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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Purpose Heterogeneous human epidermal growth factor receptor 2 (HER2) overexpression in gastric cancer may lead to a misdiagnosis of HER2 status. Accurate assessment of HER2 status is essential for optimal treatment as novel HER2-directed agents are being investigated in various clinical settings. We evaluated the usefulness of HER2 re-assessment following progression on first-line treatment in initially HER2-negative advanced gastric cancer (AGC) patients. Materials and Methods We enrolled 177 patients with baseline HER2-negative AGC and performed HER2 re-assessment after progression on first-line treatment from February 2012 to June 2016 at Asan Medical Center, Seoul, Korea. The re-assessed HER2 status was analyzed with baseline HER2 status and clinical characteristics. Results The median age was 54 years (range, 24 to 80 years), and 123 patients (69.5%) were men. Seven patients (4.0%) were HER2-positive on the re-assessment. Patients with baseline HER2 negativity confirmed by a single test (n=100) had a higher HER2-positive re-assessment rate compared to those who had repeated baseline testing (n=77) (5.0% vs. 2.6%). Among the patients with single baseline HER2 testing, the rate was higher in patients with baseline HER2 immunohistochemistry (IHC) 1+ compared to those with IHC 0 (13.4% vs. 3.6%). Conclusion Overall, 4.0% of patients with baseline HER2-negative AGC were HER2-positive on re-assessment, and the HER2-positive re-assessment rate was higher among patients who had a single test at baseline. HER2 re assessment may be considered for initially HER2-negative patients to determine their eligibility for HER2-directed therapy, particularly if their HER2 negativity was determined by a single test, especially if they had a single baseline HER2 IHC 1+ test.

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기사명 저자명 페이지 원문 목차
Intensity-modulated radiation therapy for uterine cervical cancer to reduce toxicity and enhance efficacy : an option or a must? : a narrative review Sea-Won Lee, Aeran Kim, Sung Jong Lee, Sung Hwan Kim, Jong Hoon Lee p. 1-17

Longitudinal changes in smoking behaviors and cancer-related mortality risk in middle-aged Korean women Thi Xuan Mai Tran, Soyeoun Kim, Seonju Kim, Boyoung Park p. 18-26

Trends and clinical characteristics of next-generation sequencing-based genetic panel tests : an analysis of Korean nationwide claims data Mi Jang, Hae Yong Pak, Ja Yoon Heo, Hyunsun Lim, Yoon-La Choi, Hyo Sup Shim, Eun Kyung Kim p. 27-36

(A) phase Ⅱ trial of nintedanib in patients with metastatic or recurrent head and neck squamous cell carcinoma : in-depth analysis of nintedanib arm from the KCSG HN 15-16 TRIUMPH trial Kyoo Hyun Kim, Sun Min Lim, Hee Kyung Ahn, Yun-Gyoo Lee, Keun-Wook Lee, Myung-Ju Ahn, Bhumsuk Keam, Hye Ryun Kim, Hyun Woo Lee, Ho Jung An, Jin-Soo Kim p. 37-47

Lazertinib versus gefitinib as first-line treatment for EGFR-mutated locally advanced or metastatic NSCLC : LASER301 Korean subset Ki Hyeong Lee, Byoung Chul Cho, Myung-Ju Ahn, Yun-Gyoo Lee, Youngjoo Lee, Jong-Seok Lee, Joo-Hang Kim, Young Joo Min, Gyeong-Won Lee, Sung Sook Lee ... [et al.] p. 48-60

First-line alectinib vs. brigatinib in advanced non–small cell lung cancer with ALK rearrangement : real-world data Youngkyung Jeon, Sehhoon Park, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn p. 61-69

Tumor microenvironment modulation by neoadjuvant erlotinib therapy and its clinical impact on operable EGFR-mutant non-small cell lung cancer Beung-Chul Ahn, Charny Park, Moon Soo Kim, Jong Mog Lee, Jin Ho Choi, Hyae Young Kim, Geon Kook Lee, Namhee Yu, Youngjoo Lee, Ji-Youn Han p. 70-80

Clinical validation of the unparalleled sensitivity of the novel allele-discriminating priming system technology-based EGFR mutation assay in patients with operable non-small cell lung cancer Il-Hyun Park, Dae-Soon Son, Yoon-La Choi, Ji-Hyeon Choi, Ji-Eun Park, Yeong Jeong Jeon, Minseob Cho, Hong Kwan Kim, Yong Soo Choi, Young Mog Shim ... [et al.] p. 81-91

