INS-1E) cells and mouse islets were used to find whether DA-1241 directly stimulate insulin secretion in beta cell. HepG2 cells were used to evaluate the gluconeogenesis and autophagic process. Autophagic flux was evaluated by transfecting microtubule-associated protein 1 light chain 3-fused to green fluorescent protein and monomeric red fluorescent (mRFP-GFP-LC3) expression vector to HepG2 cells.Results: Although DA-1241 treatment did not affect body weight gain and amount of food intake, fasting blood glucose level decreased along with increase in GLP-1 level. DA-1241 improved only oral glucose tolerance test and showed no effect in intraperitoneal glucose tolerance test. No significant effect was observed in insulin tolerance test. DA-1241 did not increase insulin secretion in INS-1E cell and mouse islets. DA-1241 reduced triglyceride content in the liver thereby improved fatty liver. Additionally, DA-1241 reduced gluconeogenic enzyme expression in HepG2 cells and mouse liver. DA-1241 reduced autophagic flow in HepG2 cells.Conclusion: These findings suggested that DA-1241 augmented glucose-dependent insulin release via stimulation of GLP-1 secretion, and reduced hepatic gluconeogenesis, which might be associated with autophagic blockage, leading to improved glycaemic control.

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기사명 저자명 페이지 원문 목차
Not control but conquest : strategies for the remission of type 2 diabetes mellitus Jinyoung Kim, Hyuk-Sang Kwon p. 165-180

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Pathophysiologic mechanisms and potential biomarkers in diabetic kidney disease Chan-Young Jung, Tae-Hyun Yoo p. 181-197

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Peripheral neuropathy phenotyping in rat models of type 2 diabetes mellitus : evaluating uptake of the neurodiab guidelines and identifying future directions Md Jakir Hossain, Michael D. Kendig, Meg E. Letton, Margaret J. Morris, Ria Arnold p. 198-221

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Glial and vascular cell regulation of the blood-brain barrier in diabetes Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou p. 222-238

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Links between thyroid disorders and glucose homeostasis Young Sil Eom, Jessica R. Wilson, Victor J. Bernet p. 239-256

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Impact of COVID-19 lockdown on the metabolic control parameters in patients with diabetes mellitus : a systematic review and meta-analysis Ifan Ali Wafa, Nando Reza Pratama, Nurizzah Farahiyah Sofia, Elsha Stephanie Anastasia, Tiffany Konstantin, Maharani Ayuputeri Wijaya, M. Rifqi Wiyono, Lilik Djuari, Hermina Novida p. 260-272

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Performance of diabetes and kidney disease screening scores in contemporary United States and Korean populations Liela Meng, Keun-Sang Kwon, Dae Jung Kim, Yong-ho Lee, Jeehyoung Kim, Abhijit V. Kshirsagar, Heejung Bang p. 273-285

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Mean and variability of lipid measurements and risk for development of subclinical left ventricular diastolic dysfunction Jiyun Park, Mira Kang, Jiyeon Ahn, Min Young Kim, Min Sun Choi, You-Bin Lee, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Jeong Hoon Yang, Sang-Man Jin p. 286-296

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Prevalence of type 2 diabetes mellitus among Korean children, adolescents, and adults younger than 30 years : changes from 2002 to 2016 Yong Hee Hong, In-Hyuk Chung, Kyungdo Han, Sochung Chung p. 297-306

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Iron overload and the risk of diabetes in the general population : results of the Chinese health and nutrition survey cohort study He Gao, Jinying Yang, Wenfei Pan, Min Yang p. 307-318

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SUDOSCAN in combination with the Michigan neuropathy screening instrument is an effective tool for screening diabetic peripheral neuropathy Tae Jung Oh, Yoojung Song, Hak Chul Jang, Sung Hee Choi p. 319-326

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Changes in patterns of physical activity and risk of heart failure in newly diagnosed diabetes mellitus patients Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee p. 327-336

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DA-1241, a novel GPR119 agonist, improves hyperglycaemia by inhibiting hepatic gluconeogenesis and enhancing insulin secretion in diabetic mice Youjin Kim, Si Woo Lee, Hyejin Wang, Ryeong-Hyeon Kim, Hyun Ki Park, Hangkyu Lee, Eun Seok Kang p. 337-348

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참고문헌 (48건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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