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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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국회도서관 홈으로 정보검색 소장정보 검색
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Purpose: Claudins are a type of tight junction proteins in human endothelia and epithelia. Ozone brings about oxidative stress and lung inflammation in humans and experimental models. However, the impact of ozone on claudins in subjects with asthma remains poorly understood. The aim of this study was to find variations in the tight junction proteins claudin-4 and claudin-5 in subjects with asthma in relation to ambient ozone concentration.

Methods: We previously recruited 50 patients with stable/exacerbated asthmatics and 25 controls. Furthermore, to examine the influence of ozone concentration, we reanalyzed 18 patients with stable or exacerbated asthma and 3 controls. The plasma claudin-4 and claudin-5 levels in response to high concentrations of ozone were compared to stable/exacerbated asthma, and controls.

Results: The lung functions were significantly lower in subjects with asthma than those in controls. Blood eosinophil proportions were significantly higher in exacerbated asthmatics than in subjects with stable asthma. In high concentration period of ozone, plasma claudin-4 levels were significantly higher in subjects with exacerbated asthma (0.44±0.30 ng/mL, P=0.005) or stable asthma (0.38±0.31 ng/mL, P=0.009) compared to those in control subjects (0.16±0.1 ng/mL). Plasma claudin-5 levels were lower in subjects with stable asthma (2.97±1.38 ng/mL, P=0.011) than in control subjects (6.92±3.9 ng/mL), and higher in subjects with exacerbated asthma (7.49±4.23 ng/mL, P＜0.001) than those with stable asthma.

Conclusion: These results reveal that claudins be changed in patients with asthma following ozone exposure in subjects with asthma.

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대한천식알레르기학회 알레르기 면역요법 진료지침 = The Korean Academy of Asthma Allergy and Clinical Immunology guidelines for allergen immunotherapy 이화영, 강성윤, 김경훈, 김주희, 류광희, 민진영, 박경희, 박소영, 성명순, 이영수 [외] p. 102-124

대한천식알레르기학회 설하면역요법 진료지침 = The Korean Academy of Asthma Allergy and Clinical Immunology guidelines for sublingual immunotherapy 류광희, 지혜미, 이화영, 강성윤, 김경훈, 김주희, 박경희, 박소영, 성명순, 이영수 [외] p. 125-133

Impact of ozone on circulating tight junction protein claudin 4 and claudin 5 in patients with asthma Pureun-Haneul Lee, Min-Hyeok An, DaYeon Hwang, Byeong-Gon Kim, An-Soo Jang p. 134-139

메타콜린 기관지유발검사의 세 프로토콜 비교 = Comparison of 3 protocols in the methacholine bronchial provocation test 강성윤, 손지우, 이상민, 김세훈, 김태범, 이상표 p. 140-146

소아 갈치알레르기 = Cutlassfish allergy in children : usefulness of serum cod specific IgE and cross-reaction with cod : 대구 특이 IgE 검사 활용성 및 대구와의 교차반응 염상화, 프레브산 간툴가, 정경욱, 박경희, 박중원, 이수영 p. 147-154

Cerebral toxoplasmosis in a patient with Good’s syndrome : a case report and literature review Seoyoung Choi, Mi Jung Kwon, Eun Soo Kim, Heui Seung Lee, Younghee Jung, Joo-Hee Kim, Seung Hun Jang p. 155-159, [1]

기관지 내 결절과 무기폐로 발현한 호산구 육아종증 다발혈관염 1예 = Eosinophilic granulomatosis with polyangiitis presenting as an endobronchial nodule and ateletasis : a case report 류완호, 이원진, 조은정, 박혜경 p. 160-164

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