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결과 내 검색 동의어 포함

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초록보기

Objective: Disruptor of telomeric silencing 1-like (DOT1L) is the only known histone H3K79 methyltransferase essential for the development of the embryonic cardiovascular system, including the heart, blood vessels, and lymphatic vessels, through transcriptional regulation. Our previous study demonstrated that Dot1l deletion results in aberrant lymphatic development and function. However, its precise function in the postnatal cardiovascular system remains unknown.

Methods: Using conditional and inducible Dot1l knockout (KO) mice, along with a reporter strain carrying the Geo gene at the Dot1l locus, DOT1L expression and its function in the vascular system during postnatal life were investigated. To assess vessel morphology and vascular permeability, we administered Latex or Evans blue dye to KO mice. In addition, in vitro tube formation and cell migration assays were performed using DOT1L-depleted human umbilical vein endothelial cells (HUVECs). Changes in the expression of vascular genes in HUVECs were measured by quantitative polymerase chain reaction.

Results: Our findings demonstrate that conditional Dot1l knockout in the Tg (Tie2-cre) strain results in abnormal blood vessel formation and lymphatic anomalies in the intestine. In a mouse model of Rosa26-creER-mediated inducible Dot1l knockout, we observed vascular phenotypes, including increased vascular permeability and brain hemorrhage, when DOT1L was deleted in adulthood. Additionally, DOT1L depletion in cultured HUVECs led to impaired cell migration and tube formation, likely due to altered gene transcription. These findings highlight the essential role of DOT1L in maintaining vascular integrity and function during embryonic development and postnatal life.

Conclusion: Our study revealed that DOT1L is required for the maintenance of adult vascular function through the regulation of gene expression.

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기사명 저자명 페이지 원문 목차
Skin proteomic screening and functional analysis of differential proteins associated with coat color in sheep (Ovis aries) Zhihong Yin, Shitong Hao, Yuanyuan Zhao, Jinglong Li, Yunli Cui, Yaming Ge, Quanhai Pang p. 1503-1516

Association of histamine-N-methyl transferase gene polymorphisms with carnosine content in red-brown Korean native chickens Jean Pierre Munyaneza, Minjun Kim, Eunjin Cho, Aera Jang, Hyo Jun Choo, Jun Heon Lee p. 1517-1525

Image analysis traits of multiple muscles and intermuscular/subcutaneous fat influence Japanese black beef carcass price and genetic parameters Yuta Tamagawa, Mikiya Takahashi, Koichi Hagiya, Keigo Kuchida p. 1526-1534

Genome-wide association research on the reproductive traits of qianhua mutton merino sheep Jiarong Li, Limin Sun, Jiazhi Sun, Huaizhi Jiang p. 1535-1547

Freezing Hu ram semen : influence of different penetrating cryoprotectants and egg yolk level on the post-thaw quality of sperm Liuming Zhang, Caiyu Jiang, Xuyang Wang, Tariq Sohail, Yuxuan Sun, Xiaomei Sun, Jian Wang, Yongjun Li p. 1548-1557

Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation Silong Zhang, Hanbing Zhang, Kexiong Liu, Xiaoling Xu, Yusheng Qin, Linli Xiao, Chunmei Zhou, Jianliang Wu, Yan Liu, Jiahua Bai p. 1558-1567

Repeatability of feed efficiency and its relationship with carcass traits in Hanwoo steers during their entire growing and fattening period Hyunjin Cho, Kyewon Kang, Hamin Kang, Seoyoung Jeon, Mingyung Lee, Eunkyu Park, Seokman Hong, Seongwon Seo p. 1568-1580

Expression and characterization of a novel microbial GH9 glucanase, IDSGLUC9-4, isolated from sheep rumen Yongzhen Zhu, Shuning Bai, Nuo Li, Jun-Hong Wang, Jia-Kun Wang, Qian Wang, Kaiying Wang, Tietao Zhang p. 1581-1594

Effects of fruit and vegetable waste addition on corn stalk silage quality Li Li Wang, Yan Fen Li, Li Zhuang Wu, Young Sang Yu, Xaysana Panyavong, Jong Geun Kim p. 1595-1602

Effects of dietary supplementation of vitamin A on the tibia quality of goslings Xia Xiao, Haiming Yang, Xiaoli Wan, Zhiyue Wang p. 1603-1613

Effects of dietary deoxynivalenol on growth performance and organ accumulation of growing pigs Ah Reum Son, Seung Youp Shin, Yoon Soo Song, Bokyung Hong, Beob Gyun Kim p. 1614-1621

Dietary apidaecin Api-PR19 addition enhances growth performance by regulating gut health and microbiota in broilers Chenxu Wang, Xinrui Wang, Rui Liu, Jiyang Min, Xiaojun Yang, Lixin Zhang p. 1622-1634

DOT1-like histone lysine methyltransferase is critical for adult vessel maintenance and functions HeeJi Lee, Dong Wook Han, Hyeonwoo La, Chanhyeok Park, Kiye Kang, Ohbeom Kwon, Sang Jun Uhm, Hyuk Song, Jeong Tae Do, Youngsok Choi, Kwonho Hong p. 1635-1643

Serological and epidemiological investigation of Mycobacterium avium subspecies paratuberculosis in bovines in Pakistan Aziz ur Rehman, Muhammad Tariq Javed, Ishtiaq Ahmed, Muhammad Adnan Saeed, Syed Ehtisham-ul-Haque, Muhammad Kamran Rafique, Arbab Sikandar, Amar Nasir, Latif Ahmad, Muhammad Kashif, Muhammad Abid Zeeshan p. 1644-1652

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번호 참고문헌 국회도서관 소장유무
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