Strategies to improve smoking cessation for participants in lung cancer screening program : analysis of factors associated with smoking cessation in Korean Lung Cancer Screening Project (K-LUCAS) Yeol Kim, Jaeho Lee, Eunju Lee, Juntae Lim, Yonghyun Kim, Choon-Taek Lee, Seung Hun Jang, Yu-Jin Paek, Won-Chul Lee, Chan Wha Lee ... [et al.] p. 92-103

Clinical impact of genomic and pathway alterations in stage Ⅰ EGFR-mutant lung adenocarcinoma Jae Seok Lee, Eun Kyung Kim, Kyung A Kim, Hyo Sup Shim p. 104-114

Aggressive local ablative radiotherapy mitigates progression risk in oligometastatic lung adenocarcinoma Gowoon Yang, Kyung Hwan Kim, Chang Geol Lee, Min Hee Hong, Hye Ryun Kim, Yeona Cho, Hong In Yoon p. 115-124

Impact of social support during diagnosis and treatment on disease progression in young patients with breast cancer : a prospective cohort study Danbee Kang, Seri Park, Hyo Jung Kim, Seok Won Kim, Jeong Eon Lee, Jonghan Yu, Se Kyung Lee, Ji-Yeon Kim, Seok Jin Nam, Juhee Cho, Yeon Hee Park p. 125-133

Toremifene, an alternative adjuvant endocrine therapy, is better than tamoxifen in breast cancer patients with CYP2D6*10 mutant genotypes Xin Li, Zehao Li, Lin Li, Tong Liu, Cheng Qian, Yanlv Ren, Zhigao Li, Kejin Chen, Dongchen Ji, Ming Zhang, Jinsong Wang p. 134-142

Short-term impact of hormone replacement therapy on risk of breast cancer in BRCA mutation carriers : a nationwide study in South Korea Hye Yeon Kim, Jisoo Park, Seok Joo Moon, Sohyeon Jeong, Jin Hwa Hong, Jae Kwan Lee, Geum Joon Cho, Hyun-Woong Cho p. 143-148

Next-generation sequencing in breast cancer patients : real-world data for precision medicine Hyunwoo Lee, Yoon Ah Cho, Deok Geun Kim, Eun Yoon Cho p. 149-161

Tumor microenvironment can predict chemotherapy response of patients with triple-negative breast cancer receiving neoadjuvant chemotherapy Dongjin Kim, Yeuni Yu, Ki Sun Jung, Yun Hak Kim, Jae-Joon Kim p. 162-177

Changes in invasive breast carcinomas after neoadjuvant chemotherapy can influence adjuvant therapeutic decisions Bárbara Jaime dos Santos, Débora Balabram, Virginia Mara Reis Gomes, Carolina Costa Café de Castro, Paulo Henrique Costa Diniz, Marcelo Araújo Buzelin, Cristiana Buzelin Nunes p. 178-190

Functional annotation and gene set analysis of gastric cancer risk loci in a Korean population Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim p. 191-198

GASTric Cancer HER2 Re-Assessment Study 2 (GASTHER2) : HER2 re-assessment for initially HER2-negative advanced gastric cancer patients after progression on first-line treatment Jaewon Hyung, Hyung-Don Kim, Min-Hee Ryu, Young Soo Park, Meesun Moon, Yoon-Koo Kang p. 199-207

First-in-human phase 1 study of a B cell- and monocyte-based immunotherapeutic vaccine against HER2-positive advanced gastric cancer Minkyu Jung, Jii Bum Lee, Hyo Song Kim, Woo Sun Kwon, Hyun Ok Kim, Sinyoung Kim, Myunghwan Park, Wuhyun Kim, Ki-Young Choi, Taegwon Oh, Chang-Yuil Kang, Hyun Cheol Chung, Sun Young Rha p. 208-218

Genomic and transcriptomic characterization of gastric cancer with bone metastasis Sujin Oh, Soo Kyung Nam, Keun-Wook Lee, Hye Seung Lee, Yujun Park, Yoonjin Kwak, Kyu Sang Lee, Ji-Won Kim, Jin Won Kim, Minsu Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim p. 219-237

Association between metabolically healthy status and risk of gastrointestinal cancer Haozhe Cui, Fei Tian, Yongliang Chen, Xiangming Ma p. 238-246

Risk stratification of pancreatic ductal adenocarcinoma patients undergoing curative-intent surgery after neoadjuvant therapy Hyun Kyung Yang, Mi-Suk Park, Kyunghwa Han, Geonsik Eom, Yong Eun Chung, Jin-Young Choi, Seungmin Bang, Chang Moo Kang, Jinsil Seong, Myeong-Jin Kim p. 247-258

