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Purpose: Alzheimer’s disease (AD) dementia may not be a single disease entity. Early-onset AD (EOAD) and late-onset AD (LOAD) have been united under the same eponym of AD until now, but disentangling the heterogeneity according to the age of sonset has been a major tenet in the field of AD research.

Materials and Methods: Ninety-nine patients with AD (EOAD, n=54; LOAD, n=45) and 66 cognitively normal controls completed both [18F]THK5351 and [18F]flutemetamol (FLUTE) positron emission tomography scans along with structural magnetic resonance imaging and detailed neuropsychological tests.

Results: EOAD patients had higher THK retention in the precuneus, parietal, and frontal lobe, while LOAD patients had higher THK retention in the medial temporal lobe. Intravoxel correlation analyses revealed that EOAD presented narrower territory of local FLUTE-THK correlation, while LOAD presented broader territory of correlation extending to overall parieto-occipito-temporal regions. EOAD patients had broader brain areas which showed significant negative correlations between cortical thickness and THK retention, whereas in LOAD, only limited brain areas showed significant correlation with THK retention. In EOAD, most of the cognitive test results were correlated with THK retention. However, a few cognitive test results were correlated with THK retention in LOAD.

Conclusion: LOAD seemed to show gradual increase in tau and amyloid, and those two pathologies have association to each other. On the other hand, in EOAD, tau and amyloid may develop more abruptly and independently. These findings suggest LOAD and EOAD may have different courses of pathomechanism.

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(The) association of smoking status with diabetic microvascular complications in Korean patients with type 2 diabetes Yongin Cho, Hye-Sun Park, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, Young Ju Suh, Suk Chon, Jeong-Taek Woo, Sei Hyun Baik, Kwan Woo Lee, So Hun Kim p. 427-433, [1-2]

Diverging relationships among amyloid, tau, and brain atrophy in early-onset and late-onset Alzheimer’s disease Han Kyu Na, Jeong-Hyeon Shin, Sung-Woo Kim, Seongho Seo, Woo-Ram Kim, Jae Myeong Kang, Sang-Yoon Lee, Jaelim Cho, Justin Byun, Nobuyuki Okamura, Joon-Kyung Seong, Young Noh p. 434-447, [1-8]

Minimally invasive open bilateral total thyroidectomy using unilateral neck incision in thyroid cancer : preliminary surgical and quality of life outcomes In A Lee, Minji Kim, Jin Kyong Kim, Cho Rok Lee, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung p. 448-455

One-year results of ear reconstruction with 3D printed implants Mijung Kim, Yun Jung Kim, Young Seok Kim, Tai Suk Roh, Eun-Ju Lee, Jin-Hyung Shim, Eun Hye Kang, Min Ji Kim, In Sik Yun p. 456-462

Evaluation of the current urgency-based lung allocation system in Korea with simulation of the eurotransplant lung allocation score Woo Sik Yu, Sun Mi Choi, Hye Ju Yeo, Dong Kyu Oh, Sung Yoon Lim, Young Tae Kim, Kyeongman Jeon, Jin Gu Lee p. 463-471

Cumulative effects of concurrent inspiratory muscle training and postural correction bands on older individuals community dwellers : a randomized study Tae Sung Park, Sang Hun Kim, Myung-Jun Shin p. 472-479

Analysis of prescription trends for narcotic appetite suppressants : utilizing the narcotics information management system Kyung Sun Oh, Euna Han p. 480-487, [1]

Recurrent acute limb ischemia and successful treatment with endovascular thrombectomy Bruce A. Rheaume, Muhammad Y. Adeel, Khagendra Dahal, Juyong Lee p. 488-491

참고문헌 (38건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe? 미소장
2 Functional connectivity changes differ in early and late-onset alzheimer's disease 미소장
3 The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease 미소장
4 Differences between early and late onset Alzheimer's disease. 미소장
5 Emerging β-Amyloid Pathology and Accelerated Cortical Atrophy 미소장
6 Individual subject classification for Alzheimer's disease based on incremental learning using a spatial frequency representation of cortical thickness data 미소장
7 Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis 미소장
8 Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer’s Disease 미소장
9 Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease 미소장
10 Anatomical heterogeneity of Alzheimer disease 미소장
11 Differences between Early and Late-Onset Alzheimer’s Disease in Neuropsychological Tests 미소장
12 Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden 미소장
13 Early-onset dementias: diagnostic and etiological considerations 미소장
14 Early-Onset Alzheimer’s Disease Is Associated With Greater Pathologic Burden 미소장
15 Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study 미소장
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37 Imaging of Reactive Astrogliosis by Positron Emission Tomography 미소장
38 Lecanemab in Early Alzheimer’s Disease 미소장

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