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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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BACKGROUND/OBJECTIVES: Breast cancer is considered a serious health issue worldwide and is influenced by risk factors, including physical inactivity and unhealthy diet. Myokines secreted by muscles during physical activity play a crucial role in cancer development and the immune system. Genistein (Gen), an isoflavone primarily in legumes, induces anti-cancer activity by regulating cancer stem cells (CSCs). Therefore, this study investigated the potential anti-cancer effect of a combination of myokine and Gen on the human breast cancer MCF-7 cells.

MATERIALS/METHODS: MCF-7, a human breast cancer cell line, was used for in vitro study. The cell viability of MCF-7 cells was evaluated in response to treatment with myokines, irisin (Iri), oncostatin M (OSM), and Gen using the MTT assay. Clonogenic and sphere formation assays were used to evaluate the self-renewal capacity of breast CSCs. The mRNA expression levels of stem cell markers were analyzed in MCF-7 breast cancer cells.

RESULTS: Administering Iri or OSM with Gen significantly inhibited the self-renewal capacity of MCF-7 cells. In addition, mRNA expression of breast CSC markers SOX2 and OCT4, which are characteristic of CSCs, was suppressed by both myokine and Gen. However, combining Iri or OSM with Gen was the most effective treatment.

CONCLUSION: These results suggested that combining Iri or OSM with Gen has an additive effect on breast CSCs by regulating self-renewal capacity and expression of CSCs markers. Therefore, the combination of myokines and Gen may have the therapeutic potential for treating breast cancer and improving the quality of life of cancer patients.

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기사명 저자명 페이지 원문 목차
Anti-osteoporotic effects of Boswellia serrata gum resin extract in vitro and in vivo Hyun Sook Lee, Jae In Jung, In-Kee Hong, YoungSun Jang, Hye-Bin Kim, Eun Ji Kim p. 309-324

Kaempferol ameliorates metabolic syndrome by inhibiting inflammation and oxidative stress in high-fat diet-induced obese mice Su-Kyung Shin, Eun-Young Kwon p. 325-344

Hypoglycemic and hypolipidemic effects of unsaponifiable matter from okra seed in diabetic rats Dongyeon Seo, Naeun Kim, Ahyeong Jeon, Jihyun Kwon, In-hwan Baek, Eui-Cheol Shin, Junsoo Lee, Younghwa Kim p. 345-356

Liquid collagen from freshwater fish skin ameliorates hydration, roughness and elasticity in photo-aged skin : a randomized, controlled, clinical study Joong Su Lee, Yeo Cho Yoon, Ju Myung Kim, Yun-Ho Kim, Young-Hee Kang, Yong Chul Shin p. 357-371

Development of a frailty prevention program including nutrition and exercise interventions for older adults in senior daycare centers in South Korea using a mixed methods research design Jiwon Sim, Jongguk Lim, Eunji Ko, Eunjin Jang, Minjeong Jeong, Sohyun Park p. 372-386

Relationships among tooth loss, prefrailty, and dietary patterns in community-dwelling older Japanese females : a cross-sectional study Tatsumi Hayashi, Rumi Sato, Kazuo Tamura p. 387-399

Malnutrition and its associated factors among community-dwelling older men living alone Gahye Kim, Minhwa Hwang, Seonghyeon Lee, Yeon-Hwan Park p. 400-411

Iodine intake from brown seaweed and the related nutritional risk assessment in Koreans Sung Ok Kwon, Kwang-Il Kwon, Mi-Young Lee, Hye Young Lee, Cho-il Kim p. 412-424

(A) study on the relationship between purchases of meal kits and home meal replacements Jong-Youn Rha, Haerang Lee, Sohyun Kim, Youngwon Nam p. 425-435

(A) combination of myokines and genistein suppresses cancer stemness in MCF-7 human breast cancer cells Hyeji Kwon, Yuri Kim, Jung Hyun Kim p. 436-445

참고문헌 (28건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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