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Unusual biclonal IgA plasma cell myeloma with aberrant expression of high-risk immunophenotypes : first report of a new diagnostic and clinical challenge / Carlos A. Monroig-Rivera ; Clara N. Finch Cruz 1

[요약] 1

CASE REPORT 1

DISCUSSION 2

Author Contributions 5

References 6

초록보기

IgA plasma cell myeloma (PCM) has been linked to molecular abnormalities that confer a higher risk for adverse patient outcomes. However, since IgA PCM only accounts for approximately 20% of all PCM, there are very few reports on high-risk IgA PCM. Moreover, no such reports are found on the more infrequent biclonal IgA PCM. Hence, we present a 65-year-old Puerto Rican female with acute abdominal pain, concomitant hypercalcemia, and acute renal failure. Protein electrophoresis with immunofixation found high IgA levels and detected a biclonal IgA gammopathy with kappa specificity. Histomorphologically, bone marrow showed numerous abnormal plasma cells (32%) replacing over 50% of the marrow stroma. Immunophenotyping analysis detected CD45-negative plasma cells aberrantly expressing CD33, CD43, OCT-2, and c-MYC. Chromosomal analysis revealed multiple abnormalities including the gain of chromosome 1q. Thus, we report on an unusual biclonal IgA PCM and the importance of timely diagnosing aggressive plasma cell neoplasms.

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Unusual biclonal IgA plasma cell myeloma with aberrant expression of high-risk immunophenotypes : first report of a new diagnostic and clinical challenge Carlos A. Monroig-Rivera, Clara N. Finch Cruz p. 132-137

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참고문헌 (18건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Habermehl GK, Nakashima MO, Cotta CV. IgA plasma cell neoplasms are characterized by poorer long-term survival and increased genomic complexity compared to IgG neoplasms. Ann Diagn Pathol 2020; 44: 151449. 미소장
2 McKenna RW, Kroft SH, Linden MA. Plasma cell neoplasms. In:Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, eds. Hematopathology. 2nd ed. Philadelphia: Elsevier, 2017; 473-506. 미소장
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12 Suo L, Liu S, Vega I, Thrall M. Extramedullary multiple myeloma involving the liver and periportal lymph node, diagnosed by EUSFNA in a patient with cirrhosis. Diagn Cytopathol 2020; 48: 657-61. 미소장
13 Yamane F, Ohta R, Sano C. Left lower abdominal pain as an initial symptom of multiple myeloma. Cureus 2021; 13: e20652. 미소장
14 Muchtar E, Gertz MA. The colorful landscape of multiple myeloma. Leuk Lymphoma 2019; 60: 2099-100. 미소장
15 Ning X, Wei Y, Wei X, et al. CD43 expression is an adverse prognostic factor in newly diagnosed multiple myeloma. Blood 2021; 138(Suppl 1): 4753. 미소장
16 Toman I, Loree J, Klimowicz AC, et al. Expression and prognostic significance of Oct2 and Bob1 in multiple myeloma: implications for targeted therapeutics. Leuk Lymphoma 2011; 52: 659-67. 미소장
17 Kodali S, Yu H, Cerny J. Assessing MYC expression in multiple myeloma. J Hematol Thrombo Dis 2015; 3: e119. 미소장
18 Castaneda-Avila MA, Ortiz-Ortiz KJ, Torres-Cintron CR, Birmann BM, Epstein MM. Trends in cause of death among patients with multiple myeloma in Puerto Rico and the United States SEER population, 1987-2013. Int J Cancer 2020; 146: 35-43. 미소장

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