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Purpose: Junctional adhesion molecule (JAM)-A is an immunoglobulin-like molecule that colocalizes with tight junctions (TJs) in the endothelium and epithelium. It is also found in blood leukocytes and platelets. The biological significance of JAM-A in asthma, as well as its clinical potential as a therapeutic target, are not well understood. The aim of this study was to elucidate the role of JAM-A in a mouse model of asthma, and to determine blood levels of JAM-A in asthmatic patients.

Materials and Methods: Mice sensitized and challenged with ovalbumin (OVA) or saline were used to investigate the role of JAM-A in the pathogenesis of bronchial asthma. In addition, JAM-A levels were measured in the plasma of asthmatic patients and healthy controls. The relationships between JAM-A and clinical variables in patients with asthma were also examined.

Results: Plasma JAM-A levels were higher in asthma patients (n=19) than in healthy controls (n=12). In asthma patients, the JAM-A levels correlated with forced expiratory volume in 1 second (FEV1%), FEV1/forced vital capacity (FVC), and the blood lymphocyte proportion. JAM-A, phospho-JNK, and phospho-ERK protein expressions in lung tissue were significantly higher in OVA/OVA mice than in control mice. In human bronchial epithelial cells treated with house dust mite extracts for 4h, 8h, and 24h, the JAM-A, phospho-JNK, and phospho-ERK expressions were increased, as shown by Western blotting, while the transepithelial electrical resistance was reduced.

Conclusion: These results suggest that JAM-A is involved in the pathogenesis of asthma, and may be a marker for asthma.

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Cost-effectiveness of age-expanding strategy of latent tuberculosis infection treatment in household contacts in South Korea Hyunwoo Cho, Jeongjoo Seok, Youngmok Park, Hee Jin Kim, Eun Hye Lee, Jungeun Park, Dong Ah Park, Young Ae Kang, Jeehyun Lee p. 366-374, [1-18]

Impact of the junction adhesion molecule-A on asthma Min-Hyeok An, Pureun-Haneul Lee, Seon-Muk Choi, DaYeon Hwang, Jung-Hyun Kim, Meung Chul Park, Shinhee Park, Ae-Rin Baek, An-Soo Jang p. 375-383

Radiologic assessment of lung edema score as a predictor of clinical outcome in children with acute respiratory distress syndrome Chang Hoon Han, Mireu Park, Hamin Kim, Yun Young Roh, Soo Yeon Kim, Jong Deok Kim, Min Jung Kim, Yong Ju Lee, Kyung Won Kim, Yoon Hee Kim p. 384-394, [1-6]

Short-term outcomes and cost-effectiveness between long-course chemoradiation and short-course radiotherapy for locally advanced rectal cancer Min Soo Cho, Hyeon Woo Bae, Jee Suk Chang, Seung Yoon Yang, Tae Hyun Kim, Woong Sub Koom, Sang Joon Shin, Gyu-Seog Choi, Nam Kyu Kim p. 395-403

Severe systemic reactions following bee sting injuries in Korea Ji Hwan Lee, Min Joung Kim, Yoo Seok Park, EungNam Kim, Hyun Soo Chung, Sung Phil Chung p. 404-412

