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Epidermal growth factor receptor (EGFR) is transported into the nucleus during irradiation therapy and can cause the radiation resistance. It has been shown that irradiation activates EGFR transport to the nuclear by karyopherin alpha (KPNA) in the classical pathway, whereas ligand‐activated EGFR binds with karyopherin subunit beta 1 (KPNB1). Phosphorylation of T654 located within the nuclear localization signal (NLS) of EGFR is known to activate radiation‐induced nuclear EGFR transport. Therefore, we investigated the binding affinities between the NLS peptides of EGFR ( 645 RRRHIVRKR X LRR 657 ) and KPNA using a single‐molecule pull‐down assay in this study. We also showed the possible assay system for developing small molecules to modulate nuclear EGFR transport by high throughput screening, which potentially reduces the resistance during radiation therapy.

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기사명 저자명 페이지 원문 목차
Toward rapid and sensitive point-of-care diagnosis with surface-enhanced Raman scattering-based optofluidic systems Younju Joung, Sohyun Park, Binnam Kang, Jaebum Choo p. 718-727
Static headspace gas chromatography-mass spectrometry for volatile organic compounds in bovine milk samples Dokyung Kwon, Eunbi Lee, Huu-Quang Nguyen, Hanbyeol Jang, Jeongkwon Kim p. 728-735
Simulation studies on the dynamic heterogeneity of organic ionic plastic crystals Hyungshick Park, Chung Bin Park, Bong June Sung p. 736-749
Covalent adaptive polymer networks for switchable adhesives Hwi Hyun Moon, Inhwan Cha, Hend A. Hegazy, Kyung-su Kim, Changsik Song p. 750-767
Determination of binding affinities between nuclear localization signal peptides of irradiated EGFR and KPNA using single-molecule pull-down assay and development of assay system for inhibitor screening Jiwon Oh, Namwuk Park, Seung Wook Ham p. 768-771
Integrated continuous-flow/batch protocol for ortho-selective alkynylation of (hetero)aryl tosylates Eun-Hae Ju, Min-Jung Lee, Jiwoo Song, Yong-Ju Kwon, Won-Suk Kim p. 772-776
Ultraviolet photodissociation spectra of singly protonated hexapeptides DYYVVR, DYFVVR, and DFYVVR at room temperature Hyo Nam Jeon, Jang Han Kwon, Hyuk Kang p. 777-779
Gas sorption properties of a new Zn-BTB metal–organic framework with permanent porosity In-Hwan Choi, Ja-Min Gu, Hyun-Chul Kim, Youngmee Kim, Seong Huh p. 780-787
KHC2O4·B(OH)3 : a nonlinear optical crystal with large birefringence in the short-wavelength ultraviolet region Yang Li, Jihyun Lee, Kang Min Ok p. 788-793
Manufacture of electrospun porous PLA fiber-type film coated with CMC and its anti-adhesion efficiency in white mice Sangmun Choi, Kyu Jin Chung, Youngjung Kim, Daeik Kim, Sun Jin Hwang, Su Ho Bae, Keon Sang Ryoo p. 794-801

참고문헌 (21건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 N. Normanno, A. De Luca, C. Bianco, L. Strizzi, M. Mancino, M. R. Maiello, A. Carotenuto, G. De Feo, F. Caponigro, D. S. Salomon, Gene 2006, 366, 2. 미소장
2 D. A. Sabbah, R. Hajjo, K. Sweidan, Curr. Top. Med. Chem. 2020, 20, 815. 미소장
3 T. M. Brand, M. Iida, N. Luthar, M. M. Starr, E. J. Huppert, D. L. Wheeler, Radiother. Oncol. 2013, 108, 370. 미소장
4 G. Caldieri, M. G. Malabarba, P. P. Di Fiore, S. Sigismund, Prog. Mol. Subcell. Biol. 2018, 57, 235. 미소장
5 S. Sigismund, D. Avanzato, L. Lanzetti, Mol. Oncol. 2018, 12, 3. 미소장
6 J. Ortega, J. Y. Li, S. Lee, D. Tong, L. Gu, G. M. Li, Proc. Natl. Acad. Sci. U S A. 2015, 112, 5667. 미소장
7 M. Oshi, S. Gandhi, Y. Tokumaru, L. Yan, A. Yamada, R. Matsuyama, T. Ishikawa, I. Endo, K. Takabe, Am. J. Cancer Res. 2021, 11, 5094. 미소장
8 D. Singh, B. K. Attri, R. K. Gill, J. Bariwal, Mini. Rev, Med. Chem. 2016, 16, 1134. 미소장
9 B. Cautain, R. Hill, N. de Pedro, W. Link, FEBS J. 2015, 282, 445. 미소장
10 A. Lange, R. E. Mills, C. J. Lange, M. Stewart, S. E. Devine, A. H. Corbett, J. Biol. Chem. 2007, 282, 5101. 미소장
11 R. Nakada, H. Hirano, Y. Matsuura, Sci. Rep. 2015, 12, 15055. 미소장
12 S. Ha, J. Jeong, J. Oh, S. Rhee, S. W. Ham, ChemBioChem 2018, 19, 131. 미소장
13 D. G. Gilyazova, A. A. Rosenkranz, P. V. Gulak, V. G. Lunin, O. V. Sergienko, Y. V. Khramtsov, K. N. Timofeyev, M. A. Grin, A. F. Mironov, A. B. Rubin, G. P. Georgiev, A. S. Sobolev, Cancer Res. 2006, 66, 10534. 미소장
14 Y. Yuan, S. Chen, T. Paunesku, S. C. Gleber, W. C. Liu, C. B. Doty, R. Mak, J. Deng, Q. Jin, B. Lai, K. Brister, C. Flachenecker, C. Jacobsen, S. Vogt, G. E. Woloschak, ACS Nano 2013, 7, 10502. 미소장
15 D. Xu, A. Farmer, Y. M. Chook, Curr. Opin. Struct. Biol. 2010, 20, 782. 미소장
16 K. Dittmann, C. Mayer, B. Fehrenbacher, M. Schaller, R. Kehlbach, H. P. Rodemann, FEBS Lett. 2010, 584, 3878. 미소장
17 E. KeithBaylis, C. D. Campbell, J. G. Dingwall, J. Chem. Soc. Perkin Trans. 1984, 1, 2845. 미소장
18 E. Sijbesma, B. A. Somsen, G. P. Miley, I. A. Leijten-van de Gevel, L. Brunsveld, M. R. Arkin, C. Ottmann, ACS Chem. Biologia 2020, 15, 3143. 미소장
19 K. Dittmann, C. Mayer, R. Kehlbach, H. P. Rodemann, Mol. Cancer. 2008, 12, 69. 미소장
20 J. He, Z. Huang, L. Han, Y. Gong, C. Xie, Int. J. Oncol. 2021, 59, 90. 미소장
21 H. Wei, Z. Zhu, L. Lu, Folia. Histochem. Cytobiol. 2017, 55, 43. 미소장

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