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Contents

Comparison of prevailing insulin regimens at different time periods in hospitalized patients : a real-world experience from a tertiary hospital / Sun Joon Moon ; Hun Jee Choe ; Soo Heon Kwak ; Hye Seung Jung ; Kyong Soo Park ; Young Min Cho 1

[요약] 1

INTRODUCTION 1

METHODS 2

RESULTS 4

DISCUSSION 8

SUPPLEMENTARY MATERIALS 9

AUTHOR CONTRIBUTIONS 9

REFERENCES 9

초록보기

Background: Prevailing insulin regimens for glycemic control in hospitalized patients have changed over time. We aimed to determine whether the current basal-bolus insulin (BBI) regimen is superior to the previous insulin regimen, mainly comprising split-mixed insulin therapy.Methods: This was a single tertiary center, retrospective observational study that included non-critically ill patients with type 2 diabetes mellitus who were treated with split-mixed insulin regimens from 2004 to 2007 (period 1) and with BBI from 2008 to 2018 (period 2). Patients from each period were analyzed after propensity score matching. The mean difference in glucose levels and the achievement of fasting and preprandial glycemic targets by day 6 of admission were assessed. The total daily insulin dose, incidence of hypoglycemia, and length of hospital stay were also evaluated.Results: Among 244 patients from each period, both fasting glucose (estimated mean±standard error, 147.4±3.1 mg/dL vs. 129.4±3.2 mg/dL, P<0.001, day 6) and preprandial glucose (177.7±2.8 mg/dL vs. 152.8±2.8 mg/dL, P<0.001, day 6) were lower in period 2 than in period 1. By day 6 of hospital admission, 42.6% and 67.2% of patients achieved a preprandial glycemic target of <140 mg/dL in periods 1 and 2, respectively (relative risk, 2.00; 95% confidence interval, 1.54 to 2.59), without an increased incidence of hypoglycemia. Length of stay was shorter in period 2 (10.23±0.26 days vs. 8.70±0.26 days, P<0.001).Conclusion: BBI improved glycemic control in a more efficacious manner than a split-mixed insulin regimen without increasing the risk of hypoglycemia in a hospital setting.

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기사명 저자명 페이지 원문 목차
Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management : consensus statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hypertension Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song ... [et al.] p. 355-376

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Comprehensive understanding for application in Korean patients with type 2 diabetes mellitus of the consensus statement on carbohydrate-restricted diets by Korean Diabetes Association, Korean Society for the Study of Obesity, and Korean Society of Hypertension Jong Han Choi, Jee-Hyun Kang, Suk Chon p. 377-390

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Lifestyle interventions for non-obese patients both with, and at risk, of non-alcoholic fatty liver disease Xin-Lei Zhang, Ting-Yao Wang, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng p. 391-401

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Exercise, mitohormesis, and mitochondrial ORF of the 12S rRNA type-C (MOTS-c) Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim p. 402-413

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Diabetes fact sheet in Korea 2021 Jae Hyun Bae, Kyung-Do Han, Seung-Hyun Ko, Ye Seul Yang, Jong Han Choi, Kyung Mook Choi, Hyuk-Sang Kwon, Kyu Chang Won p. 417-426

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Association of metabolic syndrome with COVID-19 in the Republic of Korea Woo-Hwi Jeon, Jeong-Yeon Seon, So-Youn Park, In-Hwan Oh p. 427-438

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Comparison of prevailing insulin regimens at different time periods in hospitalized patients : a real-world experience from a tertiary hospital Sun Joon Moon, Hun Jee Choe, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho p. 439-450

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Identification of key genes and pathways in peripheral blood mononuclear cells of type 1 diabetes mellitus by integrated bioinformatics analysis Xing Li, Mingyu Liao, Jiangheng Guan, Ling Zhou, Rufei Shen, Min Long, Jiaqing Shao p. 451-463

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Current status of low-density lipoprotein cholesterol target achievement in patients with type 2 diabetes mellitus in Korea compared with recent guidelines Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko ... [et al.] p. 464-475

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Normalized creatinine-to-cystatin C ratio and risk of diabetes in middle-aged and older adults : the China health and retirement longitudinal study Shanhu Qiu, Xue Cai, Bo Xie, Yang Yuan, Zilin Sun, Tongzhi Wu p. 476-485

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Sex differences of visceral fat area and visceral-to-subcutaneous fat ratio for the risk of incident type 2 diabetes mellitus Eun Hee Kim, Hong-Kyu Kim, Min Jung Lee, Sung-Jin Bae, Jaewon Choe, Chang Hee Jung, Chul-Hee Kim, Joong-Yeol Park, Woo Je Lee p. 486-498

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Influence of pre-pregnancy underweight body mass index on fetal abdominal circumference, estimated weight, and pregnancy outcomes in gestational diabetes mellitus Minji Kim, Kyu-Yeon Hur, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh p. 499-505

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GPR40 agonism modulates inflammatory reactions in vascular endothelial cells Joo Won Kim, Eun Roh, Kyung Mook Choi, Hye Jin Yoo, Hwan-Jin Hwang, Sei Hyun Baik p. 506-511

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참고문헌 (50건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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