참고문헌 (32건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, Falkow S. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 2003;300:1430-4. 미소장
2 Martìn-Padura I, Lostaglio S, Schneemann M, Williams L, Romano M, Fruscella P, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998;142:117-27. 미소장
3 Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. J Biol Chem 2000;275:27979-88. 미소장
4 Bazzoni G, Martinez-Estrada OM, Orsenigo F, Cordenonsi M, Citi S, Dejana E. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 2000;275:20520-6. 미소장
5 Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, et al. A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions. J Biol Chem 2000;275:34750-6. 미소장
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7 Arrate MP, Rodriguez JM, Tran TM, Brock TA, Cunningham SA. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. J Biol Chem 2001;276:45826-32. 미소장
8 Liang TW, Chiu HH, Gurney A, Sidle A, Tumas DB, Schow P, et al. Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol 2002;168:1618-26. 미소장
9 Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, et al. The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 2002;196:679-91. 미소장
10 Hirabayashi S, Tajima M, Yao I, Nishimura W, Mori H, Hata Y. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. Mol Cell Biol 2003;23:4267-82. 미소장
11 Kakogiannos N, Ferrari L, Giampietro C, Scalise AA, Maderna C, Ravà M, et al. JAM-A acts via C/EBP-α to promote claudin-5 expression and enhance endothelial barrier function. Circ Res 2020;127:1056-73. 미소장
12 Denk S, Wiegner R, Hönes FM, Messerer DA, Radermacher P, Weiss M, et al. Early detection of junctional adhesion molecule-1(JAM-1) in the circulation after experimental and clinical polytrauma. Mediators Inflamm 2015;2015:463950. 미소장
13 Zhang M, Luo W, Huang B, Liu Z, Sun L, Zhang Q, et al. Overexpression of JAM-A in non-small cell lung cancer correlates with tumor progression. PLoS One 2013;8:e79173. 미소장
14 Kaplan A, van Boven JFM, Ryan D, Tsiligianni I, Bosnic-Anticevich S; REG Adherence Working Group. GINA 2020: potential impacts, opportunities, and challenges for primary care. J Allergy Clin Immunol Pract 2021;9:1516-9. 미소장
15 Mitchell LA, Ward C, Kwon M, Mitchell PO, Quintero DA, Nusrat A, et al. Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function. Am J Pathol 2015;185:372-86. 미소장
16 Thölmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, et al. JAM-A interacts with α3β1 integrin and tetraspanins CD151and CD9 to regulate collective cell migration of polarized epithelial cells. Cell Mol Life Sci 2022;79:88. 미소장
17 Bonilha CS, Benson RA, Scales HE, Brewer JM, Garside P. Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation. Immunol Lett 2021;235:32-40. 미소장
18 Brozat JF, Brandt EF, Stark M, Fischer P, Wirtz TH, Flaßhove A, et al. JAM-A is a multifaceted regulator in hepatic fibrogenesis, supporting LSEC integrity and stellate cell quiescence. Liver Int 2022;42:1185-203. 미소장
19 Czubak-Prowizor K, Babinska A, Swiatkowska M. The F11 receptor (F11R)/junctional adhesion molecule-A (JAM-A) (F11R/JAMA)in cancer progression. Mol Cell Biochem 2022;477:79-98. 미소장
20 Raghavan S, Kenchappa DB, Leo MD. SARS-CoV-2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity. Front Cardiovasc Med 2021;8:687783. 미소장
21 Wesslau KP, Stein A, Kasper M, Barth K. P2X7 receptor indirectly regulates the JAM-A protein content via modulation of GSK-3β. Int J Mol Sci 2019;20:2298. 미소장
22 Magara K, Takasawa A, Osanai M, Ota M, Tagami Y, Ono Y, et al. Elevated expression of JAM-A promotes neoplastic properties of lung adenocarcinoma. Cancer Sci 2017;108:2306-14. 미소장
23 Wang Y, Yu L, Wang T. MicroRNA-374b inhibits the tumor growth and promotes apoptosis in non-small cell lung cancer tissue through the p38/ERK signaling pathway by targeting JAM-2. J Thorac Dis 2018;10:5489-98. 미소장
24 Lee PH, Choi S, An M, Jang AS. Recent patents in allergy and immunology:a quantitative real-time polymerase chain reaction method for diagnosing asthma and asthma exacerbation. Clin Transl Allergy 2022;12:e12136. 미소장
25 Lee PH, Choi SM, An MH, Hwang DY, Park S, Baek AR, et al. Nectin4is a potential therapeutic target for asthma. Front Immunol 2022;13:1049900. 미소장
26 Park S, Lee PH, Baek AR, Park JS, Lee J, Park SW, et al. Association of the tight junction protein claudin-4 with lung function and exacerbations in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2021;16:2735-40. 미소장
27 Kim BG, Lee PH, Lee SH, Baek AR, Park JS, Lee J, et al. Impact of the endothelial tight junction protein claudin-5 on clinical profiles of patients with COPD. Allergy Asthma Immunol Res 2018;10:533-42. 미소장
28 Díaz-Coránguez M, Liu X, Antonetti DA. Tight junctions in cell proliferation. Int J Mol Sci 2019;20:5972. 미소장
29 Lee PH, Park S, Lee YG, Choi SM, An MH, Jang AS. The impact of environmental pollutants on barrier dysfunction in respiratory disease. Allergy Asthma Immunol Res 2021;13:850-62. 미소장
30 Lee YG, Lee PH, Choi SM, An MH, Jang AS. Effects of air pollutants on airway diseases. Int J Environ Res Public Health 2021;18:9905. 미소장
31 Lee YG, Lee SH, Hong J, Lee PH, Jang AS. Titanium dioxide particles modulate epithelial barrier protein, claudin 7 in asthma. Mol Immunol 2021;132:209-16. 미소장
32 Lee PH, Kim BG, Park MK, Hong J, Lee YG, Jang AS. The impact of diesel exhaust particles on tight junctional proteins on nose and lung in a mouse model. Allergy Asthma Immunol Res 2021;13:350-52. 미소장

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