본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

초록보기

Malaria is a global disease affecting a large portion of the world’s population. Although vaccines have recently become available, their efficacies are suboptimal. We generated virus-like particles (VLPs) that expressed either apical membrane antigen 1 (AMA1) or microneme-associated antigen (MIC) of Plasmodium berghei and compared their efficacy in BALB/c mice. We found that immune sera acquired from AMA1 VLP- or MIC VLP-immunized mice specifically interacted with the antigen of choice and the whole P. berghei lysate antigen, indicating that the antibodies were highly parasite-specific. Both VLP vaccines significantly enhanced germinal center B cell frequencies in the inguinal lymph nodes of mice compared with the control, but only the mice that received MIC VLPs showed significantly enhanced CD4+ T cell responses in the blood following P. berghei challenge infection. AMA1 and MIC VLPs significantly suppressed TNF-α and interleukin-10 production but had a negligible effect on interferon-γ. Both VLPs prevented excessive parasitemia buildup in immunized mice, although parasite burden reduction induced by MIC VLPs was slightly more effective than that induced by AMA1. Both VLPs were equally effective at preventing body weight loss. Our findings demonstrated that the MIC VLP was an effective inducer of protection against murine experimental malaria and should be the focus of further development.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Dipylidiasis cases in Japan : an update by literature survey  Yukifumi Nawa, Akinori Furusawa, Mio Tanaka, Masahide Yoshikawa p. 163-168

(The) anti-amoebic activity of Pinus densiflora leaf extract against the brain-eating amoeba Naegleria fowleri Hương Giang Lê, Woong Kim, Jung-Mi Kang, Tuấn Cường Võ, Won Gi Yoo, Hyeonsook Cheong, Byoung-Kuk Na p. 169-179

Presence and diversity of free-living amoebae and their potential application as water quality indicators  Areum Choi, Ji Won Seong, Jeong Hyun Kim, Jun Young Lee, Hyun Jae Cho, Shin Ae Kang, Mi Kyung Park, Mi Jin Jeong, Seo Yeong Choi, Yu Jin Jeong, Hak Sun Yu p. 180-192

Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane antigen 1 Min-Ju Kim, Ki Back Chu, Keon-Woong Yoon, Hae-Ji Kang, Dong-Hun Lee, Eun-Kyung Moon, Fu-Shi Quan p. 193-204

Prostaglandin synthase activity of sigma- and mu-class glutathione transferases in a parasitic trematode, Clonorchis sinensis Jiyoung Kim, Woon-Mok Sohn, Young-An Bae p. 205-216

Comparative analysis of essential oil efficacy against the Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)  Mohammad Saiful Islam, Md. Samiul Haque, Myung-Jo You p. 217-225

Molecular cloning, identification, transcriptional analysis, and silencing of enolase on the life cycle of Haemaphysalis longicornis (Acari, Ixodidae) tick  Md. Samiul Haque, Md. Khalesur Rahman, Mohammad Saiful Islam, Myung-Jo You p. 226-237

(A) case of disseminated strongyloidiasis diagnosed by worms in the urinary sediment  Young-Ha Lee p. 238-242

Organ-specific Toxocara canis larvae migration and host immune response in experimentally infected mice  Min Seok Kim, Yan Jin, Se Joon Woo p. 243-250

Species identification and pyrethroid resistance genotyping of recently resurgent Cimex lectularius and Cimex hemipterus in Korea  Susie Cho, Heung Chul Kim, Hoonsik Eom, Jae Rok Lee, Chung Hyun Ko, E-hyun Shin, Won Kyu Lee, Si Hyeock Lee, Ju Hyeon Kim p. 251-256

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차