본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

초록보기

Background: Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.

Objective: This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.

Methods: We analyzed microarray data (GSE41662) to investigate the gene expression of SKP2 in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-stimulated keratinocytes by using real-time quantitative polymerase chain reaction and western blot (WB). Furthermore, we explored the potential pathogenic role and its underlying cellular mechanism of SKP2 in promoting keratinocytes hyperproliferation through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cell cycle detection, 5-ethynyl-2′-deoxyuridine staining and WB. Finally, we determined whether inhibition of SKP2 can effectively alleviate the keratinocytes hyperproliferation in vivo.

Results: We identified that SKP2 is aberrantly upregulated in the psoriatic lesion skin and cytokines-stimulated keratinocytes. Moreover, upregulated SKP2 augments cytokines-induced keratinocytes hyperproliferation. Mechanistically, enhanced SKP2 increased the S phase ratio through inhibiting Cyclin-Dependent Kinase Inhibitor p27 (P27 Kip1) expression. Correspondingly, suppression of SKP2 with SMIP004 can significantly ease the epidermis hyperplasia in vivo.

Conclusion: Our results suggest that elevated SKP2 can empower keratinocytes proliferation and psoriasis-like epidermis hyperplasia via downregulation of P27 Kip1. Therefore, targeting SKP2-P27 Kip1 axis might be a promising therapeutic strategy for the treatment of psoriasis in future.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Updates in dermatomyositis : newer treatment options and outcome measures from dermatologic perspectives Hee Joo Kim, Victoria P. Werth p. 257-265

(A) randomized, split-face, comparative study of a combined needle radiofrequency/intense pulsed light device in moderate-to-severe acne patients Ki Yeon Kim, Seon Young Song, You Jin Jung, Mihn Sook Jue, Ji Yeon Hong, Beom Joon Kim, Joo Yeon Ko p. 266-274

Skin hydration measurement : comparison between devices and clinical evaluations Ju Heon Park, YoungHwan Choi, Yeon Joo Jung, Taemin Lee, Heeyeon Kim, Youngjoo Cho, Jong Hee Lee p. 275-281

Upregulated SKP2 empowers epidermal proliferation through downregulation of P27 Kip1 Lipeng Tang, Bowen Zhang, Guanzhuo Li, Xinmin Qiu, Zixin Dai, Hongying Liu, Ying Zhu, Bing Feng, Zuqing Su, Wenhui Han ... [et al.] p. 282-291

Dickkopf-related protein 2 promotes hair growth by upregulating the Wnt/β-catenin signaling pathway in human dermal papilla cells Seon Bok Lee, Jae Won Lee, Hyemin Lee, Kyung-Ju Lee, Hye Won Hwang, Hyun-Tae Shin, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi p. 292-299

Plasma metabolomics indicates potential biomarkers and abnormal metabolic pathways in female melasma patients Xiaoli Zhang, Yi Chen, Hedan Yang, Hui Ding, Pingping Cai, Yiping Ge, Huiying Zheng, Xiaojie Sun, Yin Yang, Xinyu Li, Tong Lin p. 300-309

Exploring the interplay : obesity, lipid metabolism, and clinical manifestations in atopic dermatitis Howard Chu, Yeon Woo Jung, Su Min Kim, Byung Gi Bae, Jung Min Bae, Lark Kyun Kim, Kwang Hoon Lee, Chang Ook Park p. 310-317

Clinical differential diagnosis of poroma and poroma mimicker : retrospective, multi-center study in Korea Jung Eun Seol, Sang Woo Ahn, Seung Hee Jang, Seong Min Hong, So Young Jung, So Hee Park, Un Ha Lee, Hai Jin Park, Hyojin Kim p. 318-321

(The) family dermatology life quality index of spouses of patients with psoriasis : a cross-sectional study Min Wu, Yingyuan Yu, Dawei Huang, Kai Wang, Yangfeng Ding, Yi Zhang, Yuling Shi, Xiaoping Zhu p. 322-325

Similar seasonality in childhood-onset, pediatric, and adulthood-onset vitiligo : a common data model analysis of 16 real-world databases Yun-ji Lee, Yoonsung Lee, Man S. Kim, Bark-Lynn Lew, Soon-Hyo Kwon p. 326-328

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차