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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
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결과 내 검색 동의어 포함

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Background and Objectives A recent study revealed that calcitonin gene-related protein (CGRP) plays an important role in inflammatory airway diseases. However, the influence of CGRP on chronic rhinosinusitis (CRS) has not been studied. This study investigated the expression, activity, and potential pathogenic role of CGRP in patients with CRS with nasal polyposis (CRSwNP).

Subjects and Method Patients with CRSwNP and control subjects were enrolled. The CRSwNP group was divided according to the presence of eosinophilic polyps and non-eosinophilic polyps. Nasal polyps (NPs) and uncinate tissues (UTs) from patients with CRSwNP and UTs from control subjects were obtained to investigate the expression of α-/β-CGRP and chromogranin A. In addition, the expression patterns of cytokines following exposure to exogenous CGRP were analyzed in dispersed nasal polyp cells (DNPCs) from patients with eosinophilic or non-eosinophilic CRSwNP. The effects of CGRP on lipopolysaccharide (LPS)-induced nuclear factor-kappa light chain enhancer of activated B cells (NF-κB) signalingchange were evaluated in THP-1 cells.

Results The expression of α-/β-CGRP and number of CGRP-producing cells were significantly higher in NPs from patients with CRSwNP than in UTs from controls. Exogenous CGRP decreased the expression of inflammatory cytokines and increased that of the anti-inflammatory cytokines in DNPCs from patients with eosinophilic nasal polyps (EPs) and also increased the expression of tissue remodeling-related and anti-inflammatory cytokines in DNPCs from patients with non-eosinophilic nasal polyps (N-EPs). CGRP inhibited the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (IκB) phosphorylation and NF-κB translocation in LPS-stimulated M1 macrophages.

Conclusion CGRP expression in NPs may play a significant role in nasal polypogenesis through inflammatory modulation, and it could be a future target to modulate certain aspects of CRSwNP.

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이관 기능 검사 = Eustachian tube function test 이전미, 이현진 p. 193-201

전상방 사분면을 침범한 고막 천공을 가진 만성중이염 환자에게 시행한 Scutum 전방 고정 고실성형술의 결과 = Outcomes of anterior scutum-anchoring tympanoplasty for reconstruction of tympanic membrane perforation extending to anterosuperior quadrant 홍승우, 정성욱 p. 202-207

Expression and role of calcitonin gene-related peptide in patients with chronic rhinosinusitis with nasal polyposis = 비용을 동반한 만성비부비동염 환자에서 Calcitonin Gene-Related Peptide의 발현 및 역할 Jaein Chung, Seulgi Lee, Min Gyu Kim, Se Yeon Im, Seung Hyeon Choi, Soo Kyoung Park, Ki-Sang Rha, Yong Min Kim p. 208-219

COVID-19 환자의 변형된 경피적 기관절개술의 특성 분석 : Characteristics of hybrid modified percutaneous dilatational tracheostomy in patients with COVID-19 : a single institutional experience over 1 year / 1년간의 단일 기관 경험 김민지, 최연수, 김정수, 이진수, 김지원 p. 220-225

Zenker 게실 환자에서 내시경적 접근법을 통해 Energy Device를 이용한 게실절개술 1예 = Transoral endoscopic diverticulostomy of Zenker’s diverticulum with energy device 김현범, 임연희, 안희선, 박영학 p. 226-230

유사한 조직소견으로 인해 사르코이드증과의 감별이 어려웠던 비인두 결핵 1예 = A case of nasopharyngeal tuberculosis which was difficult to differentiate from sarcoidosis 장동혁, 김호찬, 홍영옥, 김지선 p. 231-236

미로 내 신경초종으로 인한 일측성 심도 난청 환자에서 시행된 인공와우 이식술 2예 = Two cases of cochlear implantation in patients with unilateral profound hearing loss due to intralabyrinthine schwannoma 하승철, 최지원, 정종우 p. 237-241

미단부 비중격성형술 : Caudal septoplasty : a useful cartilage stump on anterior nasal spine / 전비극위 연골 그루터기의 유용성 진명호, 최명수 p. 242-246

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