Gemcitabine inhibits the progression of pancreatic cancer by restraining the WTAP/MYC chain in an m6A-dependent manner Pei Cao, Weigang Zhang, Junyi Qiu, Zuxiong Tang, Xiaofeng Xue, Tingting Feng p. 259-271

Risk factors for distant metastasis in extrahepatic bile duct cancer after curative resection (KROG 1814) Younghee Park, Tae Hyun Kim, Kyubo Kim, Jeong Il Yu, Wonguen Jung, Jinsil Seong, Woo Chul Kim, Jin Hwa Choi, Ah Ram Chang, Bae Kwon Jeong ... [et al.] p. 272-279

Clear cell adenocarcinoma of urethra : clinical and pathologic implications and characterization of molecular aberrations Boram Song, Seok Hyun Lee, Jeong Hwan Park, Kyung Chul Moon p. 280-293

Ten-year trends of hematopoietic stem cell transplantation in Korean pediatric cancer from the National Health Insurance claims data Hyery Kim, Hwa Jung Kim, Youngjun Jo, Su Hyun Yoon, Young Kwon Koh, Sunghan Kang, Kyung-Nam Koh, Ho Joon Im p. 294-304

Incidence and features of lymphoid proliferation and lymphomas after solid organ or hematopoietic stem cell transplantation in a national database cohort Seung Min Hahn, Myeongjee Lee, JongHoon Hyun, Sungmin Lim, Ji-Man Kang, Jong Gyun Ahn, Dong Jin Joo, Inkyung Jung, Kyong Ihn p. 305-313

Circulating tumor DNA reflects histologic and clinical characteristics of various lymphoma subtypes Jin Ju Kim, Hye Min Kim, Hongkyung Kim, Soo-Jeong Kim, Seung-Tae Lee, Jong Rak Choi, Saeam Shin, Doh Yu Hwang p. 314-323

Impact of T-cell engagers on COVID-19-related mortality in B-cell lymphoma patients receiving B-cell depleting therapy Chan Mi Lee, Pyoeng Gyun Choe, Chang Kyung Kang, Hyeon Jae Jo, Nam Joong Kim, Sung-Soo Yoon, Tae Min Kim, Wan Beom Park, Myoung-don Oh p. 324-333

Clinical features of Li-Fraumeni syndrome in Korea Ran Song, Sun-Young Kong, Wonyoung Choi, Eun-Gyeong Lee, Jaeyeon Woo, Jai Hong Han, Seeyoun Lee, Han-Sung Kang, So-Youn Jung p. 334-341

참고문헌 (24건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Gastric Cancer. 2019 May;22(3):518-525 미소장
2 Cancer Sci. 2016 Jul;107(7):1039-46 미소장
3 Eur J Cancer. 2018 Dec;105:41-49 미소장
4 Int J Cancer. 2017 Jan 1;140(1):188-196 미소장
5 Nature. 2014 Sep 11;513(7517):202-9 미소장
6 Nat Rev Clin Oncol. 2021 Aug;18(8):473-487 미소장
7 J Clin Oncol. 2021 May 1;39(13):1468-1478 미소장
8 J Gastroenterol. 2018 Nov;53(11):1186-1195 미소장
9 Lancet Oncol. 2014 Oct;15(11):1224-35 미소장
10 Lancet. 2020 Aug 29;396(10251):635-648 미소장
11 Gastric Cancer. 2016 Apr;19(2):553-560 미소장
12 Lancet. 2010 Aug 28;376(9742):687-97 미소장
13 J Clin Oncol. 2017 Feb;35(4):446-464 미소장
14 Lancet Oncol. 2017 May;18(5):640-653 미소장
15 Clin Cancer Res. 2016 Oct 15;22(20):5097-5108 미소장
16 CA Cancer J Clin. 2018 Jan;68(1):7-30 미소장
17 Ann Oncol. 2021 May;32(5):609-619 미소장
18 Gastric Cancer. 2019 May;22(3):527-535 미소장
19 Gastric Cancer. 2019 Jul;22(4):803-816 미소장
20 Int J Cancer. 2016 Dec 15;139(12):2859-2864 미소장
21 Eur J Cancer. 2016 Jan;53:42-50 미소장
22 Gastric Cancer. 2015 Jul;18(3):476-84 미소장
23 N Engl J Med. 2020 Jun 18;382(25):2419-2430 미소장
24 Gastric Cancer. 2022 Jul;25(4):794-803 미소장

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