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5-Methylcytosine (m⁵C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m⁵C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m⁵C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m⁵C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m⁵C reader and is involved in NSUN2-mediated E2F1 regulation. m⁵C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD⁵4L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m⁵C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.

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기사명 저자명 페이지 원문 목차
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop Sheng Yang, JiaJun Xie, ZhiJie Pan, HongMei Guan, YueSheng Tu, YuanJian Ye, ShouBin Huang, ShiQiang Fu, KangXian Li, ZhiWei Huang, XiaoQi Li, ZhanJun Shi, Le Li, Yang Zhang p. 1-16

Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer Taegeun Bae, Steffanus Pranoto Hallis, Mi-Kyoung Kwak p. 1-14

IL-27-induced PD-L1[high]Sca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner Keun Young Min, Do-Kyun Kim, Min Geun Jo, Min Yeong Choi, Dajeong Lee, Jeong Won Park, Young-Jun Park, Yeonseok Chung, Young Mi Kim, Yeong-Min Park, Hyuk Soon Kim, Wahn Soo Choi p. 1-14

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity Jihoon G. Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon ... [et al.] p. 1-13

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen ... [et al.] p. 1-16

Advances in cancer DNA methylation analysis with methPLIER : use of non-negative matrix factorization and knowledge-based constraints to enhance biological interpretability Ken Takasawa, Ken Asada, Syuzo Kaneko, Kouya Shiraishi, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Nobuji Kouno, Kazuma Kobayashi, Masaaki Komatsu ... [et al.] p. 1-10

Advances in single-cell omics and multiomics for high-resolution molecular profiling Jongsu Lim, Chanho Park, Minjae Kim, Hyukhee Kim, Junil Kim, Dong-Sung Lee p. 1-12

SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity Ji An Kang, Yoon Jung Kim, Kyu Yun Jang, Hye Won Moon, Haeseung Lee, Seonjeong Lee, Hyun Kyu Song, Sang Woo Cho, Yoon Sun Yoo, Hye Gyeong Han ... [et al.] p. 1-18

(The) Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress Dae Jin Jeong, Jee-Hyun Um, Young Yeon Kim, Dong Jin Shin, Sangwoo Im, Kang-Min Lee, Yun-Hee Lee, Dae-sik Lim, Donghoon Kim, Jeanho Yun p. 1-12

Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome : a translational perspective Tram T.T. Nguyen, Yoon Tae Kim, Geunyeol Jeong, Mirim Jin p. 1-11

Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Joo Young Lee, Hye Suk Lee ... [et al.] p. 1-14

Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy Byeong-Yun Ahn, Yan Zhang, Shibo Wei, Yideul Jeong, Dong-Hyun Park, Sang-Jin Lee, Young-Eun Leem, Jong-Sun Kang p. 1-10

Cancer-derived exosomal Alu RNA promotes colorectal cancer progression Sara Magliacane Trotta, Antonio Adinolfi, Luca D'Orsi, Sonia Panico, Grazia Mercadante, Patrick Mehlen, Jayakrishna Ambati, Sandro De Falco, Valeria Tarallo p. 1-11

Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism Kyung Hee Jung, Sujin Lee, Han Sun Kim, Jin-Mo Kim, Yun Ji Lee, Min Seok Park, Myeong-Seong Seo, Misu Lee, Mijin Yun, Sunghyouk Park, Soon-Sun Hong p. 1-13

Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy Jialiang Lin, Longjie Wang, Yuhao Wu, Qian Xiang, Yongzhao Zhao, Xuanqi Zheng, Shuai Jiang, Zhuoran Sun, Dongwei Fan, Weishi Li p. 1-13

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번호 참고문헌 국회도서관 소장유무
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