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Six ansamycin derivatives were isolated from the culture broth of Streptomyces sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered O-heterocyclic moiety. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The structures of 1-4 were elucidated using NMR and HRESIMS experiments, and the absolute configuration was established by the Mosher’s method. Compound 2 exhibited mild cytotoxicity against five cancer cell lines with IC₅₀ values ranging from 24.60 ± 3.37 μM to 49.93 ± 4.52 μM.

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Safety assessment systems for microbial starters derived from fermented foods Sojeong Heo, Tao Kim, Hong-Eun Na, Gawon Lee, Jung-Hyun Park, Hee-Jung Park, Do-Won Jeong p. 1219-1225

(The) functional roles of Lactobacillus acidophilus in different physiological and pathological processes Huijuan Gao, Xin Li, Xiatian Chen, Deng Hai, Chuang Wei, Lei Zhang, Peifeng Li p. 1226-1233

Propionate attenuates growth of oral streptococci through enhancing methionine biosynthesis Taehwan Park, Jintaek Im, A Reum Kim, Dongwook Lee, Sungho Jeong, Cheol-Heui Yun, Seung Hyun Han p. 1234-1244

Acceleration of mesenchymal-to-epithelial transition (MET) during direct reprogramming using natural compounds Ji-Hye Seo, Si Won Jang, Young-Joo Jeon, So Young Eun, Yean Ju Hong, Jeong Tae Do, Jung-il Chae, Hyun Woo Choi p. 1245-1252

Bavachin suppresses alpha-hemolysin expression and protects mice from pneumonia infection by Staphylococcus aureus Ye Tao, Dazhong Sun, Xinran Ren, Yicheng Zhao, Hengjian Zhang, Tao Jiang, Jiyu Guan, Yong Tang, Wu Song, Shuqiang Li, Li Wang p. 1253-1261

Identification and validation of novel biomarkers and potential targeted drugs in cholangiocarcinoma : bioinformatics, virtual screening, and biological evaluation Jiena Wang, Weiwei Zhu, Junxue Tu, Yihui Zheng p. 1262-1274

Soil microbial communities associated with three Arctic plants in different local environments in Ny-Ålesund, Svalbard Deokjoo Son, Eun Ju Lee p. 1275-1283

Isovitexin protects mice from methicillin-resistant Staphylococcus aureus-induced pneumonia by targeting sortase A Lili Tian, Xinliang Wu, Hangqian Yu, Fengying Yang, Jian Sun, Tiezhong Zhou, Hong Jiang p. 1284-1291

Effects of long-term fertilizer practices on rhizosphere soil autotrophic CO2-fixing bacteria under double rice ecosystem in Southern China Haiming Tang, Li Wen, Lihong Shi, Chao Li, Kaikai Cheng, Weiyan Li, Xiaoping Xiao p. 1292-1298

Hygrolansamycins A-D, O-heterocyclic macrolides from Streptomyces sp. KCB17JA11 Jun-Pil Jang, Byeongsan Lee, Kyung Taek Heo, Tae Hoon Oh, Hyeok-Won Lee, Sung-Kyun Ko, Bang Yeon Hwang, Jae-Hyuk Jang, Young-Soo Hong p. 1299-1306

Prevalence and characteristics of Salmonella spp. isolated from raw chicken meat in the Republic of Korea Youngho Koh, Yunyoung Bae, Yu-Si Lee, Dong-Hyun Kang, Soon Han Kim p. 1307-1314

Effects of probiotic fermented fruit juice-based biotransformation by lactic acid bacteria and Saccharomyces boulardii CNCM I-745 on anti-salmonella and antioxidative properties Wanida Laosee, Duangporn Kantachote, Worrapanit Chansuwan, Nualpun Sirinupong p. 1315-1324

Mixotrophic cultivation of a native cyanobacterium, Pseudanabaena mucicola GO0704, to produce phycobiliprotein and biodiesel Shin Myung Kim, Eun Hee Bae, Jee Young Kim, Jae-Shin Kang, Yoon-E Choi p. 1325-1334

Expression and immunogenicity of SARS-CoV-2 virus-like particles based on recombinant truncated HEV-3 ORF2 capsid protein Yong-Fei Zhou, Jiao-Jiao Nie, Chao Shi, Ke Ning, Yu-Feng Cao, Yanbo Xie, Hongyu Xiang, Qiuhong Xie p. 1335-1343

KIF26B-AS1 regulates TLR4 and activates the TLR4 signaling pathway to promote malignant progression of laryngeal cancer Li Li, Jiahui Han, Shujia Zhang, Chunguang Dong, Xiang Xiao p. 1344-1354

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