본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

초록보기

Transmembrane proteins (TMEMs) are frequently used as prognostic biomarkers for various cancer types, making them a significant area of interest in cancer research. The prognostic significance of transmembrane protein 14C (TMEM14C) and its association with tumor-infiltrating immune cells (TIICs) has not been explored in liver hepatocellular carcinoma (LIHC). This study aimed to assess the potential prognostic value of TMEM14C by conducting a comprehensive analysis of online databases on LIHC. We evaluated the potential of TMEM14C as a prognostic biomarker using online databases such as TIMER, GEPIA2, UALCAN, OSlihc, and LinkedOmics. We observed that the mRNA expression of TMEM14C was upregulated in LIHC than that in normal tissues. Upregulated TMEM14C expression was associated with worse prognosis based on the clinicopathological characteristics of patients with LIHC. Furthermore, TMEM14C expression was positively associated with TIICs. In the co-expression and functional enrichment analyses of TMEM14C, 7,401 genes were positively associated with TMEM14C, whereas 12,520 genes showed negative associations. The results of gene set enrichment analysis (GSEA)-Gene Ontology showed that TMEM14C-related co-expression genes were involved in protein localization to translational elongation, protein localization to the endoplasmic reticulum, and mitochondrial gene expression. Furthermore, GSEA-Kyoto Encyclopedia of Genes and Genomes analysis showed that these genes regulated ribosomes, oxidative phosphorylation, and spliceosomes. A survival map revealed that 28 and 24 genes that were positively associated with TMEM14C showed significant hazard ratios for overall survival and diseasefree survival, respectively. Our findings demonstrate that TMEM14C is a novel prognostic biomarker and a potential tumor immune therapeutic target in patients with LIHC.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
국내 체질인류학의 연구 분야와 그 변화에 대한 검토 = A review of the sub-disciplines and their changes in physical anthropology in Korea : 대한체질인류학회지와 해부·생물인류학에 출판된 원저논문을 중심으로 우은진, 김민서, 이대한, 서민우 p. 125-131
Estimation of adult stature based on patella morphology in a Korean population : postmortem computed tomography-based study Eunseo Park, Ji Won Hwang, Bo Yong Yu, Se-Min Oh, Kwang Rak Park p. 133-140
CT number 및 척추원반 높이를 이용한 퇴행성 척추원반 질환 진단의 유용성 = Diagnostic usefulness of degenerative disc disease using the CT number and disc height 박태수, 윤식 p. 141-150
신체특성에 따른 최대산소섭취량의 관련성 분석 = Analysis of the relationship between maximum oxygen uptake and physical characteristics 옥현태, 이수정, 오민광, 손현준 p. 151-160
흰쥐 삼차신경절 신경세포에서 P2X3와 vesicular glutamate transporters의 발현양식 및 말초 염증에 따른 변화 = Expression patterns of P2X3 and vesicular glutamate transporters in rat trigeminal ganglion neurons and their changes during peripheral inflammation 김윤숙, 홍재현, 조이슬, 배용철 p. 161-171
아동학대 사건에서 진단하지 못한 갈비뼈 골절에 대한 법의인류학적 고찰 = Forensic anthropological implication of undetected rib fractures in child abuse case 이지형, 박대균 p. 173-180
메디컬아트 분야 융복합 진로탐색 교육 프로그램 개발 사례 연구 = Case study on development of convergence career exploration educational program in the medical arts field 박사범, 황윤자 p. 181-188
TMEM14C is a novel biomarker for prognosis and diagnosis of liver hepatocellular carcinoma Hye-Ran Kim, Jongwan Kim, Hyun Jun Woo, Mi-Suk Park p. 189-199

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차