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The tumor microenvironment (TME) is formed by several immune cells. Notably, tumor-associated macrophages (TAMs) are existed in the TME that induce angiogenesis, metastasis, and proliferation of cancer cells. Recently, a point-mutated variant of IL-32θ was discovered in breast cancer tissues, which suppressed migration and proliferation through intracellular pathways. Although the relationship between cancer and IL-32 has been previously studied, the effects of IL-32θ on TAMs remain elusive. Recombinant human IL-32θ (rhIL-32θ) was generated using an Escherichia coli expression system. To induce M0 macrophage polarization, THP-1 cells were stimulated with PMA. After PMA treatment, the cells were cultured with IL-4 and IL-13, or rhIL-32θ. The mRNA level of M1 macrophage markers (IL-1β, TNFα, inducible nitric oxide synthase) were increased by rhIL-32θ in M0 macrophages. On the other hand, the M2 macrophage markers (CCL17, CCL22, TGFβ, CD206) were decreased by rhIL-32θ in M2 macrophages. rhIL-32θ induced nuclear translocation of the NF-κB via regulation of the MAPK (p38) pathway. In conclusion, point-mutated rhIL-32θ induced the polarization to M1-like macrophages through the MAPK (p38) and NF-κB (p65/p50) pathways.

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Oxidized LDL accelerates cartilage destruction and inflammatory chondrocyte death in osteoarthritis by disrupting the TFEB-regulated autophagy-lysosome pathway Jeong Su Lee, Yun Hwan Kim, JooYeon Jhun, Hyun Sik Na, In Gyu Um, Jeong Won Choi, Jin Seok Woo, Seung Hyo Kim, Asode Ananthram Shetty, Seok Jung Kim, Mi-La Cho p. 1-18

Influenza virus-derived CD8 T cell epitopes : implications for the development of universal influenza vaccines Sang-Hyun Kim, Erica Españo, Bill Thaddeus Padasas, Ju-Ho Son, Jihee Oh, Richard J. Webby, Young-Ran Lee, Chan-Su Park, Jeong-Ki Kim p. 1-15

(The) impact of pulmonary disorders on neurological health (lung-brain axis) Hongryeol Park, Chan Hee Lee p. 1-21

IL-1 receptor dynamics in immune cells : orchestrating immune precision and balance Dong Hyun Kim, Won-Woo Lee p. 1-16

Neutrophil migration is mediated by VLA-6 in the inflamed adipose tissue Hyunseo Lim, Young Ho Choe, Jaeho Lee, Gi Eun Kim, Jin Won Hyun, Young-Min Hyun p. 1-14

Exploring the potential of glycolytic modulation in myeloid-derived suppressor cells for immunotherapy and disease management Jisu Kim, Jee Yeon Choi, Hyeyoung Min, Kwang Woo Hwang p. 1-19

Recombinant human IL-32θ induces polarization into M1-like macrophage in human monocytic cells Hyo-Min Park, Jae-Young Park, Na-Yeon Kim, Hyemoon Kim, Hong-Gyum Kim, Dong-Ju Son, Jin Tae Hong, Do-Young Yoon p. 1-14

참고문헌 (44건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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