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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our immune system. When infections or threats to the body’s defense mechanisms are detected, the innate immune system takes the lead. However, an excessive inflammatory response can lead to the production of high concentrations of cytotoxic molecules, resulting in tissue damage. Inflammasomes are significant contributors to innate immunity, and one of the most extensively studied inflammasome complexes is NOD-like receptor 3 (NLRP3). NLRP3 has a wide range of recognition mechanisms that streamline immune activation and eliminate pathogens. These cytosolic multiprotein complexes are composed of effector, adaptor, and sensor proteins, which are crucial for identifying intracellular bacterial breakdown products and initiating an innate immune cascade. To understand the diverse behavior of NLRP3 activation and its significance in the development of lifestyle-related diseases, one must delve into the study of the immune response and apoptosis mediated by the release of proinflammatory cytokines. In this review, we briefly explore the immune response in the context of lifestyle associated disorders such as obesity, hyperlipidemia, diabetes, chronic respiratory disease, oral disease, and cardiovascular disease.

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기사명 저자명 페이지 원문 목차
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions Gaopeng Xian, Rong Huang, Minhui Xu, Hengli Zhao, Xingbo Xu, Yangchao Chen, Hao Ren, Dingli Xu, Qingchun Zeng p. 1-14

PHGDH : a novel therapeutic target in cancer Chae Min Lee, Yeseong Hwang, Minki Kim, Ye-Chan Park, Hyeonhui Kim, Sungsoon Fang p. 1-10

PLD1 is a key player in cancer stemness and chemoresistance : therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways Seong Hun Lim, Hyesung Lee, Hyun Ji Lee, Kuglae Kim, Junjeong Choi, Jung Min Han, Do Sik Min p. 1-9

Patient-derived tumor organoids : a new avenue for preclinical research and precision medicine in oncology Lucie Thorel, Marion Perréard, Romane Florent, Jordane Divoux, Sophia Coffy, Audrey Vincent, Cédric Gaggioli, Géraldine Guasch, Xavier Gidrol, Louis-Bastien Weiswald, Laurent Poulain p. 1-21

YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis Wei Su, Yingying Guo, Qianqian Wang, Lu Ma, Qing Zhang, Yuhan Zhang, Yiding Geng, Tongzhu Jin, Jiayu Guo, Ruoxuan Yang ... [et al.] p. 1-12

FGFR3 drives Aβ-induced tau uptake Dong Kyu Kim, Kyujin Suh, Junho Park, Sang-Eun Lee, Jihui Han, Sunghoe Chang, Youngsoo Kim, Inhee Mook-Jung p. 1-12

Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia Seo Yeon Jin, Jung Min Ha, Hye Jin Kum, Ji Soo Ma, Hong Koo Ha, Sang Heon Song, Yong Ryoul Yang, Ho Lee, Yoon Soo Bae, Masahiro Yamamoto, Pann-Ghill Suh, Sun Sik Bae p. 1-11

MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis Dong-Joon Lee, Pyunggang Kim, Hyun-Yi Kim, Jinah Park, Seung-Jun Lee, Haein An, Jin Sun Heo, Min-Jung Lee, Hayato Ohshima, Seiya Mizuno, Satoru Takahashi, Han-Sung Jung, Seong-Jin Kim p. 1-14

Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegⅢγ Minglong Qiu, Leilei Chang, Guoqing Tang, Wenkai Ye, Yiming Xu, Nijiati Tulufu, Zhou Dan, Jin Qi, Lianfu Deng, Changwei Li p. 1-17

NLRP3 inflammasome : a key player in the pathogenesis of life-style disorders Rajath Ramachandran, Abdul Manan, Jei Kim, Sangdun Choi p. 1-13

(The) role of BCAA metabolism in metabolic health and disease Byeong Hun Choi, Seunghoon Hyun, Seung-Hoi Koo p. 1-8

Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development Hao Zeng, Xue Yang, Kai Liao, Xin Zuo, Lihong Liang, Dalian He, Rong Ju, Bowen Wang, Jin Yuan p. 1-12

Accelerated aging of skeletal muscle and the immune system in patients with chronic liver disease Thomas Nicholson, Amritpal Dhaliwal, Jonathan I. Quinlan, Sophie L. Allen, Felicity R. Williams, Jon Hazeldine, Kirsty C. McGee, Jack Sullivan, Leigh Breen, Ahmed M. Elsharkawy, Matthew J. Armstrong, Simon W. Jones, Carolyn A. Greig, Janet M. Lord p. 1-15

참고문헌 (130건) : 자료제공( 네이버학술정보 )

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