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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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초록보기

Purpose: Numerous studies have supported the role of the immune dysfunction in the pathogenesis of autism spectrum disorder (ASD); however, to our knowledge, no study has been conducted on plasma cytokine levels in children with ASD in South Korea. In this study, we aimed to analyze the immunological characteristics of Korean children with ASD through plasma cytokine analysis.

Materials and Methods: Blood samples were collected from 94 ASD children (mean age 7.1; 81 males and 13 females) and 48 typically developing children (TDC) (mean age 7.3; 30 males and 18 females). Plasma was isolated from 1 mL of blood by clarifying with centrifugation at 8000 rpm at 4°C for 10 min. Cytokines in plasma were measured with LEGENDplex HU Th cytokine panel (BioLegend, 741028) and LEGENDplex HU cytokine panel 2 (BioLegend, 740102).

Results: Among 25 cytokines, innate immune cytokine [interleukin (IL)-33] was significantly decreased in ASD children compared with TDC. In acute phase proteins, tumor necrosis factor α (TNF-α) was significantly increased, while IL-6, another inflammation marker, was decreased in ASD children compared with TDC. The cytokines from T cell subsets, including interferon (IFN)-γ, IL-5, IL-13, and IL-17f, were significantly decreased in ASD children compared to TDC. IL-10, a major anti-inflammatory cytokine, and IL-9, which modulates immune cell growth and proliferation, were also significantly decreased in ASD children compared to TDC.

Conclusion: We confirmed that Korean children with ASD showed altered immune function and unique cytokine expression patterns distinct from TDC.

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기사명 저자명 페이지 원문 목차
Beneficial effects of low-grade mitochondrial stress on metabolic diseases and aging Se Hee Min, Gil Myoung Kang, Jae Woo Park, Min-Seon Kim p. 55-69

Alterations in plasma cytokine levels in Korean children with autism spectrum disorder Songjoo Shim, Sungji Ha, Juli Choi, Ho-Keun Kwon, Keun-Ah Cheon p. 70-77

Aetiology and prognosis of encephalitis in Korean children : a retrospective single-centre study, 2005–2020 Ahra Kim, Minyoung Kim, Jee Yeon Baek, Ji Young Lee, Se Hee Kim, Ji-Man Kang, Jong Gyun Ahn, Hoon-Chul Kang p. 78-88, [1-5]

Retention rates and successful treatment with antiseizure medications in newly-diagnosed epilepsy patients Sungeun Hwang, Hyungmi An, Dong Woo Shin, Hyang Woon Lee p. 89-97, [1-2]

Exploring the safety and efficacy of organic light-emitting diode in skin rejuvenation and wound healing Young In Lee, Sang Gyu Lee, Seoyoon Ham, Inhee Jung, Jangmi Suk, Ju Hee Lee p. 98-107, [1-4]

Reaching new heights : a comprehensive study of hand transplantations in Korea after institutionalization of hand transplantation law Yo Han Kim, Yun Rak Choi, Dong Jin Joo, Woo Yeol Baek, Young Chul Suh, Won Taek Oh, Jae Yong Cho, Sang Chul Lee, Sang Kyum Kim, Hyang Joo Ryu, Kyung Ock Jeon, Won Jai Lee, Jong Won Hong p. 108-119

Evaluation of the regulatory required post-authorization safety study for propacetamol : nested case-control and case-time-control studies Sungho Bea, Dongwon Yoon, Han Eol Jeong, Juhong Jung, Seung-Mok Park, Juhee Jeon, Young-Min Ye, Jae-Hyun Lee, Ju-Young Shin p. 120-128, [1-8]

참고문헌 (40건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders 미소장
2 Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank 미소장
3 Plasma levels of alarmin IL-33 are unchanged in autism spectrum disorder: A preliminary study 미소장
4 Elevated immune response in the brain of autistic patients 미소장
5 Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders 미소장
6 Inflammatory Cytokines: Potential Biomarkers of Immunologic Dysfunction in Autism Spectrum Disorders 미소장
7 Innate Immunity Associated with Inflammatory Responses and Cytokine Production against Common Dietary Proteins in Patients with Autism Spectrum Disorder 미소장
8 Astrocyte-targeted expression of IL-6 protects the CNSagainst a focal brain injury 미소장
9 Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder 미소장
10 The combined role of serotonin and interleukin-6 as biomarker for autism 미소장
11 Immune Endophenotypes in Children With Autism Spectrum Disorder 미소장
12 Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study 미소장
13 Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome 미소장
14 Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6 미소장
15 Prevalence of Autism Spectrum Disorders in a Total Population Sample 미소장
16 Plasma Cytokine Levels in a Population-Based Study: Relation to Age and Ethnicity 미소장
17 Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients 미소장
18 Multiple inflammasome complexes are activated in autistic spectrum disorders 미소장
19 The social responsiveness scale in relation to DSM IV and DSM5 ASD in Korean children 미소장
20 Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms 미소장
21 Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders 미소장
22 From the Cover: Interplay Between IFN-γ and IL-6 Impacts the Inflammatory Response and Expression of Interferon-Regulated Genes in Environmental-Induced Autoimmunity 미소장
23 Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism 미소장
24 Trends in the use of antibiotics among Korean children 미소장
25 A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude 미소장
26 Anti-inflammatory cytokines in autism spectrum disorders: A systematic review and meta-analysis 미소장
27 Serum cytokine levels in children with spectrum autism disorder: Differences in pro- and anti-inflammatory balance 미소장
28 Prevalence and Economic Burden of Autism Spectrum Disorder in South Korea Using National Health Insurance Data from 2008 to 2015 미소장
29 Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder 미소장
30 Prednisolone as Adjunctive Treatment to Risperidone in Children With Regressive Type of Autism Spectrum Disorder: A Randomized, Placebo-Controlled Trial 미소장
31 Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey 미소장
32 Features of the cytokine profile in children with autism spectrum disorder 미소장
33 Tumor necrosis factor‐α expression aberration of M1/M2 macrophages in adult high‐functioning autism spectrum disorder 미소장
34 Autism Diagnostic Observation Schedule 미소장
35 Diagnostic and Statistical Manual of Mental Disorders 미소장
36 Maternal Allergic Asthma Induces Prenatal Neuroinflammation 미소장
37 Prenatal Maternal Antibiotics Treatment Alters the Gut Microbiota and Immune Function of Post-Weaned Prepubescent Offspring 미소장
38 Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD) 미소장
39 Preliminary Findings of Elevated Inflammatory Plasma Cytokines in Children with Autism Who Have Co-Morbid Gastrointestinal Symptoms 미소장
40 Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020 미소장

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